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GENE：PCSK6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PCSK6
FullNmae proprotein convertase subtilisin/kexin type 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8569
EnsembleID ENSG00000140479
Uniprot P29122

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PCSK6 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PCSK6 GO:0004175,GO:0004175,GO:0004252,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005783,GO:0005796,GO:0005886,GO:0007354,GO:0007368,GO:0008201,GO:0009100,GO:0009986,GO:0009986,GO:0016020,GO:0016485,GO:0016486,GO:0016486,GO:0030510,GO:0032902,GO:0032940,GO:0034369,GO:0048406,GO:0062023,GO:0062023

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ASCL1 PCSK6 11736660 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
GATA1 PCSK6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PCSK6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PCSK6 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 PCSK6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PCSK6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PCSK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PCSK6 17825503 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 PCSK6 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETV4 PCSK6 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 PCSK6 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PCSK6 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000031602A PCSK6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000486E0B PCSK6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D PCSK6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A PCSK6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 PCSK6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 PCSK6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C PCSK6 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PCSK6 FLG 11380615 25348397 27898060 N/A in vitro ComPPI,OmniPath
PCSK6 CACNA1A 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PCSK6 RXRB 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
RCN3 PCSK6 16433634 25348397 27898060 N/A in vivo ComPPI,OmniPath
VDAC1 PCSK6 24234451 30021884 physical association cross-linking study IntAct

Source Target Pmid Interactiontype Methods Database
URS000075EA9D PCSK6 27087310 direct interaction,inhibition N/A NPInter

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