GENE:MRTFA
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MRTFA |
| FullNmae | myocardin related transcription factor A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14334 |
| EnsembleID | ENSG00000196588 |
| Uniprot | Q969V6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MRTFA | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MRTFA | GO:0003713,GO:0003713,GO:0003713,GO:0003779,GO:0003785,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0030036,GO:0043522,GO:0044319,GO:0045944,GO:0045944,GO:0051145,GO:0051145,GO:1902895 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MRTFA | RELA | 14527995 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MRTFA | EGR1 | 19374776 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MRTFA | CREB1 | 18160048 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MRTFA | LYL1 | 18160048 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MRTFA | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA1 | MRTFA | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MRTFA | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | MRTFA | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | MRTFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPKAPK2 | MRTFA | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK3 | MRTFA | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK14 | MRTFA | 22135298 | phosphorylation | N/A | PhosphoSite |
| CDK2 | MRTFA | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK1 | MRTFA | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | MRTFA | 14525934 16098147 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| KPNA3 | MRTFA | 20818336 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| CEP19 | MRTFA | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| LCA5 | MRTFA | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| ACTB | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| SUMO1 | MRTFA | 14525934 16098147 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| NCOA3 | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| EP300 | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| SMAD3 | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| SRF | MRTFA | 12397177 14525934 14565952 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| GSK3B | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| MVP | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| SMARCA4 | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| MYC | MRTFA | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| XPO1 | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| SUPT16H | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| SSRP1 | MRTFA | 25348397 | N/A | physical interaction | ComPPI |
| MYOCD | MRTFA | 14525934 14970199 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| MRTFA | MRTFB | 14525934 14565952 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| MRTFA | KDM3A | 25348397 | N/A | physical interaction | ComPPI |
| MRTFA | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| MRTFA | KIAA0753 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| MRTFA | CEP63 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| MRTFA | RPGRIP1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| MRTFA | TCTN1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| MRTFA | DNMT1 | 25348397 | N/A | physical interaction | ComPPI |
| MRTFA | BCL7A | 25348397 | N/A | physical interaction | ComPPI |
| MRTFA | MRTFA | 14525934 14565952 | N/A | experimental interaction detection | HPRD |
| FUNDC2 | MRTFA | 24234451 30021884 | physical association | cross-linking study | IntAct |
| MAPK3 | MRTFA | 18694962 22139079 27898060 | inhibition | N/A | OmniPath |
| MAPK1 | MRTFA | 18694962 22139079 27898060 | inhibition | N/A | OmniPath |
| MRTFA | SRF | 12397177 14565952 15610731 17599918 21673106 21965288 27898060 | stimulant | N/A | OmniPath |
