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GENE：HEY1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HEY1
FullNmae hes related family bHLH transcription factor with YRPW motif 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4880
EnsembleID ENSG00000164683
Uniprot Q9Y5J3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HEY1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HEY1 GO:0000122,GO:0000122,GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001227,GO:0001525,GO:0003161,GO:0003180,GO:0003184,GO:0003190,GO:0003203,GO:0003208,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0007219,GO:0007219,GO:0009952,GO:0035912,GO:0036304,GO:0045665,GO:0045746,GO:0045892,GO:0045944,GO:0046983,GO:0050767,GO:0060317,GO:0060347,GO:0060411,GO:0060412,GO:0060716,GO:0060842,GO:0061314,GO:0061629,GO:0070168,GO:0072359,GO:1990837,GO:2000678,GO:2000820,GO:2001212

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HEY1 hsa:23462 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
HEY1 hsa:23462 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
HEY1 hsa:23462 path:hsa05200 Pathways in cancer - Homo sapiens (human)
HEY1 hsa:23462 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR HEY1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 HEY1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 HEY1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 HEY1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 HEY1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HEY1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 HEY1 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HEY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DUX4 HEY1 24278031 trascriptional regulation,stimulation inferred by curator TFlink
JUN HEY1 15314183 trascriptional regulation,stimulation inferred by curator TFlink
MAML1 HEY1 18503747 trascriptional regulation,stimulation inferred by curator TFlink
MSX1 HEY1 18201699 trascriptional regulation,stimulation inferred by curator TFlink
NR2F2 HEY1 23345397 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 HEY1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000ED600 HEY1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00002152A8 HEY1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002233F4 HEY1 25416803 25998143 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
FBXW7 HEY1 25361965 interaction type N/A PTMCode2
HEY1 FBXW7 25361965 interaction type N/A PTMCode2
HEY1 GATA1 25361965 interaction type N/A PTMCode2
GATA1 HEY1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK HEY1 25348397 N/A physical interaction ComPPI
SNRPB HEY1 25348397 N/A physical interaction ComPPI
HSPA8 HEY1 25348397 N/A physical interaction ComPPI
RPL9 HEY1 25348397 N/A physical interaction ComPPI
RPS7 HEY1 25348397 N/A physical interaction ComPPI
VIM HEY1 25348397 N/A physical interaction ComPPI
SKIL HEY1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TUBB HEY1 25348397 N/A physical interaction ComPPI
SNRPD1 HEY1 25348397 N/A physical interaction ComPPI
VCP HEY1 25348397 N/A physical interaction ComPPI
RPL11 HEY1 25348397 N/A physical interaction ComPPI
DERL2 HEY1 25348397 N/A physical interaction ComPPI
ACTB HEY1 25348397 N/A physical interaction ComPPI
SKP1 HEY1 10213691 10385629 11283612 20581845 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FRG1 HEY1 25348397 N/A physical interaction ComPPI
HSP90AB1 HEY1 25348397 N/A physical interaction ComPPI
HEY2 HEY1 25348397 N/A physical interaction ComPPI
LAPTM5 HEY1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TLE1 HEY1 25348397 N/A physical interaction ComPPI
MYOD1 HEY1 11279181 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
FBXW7 HEY1 11585921 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 HEY1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
NONO HEY1 25348397 N/A physical interaction ComPPI
GATA1 HEY1 14525934 15314183 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FLNA HEY1 25348397 N/A physical interaction ComPPI
TTN HEY1 25348397 N/A physical interaction ComPPI
TUBA1B HEY1 25348397 N/A physical interaction ComPPI
APC HEY1 25348397 N/A physical interaction ComPPI
SMAD9 HEY1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YBX1 HEY1 25348397 N/A physical interaction ComPPI
FMNL1 HEY1 25348397 N/A physical interaction ComPPI
HSPA5 HEY1 25348397 N/A physical interaction ComPPI
HSPA1A HEY1 25348397 N/A physical interaction ComPPI
HSPA1B HEY1 25348397 N/A physical interaction ComPPI
FEN1 HEY1 25348397 N/A physical interaction ComPPI
CDC6 HEY1 25348397 N/A physical interaction ComPPI
HEY1 ELAVL1 25348397 N/A physical interaction ComPPI
HEY1 ARNT 10692439 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
HEY1 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HEY1 SYVN1 25348397 N/A physical interaction ComPPI
HEY1 SEL1L 25348397 N/A physical interaction ComPPI
HEY1 HES1 25348397 N/A physical interaction ComPPI
HEY1 MYCBP2 25348397 N/A physical interaction ComPPI
HEY1 FBXO45 25348397 26068074 27898060 N/A physical interaction ComPPI,OmniPath
HEY1 DPF3 25348397 N/A physical interaction ComPPI
HEY1 TP53 25348397 N/A physical interaction ComPPI
HEY1 STK38 25348397 N/A physical interaction ComPPI
HEY1 STK38L 25348397 N/A physical interaction ComPPI
HEY1 MDM2 25348397 N/A physical interaction ComPPI
HEY1 CSNK2B 25348397 N/A physical interaction ComPPI
HEY1 MARK3 25348397 N/A physical interaction ComPPI
HEY1 TUBB4B 25348397 N/A physical interaction ComPPI
HEY1 TUBA1A 25348397 N/A physical interaction ComPPI
HEY1 TUBB2A 25348397 N/A physical interaction ComPPI
HEY1 MC1R 25348397 N/A physical interaction ComPPI
HEY1 TUBB3 25348397 N/A physical interaction ComPPI
HEY1 TUBA4A 25348397 N/A physical interaction ComPPI
HEY1 TUBB4A 25348397 N/A physical interaction ComPPI
HEY1 CCT5 25348397 N/A physical interaction ComPPI
HEY1 CCT6A 25348397 N/A physical interaction ComPPI
HEY1 CCT8 25348397 N/A physical interaction ComPPI
HEY1 CCDC78 25348397 N/A physical interaction ComPPI
HEY1 CCDC88A 25348397 N/A physical interaction ComPPI
HEY1 CCDC124 25348397 N/A physical interaction ComPPI
HEY1 TMA7 25348397 N/A physical interaction ComPPI
HEY1 SYNE1 25348397 N/A physical interaction ComPPI
HEY1 SYNE2 25348397 N/A physical interaction ComPPI
HEY1 TNKS 25348397 N/A physical interaction ComPPI
HEY1 TNKS1BP1 25348397 N/A physical interaction ComPPI
HEY1 AKAP9 25348397 N/A physical interaction ComPPI
HEY1 CEP192 25348397 N/A physical interaction ComPPI
HEY1 PLEC 25348397 N/A physical interaction ComPPI
HEY1 EWSR1 25348397 N/A physical interaction ComPPI
HEY1 CSNK2A1 25348397 N/A physical interaction ComPPI
HEY1 MIS18BP1 25348397 N/A physical interaction ComPPI
HEY1 PTPN13 25348397 N/A physical interaction ComPPI
HEY1 RAB1A 25348397 N/A physical interaction ComPPI
HEY1 DCTN1 25348397 N/A physical interaction ComPPI
HEY1 BIRC6 25348397 N/A physical interaction ComPPI
HEY1 PCLAF 25348397 N/A physical interaction ComPPI
HEY1 RPL8 25348397 N/A physical interaction ComPPI
HEY1 RPS10 25348397 N/A physical interaction ComPPI
HEY1 RPS19 25348397 N/A physical interaction ComPPI
HEY1 RPL15 25348397 N/A physical interaction ComPPI
HEY1 RPS16 25348397 N/A physical interaction ComPPI
HEY1 RPS18 25348397 N/A physical interaction ComPPI
HEY1 RPL12 25348397 N/A physical interaction ComPPI
HEY1 RPS3 25348397 N/A physical interaction ComPPI
HEY1 RPS29 25348397 N/A physical interaction ComPPI
HEY1 RPS20 25348397 N/A physical interaction ComPPI
HEY1 HNRNPA1 25348397 N/A physical interaction ComPPI
HEY1 SNRPD3 25348397 N/A physical interaction ComPPI
HEY1 RPL22L1 25348397 N/A physical interaction ComPPI
HEY1 RPS17 25348397 N/A physical interaction ComPPI
HEY1 RPS5 25348397 N/A physical interaction ComPPI
HEY1 FAU 25348397 N/A physical interaction ComPPI
HEY1 FAU 25348397 N/A physical interaction ComPPI
HEY1 HNRNPH1 25348397 N/A physical interaction ComPPI
HEY1 RPS15A 25348397 N/A physical interaction ComPPI
HEY1 HNRNPLL 25348397 N/A physical interaction ComPPI
HEY1 HNRNPD 25348397 N/A physical interaction ComPPI
HEY1 HNRNPA2B1 25348397 N/A physical interaction ComPPI
HEY1 FBL 25348397 N/A physical interaction ComPPI
HEY1 DDX5 25348397 N/A physical interaction ComPPI
HEY1 NOLC1 25348397 N/A physical interaction ComPPI
HEY1 YLPM1 25348397 N/A physical interaction ComPPI
HEY1 EZR 25348397 N/A physical interaction ComPPI
HEY1 DDX46 25348397 N/A physical interaction ComPPI
HEY1 IQSEC1 25348397 N/A physical interaction ComPPI
HEY1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HEY1 PLEKHB2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HEY1 KRTAP6-2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HEY1 DAZAP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HEY1 YTHDF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HEY1 FOXH1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPS25 HEY1 25348397 N/A physical interaction ComPPI
RPL23 HEY1 25348397 N/A physical interaction ComPPI
RPS14 HEY1 25348397 N/A physical interaction ComPPI
TENT5D HEY1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNRNP27 HEY1 25348397 N/A physical interaction ComPPI
HEY1 HEY1 11279181 14525934 N/A experimental interaction detection HPRD
UBE2M HEY1 20832729 21816351 27898060 N/A N/A OmniPath
CUL3 HEY1 12676951 27898060 N/A N/A OmniPath
CDC34 HEY1 10213692 10385629 12553912 13678584 14747994 17574027 19945379 20194622 20542006 21098119 22328159 24316736 27898060 9285816 9346238 N/A N/A OmniPath
CCDC89 HEY1 14648848 27898060 N/A N/A OmniPath
HEY1 RBPJ 16682003 27898060 inhibition N/A OmniPath
NOTCH1 HEY1 15207708 27898060 stimulant N/A OmniPath

Visualization










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