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GENE：SHMT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SHMT1
FullNmae serine hydroxymethyltransferase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10850
EnsembleID ENSG00000176974
Uniprot P34896

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SHMT1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SHMT1 GO:0000900,GO:0000900,GO:0004372,GO:0004372,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006231,GO:0006544,GO:0006563,GO:0006565,GO:0006565,GO:0008270,GO:0009113,GO:0009113,GO:0017148,GO:0019264,GO:0030170,GO:0030170,GO:0035999,GO:0035999,GO:0035999,GO:0036094,GO:0042802,GO:0042803,GO:0042803,GO:0046653,GO:0046655,GO:0046655,GO:0048027,GO:0048027,GO:0051289,GO:0051289,GO:0070062,GO:0070905,GO:0070905,GO:1904482,GO:1990830

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SHMT1 hsa:6470 path:hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human)
SHMT1 hsa:6470 path:hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
SHMT1 hsa:6470 path:hsa00670 One carbon pool by folate - Homo sapiens (human)
SHMT1 hsa:6470 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SHMT1 hsa:6470 path:hsa01200 Carbon metabolism - Homo sapiens (human)
SHMT1 hsa:6470 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
SHMT1 hsa:6470 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)
SHMT1 hsa:6470 path:hsa01523 Antifolate resistance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 SHMT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
E2F4 SHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SHMT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC SHMT1 12138190 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 SHMT1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000031E12 SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003677B2 SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003758F0 SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001F5B39 SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C7B2B SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EED18 SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BE495 SHMT1 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000243FF1 SHMT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 SHMT1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F SHMT1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 SHMT1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 SHMT1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SHMT1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000585553 SHMT1 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004DA9DB SHMT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 SHMT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SHMT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC SHMT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE SHMT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D4175 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FBC84 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006372A SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B0E50 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005E1A16 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000355E82 SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041FA2C SHMT1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DDX6 SHMT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK9 SHMT1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STAT1 SHMT1 25348397 N/A physical interaction ComPPI
SMAD4 SHMT1 25348397 N/A physical interaction ComPPI
KEAP1 SHMT1 25348397 N/A physical interaction ComPPI
MAP1LC3B SHMT1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MDFI SHMT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
H4C1 SHMT1 25348397 N/A physical interaction ComPPI
ABRAXAS2 SHMT1 25348397 N/A physical interaction ComPPI
PIM1 SHMT1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
JUN SHMT1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
IFNAR1 SHMT1 25348397 N/A physical interaction ComPPI
ARFIP1 SHMT1 25348397 N/A physical interaction ComPPI
SNX2 SHMT1 25348397 N/A physical interaction ComPPI
SNX6 SHMT1 25348397 N/A physical interaction ComPPI
XPO5 SHMT1 25348397 N/A physical interaction ComPPI
GORASP2 SHMT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STXBP1 SHMT1 25348397 N/A physical interaction ComPPI
PAWR SHMT1 25348397 N/A physical interaction ComPPI
CTTN SHMT1 25348397 N/A physical interaction ComPPI
TTC1 SHMT1 25348397 N/A physical interaction ComPPI
DPYSL5 SHMT1 25348397 N/A physical interaction ComPPI
GSPT2 SHMT1 25348397 N/A physical interaction ComPPI
DEDD SHMT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TSN SHMT1 25348397 N/A physical interaction ComPPI
CSNK2B SHMT1 10549165 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VPS29 SHMT1 25348397 N/A physical interaction ComPPI
SHMT2 SHMT1 25348397 N/A physical interaction ComPPI
SHMT1 PRSS23 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SHMT1 ZC3H4 25348397 N/A physical interaction ComPPI
SHMT1 HSPA1L 25348397 N/A physical interaction ComPPI
SHMT1 NIBAN2 25348397 N/A physical interaction ComPPI
SHMT1 IDE 25348397 N/A physical interaction ComPPI
SHMT1 PGK2 25348397 N/A physical interaction ComPPI
SHMT1 PAICS 25348397 N/A physical interaction ComPPI
SHMT1 PRRC1 25348397 N/A physical interaction ComPPI
SHMT1 ARNT 25348397 N/A physical interaction ComPPI
APEH SHMT1 25348397 N/A physical interaction ComPPI
ATIC SHMT1 25348397 N/A physical interaction ComPPI

Visualization










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