Gene Information gene info

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GENE：IRF4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRF4
FullNmae interferon regulatory factor 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6119
EnsembleID ENSG00000137265
Uniprot Q15306

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRF4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IRF4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IRF4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IRF4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRF4 GO:0000785,GO:0000786,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0002376,GO:0003700,GO:0003713,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005829,GO:0005829,GO:0006338,GO:0006357,GO:0016020,GO:0032733,GO:0032736,GO:0032743,GO:0032753,GO:0034122,GO:0042110,GO:0042832,GO:0043011,GO:0043565,GO:0045622,GO:0045893,GO:0045944,GO:0072540,GO:0120162,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRF4 hsa:3662 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF4 CIITA 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
IRF4 IL6 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
IRF4 IFNGR1 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
IRF4 IFNGR2 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
IRF4 TNF 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
B2M IRF4 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
IRF4 IL1B 12676954 18566416 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 IL12A 19164128 23180781 physical association affinity chromatography technology InnateDB
IRF4 STAT4 14581002 16272311 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
STAT6 IRF4 10601358 16272311 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,pull down InnateDB
SPI1 IRF4 16272311 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IRF4 IRF4 16272311 17785208 18568025 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IRF4 RELA 16272311 17785208 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF4 RELB 16272311 23180781 physical association affinity chromatography technology InnateDB
NFKB1 IRF4 12218129 16272311 17785208 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
REL IRF4 12218129 16272311 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IRF4 TLR4 12676954 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD68 IRF4 12676954 23180781 physical association anti tag coimmunoprecipitation InnateDB
MS4A1 IRF4 12676954 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL4 IRF4 12374808 23180781 physical association electrophoretic mobility supershift assay InnateDB
CIITA IRF4 15242870 21216962 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 NFATC2 12218129 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
NFATC1 IRF4 12218129 23180781 physical association electrophoretic mobility supershift assay InnateDB
SP1 IRF4 12218129 23180781 physical association anti tag coimmunoprecipitation InnateDB
FKBP4 IRF4 10714679 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
IRF4 ISG15 10714679 12055236 23180781 physical association electrophoretic mobility supershift assay InnateDB
FCER2 IRF4 10601358 11342629 23180781 physical association electrophoretic mobility supershift assay InnateDB
IRF4 BCL6 10601358 11342629 17785208 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IRF4 CANX 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 CCNC 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDK6 IRF4 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELL2 IRF4 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 PIM2 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 STAG2 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
SUB1 IRF4 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYC IRF4 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 PRDM1 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
SQLE IRF4 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 SCD 18568025 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 DEF6 12651066 23180781 physical association two hybrid InnateDB
IRF8 IRF4 12055236 23180781 physical association electrophoretic mobility shift assay InnateDB
MYD88 IRF4 18188453 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK2 IRF4 18188453 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 IRF4 18188453 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 CEBPB 19717648 23180781 physical association anti tag coimmunoprecipitation InnateDB
APOBEC3F IRF4 21078663 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 CARM1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 VPS35 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 YTHDC2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 TLK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 ELP1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 IRAK1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 PEG10 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 RIPK2 23180781 24670424 physical association anti tag coimmunoprecipitation,proximity ligation assay InnateDB
IRF4 TRAF6 23180781 24670424 physical association anti tag coimmunoprecipitation,proximity ligation assay InnateDB
IRF4 MYD88 23180781 24670424 physical association anti tag coimmunoprecipitation,proximity ligation assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 IRF4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IRF4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IRF4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IRF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BCL6 IRF4 10601358 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB IRF4 19717648 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IRF4 17018379 trascriptional regulation,stimulation inferred by curator TFlink
RELA IRF4 17018379 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 IRF4 10601358 trascriptional regulation,stimulation inferred by curator TFlink
REL IRF4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 IRF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 IRF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C IRF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 IRF4 20371350 21572407 23446348 25416803 28052011 mrna cleavage,inhibition array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,clip TarBase
URS000040EE1D IRF4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC IRF4 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A IRF4 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 IRF4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FKBP4 IRF4 25361965 interaction type N/A PTMCode2
IRF4 FKBP4 25361965 interaction type N/A PTMCode2
BCL6 IRF4 25361965 interaction type N/A PTMCode2
IRF4 BCL6 25361965 interaction type N/A PTMCode2
STAT6 IRF4 25361965 interaction type N/A PTMCode2
IRF4 STAT6 25361965 interaction type N/A PTMCode2
SPI1 IRF4 25361965 interaction type N/A PTMCode2
IRF4 SPI1 25361965 interaction type N/A PTMCode2
IRF4 NFATC2 25361965 interaction type N/A PTMCode2
NFATC2 IRF4 25361965 interaction type N/A PTMCode2
IRF4 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRF4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 IRF4 25348397 N/A physical interaction ComPPI
BATF IRF4 25348397 N/A physical interaction ComPPI
GIPC2 IRF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPI1 IRF4 10022840 12372320 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SPIB IRF4 10196196 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRF4 NFATC2 11956291 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IRF4 STAT6 10601358 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRF4 PRDM1 11342629 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRF4 FKBP4 10714679 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
IRF4 MYD88 14525934 16236719 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRF4 TRAF2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
IRF4 BCL6 25348397 N/A physical interaction ComPPI
IRF4 HOXC11 25348397 N/A physical interaction ComPPI
IRF4 PROX1 25348397 N/A physical interaction ComPPI
IRF4 HOXB13 25348397 N/A physical interaction ComPPI
IRF4 ETV7 25348397 N/A physical interaction ComPPI
IRF4 PRRC2B 25348397 N/A physical interaction ComPPI
IRF4 CARM1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF4 ELP1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF4 IRAK1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF4 PEG10 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF4 TLK2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF4 YTHDC2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF4 TOP1 25348397 N/A physical interaction ComPPI
IRF4 RIPK2 25348397 N/A physical interaction ComPPI
IRF4 TSEN54 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VPS35 IRF4 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF4 BCOR 24234451 27505670 association chromatin immunoprecipitation assay IntAct
IRF4 CBX8 24234451 27505670 association chromatin immunoprecipitation assay IntAct
IRF4 DEF6 12651066 27898060 N/A N/A OmniPath
IRF4 STAT6 10601358 11342629 27898060 N/A N/A OmniPath
IRF4 RIPK2 18188453 24670424 27898060 N/A N/A OmniPath
IRF4 TRAF6 18188453 24670424 27898060 N/A N/A OmniPath
IRF4 MYD88 16236719 18188453 24670424 27898060 N/A N/A OmniPath
IRF4 IRF5 22378047 27898060 inhibition N/A OmniPath
ROCK2 IRF4 20697158 27898060 stimulant N/A OmniPath
IRF4 IRAK1 21903422 27898060 N/A N/A OmniPath

Visualization










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