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GENE：CHAC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CHAC1
FullNmae ChaC glutathione specific gamma-glutamylcyclotransferase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28680
EnsembleID ENSG00000128965
Uniprot Q9BUX1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CHAC1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHAC1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CHAC1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHAC1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHAC1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CHAC1 GO:0003839,GO:0003839,GO:0005112,GO:0005515,GO:0005737,GO:0005802,GO:0005829,GO:0005829,GO:0006750,GO:0006751,GO:0006986,GO:0007219,GO:0010955,GO:0022008,GO:0045746,GO:0061928,GO:0070059

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CHAC1 hsa:79094 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
CHAC1 hsa:79094 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CHAC1 RHOXF2 16189514 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CHAC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CHAC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CHAC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CHAC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CHAC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CHAC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CHAC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CHAC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 CHAC1 21737788 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 CHAC1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 CHAC1 20371350 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000015F70F CHAC1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA CHAC1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 CHAC1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B CHAC1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 CHAC1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041CB9C CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040EE1D CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001919B0 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007D64A CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DABC0 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002004E0 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000042935A CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000475586 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000044FD7 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F6E49 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E226A CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000028BB8 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000027F5F3 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000045ED38 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000519450 CHAC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 CHAC1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000184017 CHAC1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDE70 CHAC1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A CHAC1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RHOXF2 CHAC1 14525934 16189514 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct

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