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GENE：SPC25

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPC25
FullNmae SPC25 component of NDC80 kinetochore complex
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24031
EnsembleID ENSG00000152253
Uniprot Q9HBM1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPC25 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SPC25 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SPC25 GO:0000776,GO:0000776,GO:0005515,GO:0005634,GO:0005829,GO:0005829,GO:0007052,GO:0007059,GO:0007059,GO:0007059,GO:0007094,GO:0008608,GO:0031262,GO:0031262,GO:0031262,GO:0051301

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SPC25 PRDM1 20421211 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 SPC25 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SPC25 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SPC25 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SPC25 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 SPC25 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 SPC25 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000001C659 SPC25 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 SPC25 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 SPC25 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 SPC25 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SPC25 BUB1 25361965 interaction type N/A PTMCode2
BUB1 SPC25 25361965 interaction type N/A PTMCode2
SPC25 ZWINT 25361965 interaction type N/A PTMCode2
ZWINT SPC25 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDC80 SPC25 14525934 14699129 15961401 20360068 24234451 25348397 25416956 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,molecular sieving,physical interaction,mammalian protein protein interaction trap,tandem affinity purification ComPPI,HPRD,IntAct
SNAP29 SPC25 25348397 N/A physical interaction ComPPI
KTN1 SPC25 25348397 N/A physical interaction ComPPI
HGS SPC25 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BUB1 SPC25 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SEC61B SPC25 14525934 25348397 9585408 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MYO18A SPC25 25348397 N/A physical interaction ComPPI
AP2A1 SPC25 25348397 N/A physical interaction ComPPI
EPS15 SPC25 25348397 N/A physical interaction ComPPI
MMS19 SPC25 25348397 N/A physical interaction ComPPI
LRPPRC SPC25 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PMF1 SPC25 25348397 N/A physical interaction ComPPI
EPS15L1 SPC25 25348397 N/A physical interaction ComPPI
LTBR SPC25 25348397 N/A physical interaction ComPPI
KIF2B SPC25 25348397 N/A physical interaction ComPPI
TNKS1BP1 SPC25 25348397 N/A physical interaction ComPPI
ZWINT SPC25 20360068 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
TTK SPC25 25348397 N/A pull down,physical interaction ComPPI
MIS12 SPC25 15371340 20360068 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
DSN1 SPC25 24234451 25348397 26496610 27705803 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
SPC25 SPC24 11179222 11266451 11952896 12408861 14738735 15371542 15728720 15809444 15961401 16765893 18793650 19300438 21075115 22371557 22939629 23334295 23623551 24234451 25230952 25348397 26186194 26496610 27898060 9520439 colocalization,association,physical association affinity chromatography technology,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction,two hybrid array,fluorescence microscopy,two hybrid prey pooling approach ComPPI,IntAct,OmniPath
SPC25 NUF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPC25 NSL1 25348397 N/A physical interaction ComPPI
SPC25 FAM170A 25348397 N/A physical interaction ComPPI
SPC25 SPECC1L 25348397 N/A physical interaction ComPPI
SPC25 KNL1 23334297 24234451 25348397 26496610 association anti tag coimmunoprecipitation,isothermal titration calorimetry,molecular sieving,physical interaction ComPPI,IntAct
SPC25 HDGFL2 25348397 N/A physical interaction ComPPI
SPC25 FCHO2 25348397 N/A physical interaction ComPPI
SPC25 GCC2 25348397 N/A physical interaction ComPPI
SPC25 ATG16L1 25348397 N/A physical interaction ComPPI
SPC25 CUSTOS 25348397 N/A physical interaction ComPPI
SPC25 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SPC25 CSPP1 25348397 N/A physical interaction ComPPI
SPC25 C6ORF141 25348397 N/A physical interaction ComPPI
SPC25 TKT 25348397 N/A physical interaction ComPPI
SPC25 CENPT 23334297 24234451 25348397 physical association isothermal titration calorimetry,molecular sieving ComPPI,IntAct
HSCB SPC25 24234451 24606901 25348397 physical association two hybrid ComPPI,IntAct

Visualization










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