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GENE：MAP4K3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP4K3
FullNmae mitogen-activated protein kinase kinase kinase kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6865
EnsembleID ENSG00000011566
Uniprot Q8IVH8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP4K3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP4K3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP4K3 GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0006468,GO:0007254,GO:0008349,GO:0009411,GO:0034612,GO:0035556,GO:0035556,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP4K3 hsa:8491 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LCP2 MAP4K3 12640133 19909365 20189481 21536650 22786724 23474202 23620508 24343663 24584089 26192618 9765283 interaction type N/A ACSN
MAP4K3 PRKCQ 21983831 26192618 interaction type N/A ACSN
MAP4K3 MAP3K1 11316611 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP4K3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 MAP4K3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 MAP4K3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 MAP4K3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 MAP4K3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MAP4K3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MAP4K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 MAP4K3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000031E12 MAP4K3 23981581 25416803 28099144 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAP4K3 PRKCQ 22135298 phosphorylation N/A PhosphoSite
MAP4K3 MAP4K3 22135298 phosphorylation N/A PhosphoSite
MAP4K3 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP4K3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LCP2 MAP4K3 21983831 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
PCBP1 MAP4K3 24234451 25348397 25852190 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCQ MAP4K3 21983831 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
NCK1 MAP4K3 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 MAP4K3 17474147 20936779 24234451 25348397 physical association peptide array,physical interaction,two hybrid pooling approach ComPPI,IntAct
COPS5 MAP4K3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SORBS1 MAP4K3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
UBB MAP4K3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC MAP4K3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A MAP4K3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 MAP4K3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
NTRK1 MAP4K3 25348397 N/A physical interaction ComPPI
IL13RA1 MAP4K3 25348397 N/A physical interaction ComPPI
BIN1 MAP4K3 11384986 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAPB MAP4K3 25348397 N/A physical interaction ComPPI
MAP4K5 MAP4K3 25348397 N/A physical interaction ComPPI
SH3GL2 MAP4K3 11384986 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SH3RF1 MAP4K3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP4K3 ITSN2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP4K3 GAN 25348397 N/A physical interaction ComPPI
MAP4K3 MAP3K1 27898060 9820741 stimulant N/A OmniPath
MAP4K3 PRKCQ 11772397 16009340 16252004 21983831 27898060 stimulant N/A OmniPath
MAP4K3 MAPK14 27898060 8622669 stimulant N/A OmniPath
MAP3K4 MAP4K3 27898060 9305639 stimulant N/A OmniPath
MAP3K3 MAP4K3 27898060 9162092 stimulant N/A OmniPath

Visualization










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