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GENE：IST1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IST1
FullNmae IST1 factor associated with ESCRT-III
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28977
EnsembleID ENSG00000182149
Uniprot P53990

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IST1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IST1 GO:0000785,GO:0005515,GO:0005576,GO:0005635,GO:0005793,GO:0005813,GO:0005829,GO:0005829,GO:0008104,GO:0008104,GO:0009838,GO:0009838,GO:0015031,GO:0019076,GO:0019904,GO:0030496,GO:0035578,GO:0036258,GO:0043231,GO:0044877,GO:0045184,GO:0045296,GO:0045862,GO:0046745,GO:0048668,GO:0048672,GO:0051301,GO:0061640,GO:0070062,GO:0090541,GO:0090543,GO:1904903

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IST1 hsa:9798 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APEH IST1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR IST1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IST1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 IST1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IST1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 IST1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000171FEC IST1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC IST1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004A6E26 IST1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C IST1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 IST1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
VPS4B IST1 25348397 N/A physical interaction ComPPI
CAPN7 IST1 20849418 24234451 24953135 25348397 25416956 27898060 colocalization,physical association anti tag coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
IQGAP3 IST1 25348397 N/A physical interaction ComPPI
ATXN1 IST1 14525934 16713569 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
HEY2 IST1 25348397 N/A physical interaction ComPPI
AP1G2 IST1 25348397 N/A physical interaction ComPPI
NF2 IST1 25348397 N/A physical interaction ComPPI
FZR1 IST1 25348397 N/A physical interaction ComPPI
RAB7A IST1 25348397 N/A physical interaction ComPPI
DLD IST1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CDH1 IST1 25348397 N/A physical interaction ComPPI
HSPA5 IST1 25348397 N/A physical interaction ComPPI
ATP6AP2 IST1 25348397 N/A physical interaction ComPPI
CLTC IST1 25348397 N/A physical interaction ComPPI
CDC20 IST1 25348397 N/A physical interaction ComPPI
ATP6V1B1 IST1 25348397 N/A physical interaction ComPPI
VCAM1 IST1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 IST1 25348397 N/A physical interaction ComPPI
TIMM13 IST1 25348397 N/A physical interaction ComPPI
TFG IST1 25348397 N/A physical interaction ComPPI
UBQLN1 IST1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VPS4A IST1 18032582 18032584 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATP6V1A IST1 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RAB5C IST1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANAPC2 IST1 25348397 N/A physical interaction ComPPI
CHMP4B IST1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP47 IST1 25348397 N/A physical interaction ComPPI
CHMP1B IST1 19477918 19525971 25348397 26344197 26634441 27898060 N/A transmission electron microscopy,physical interaction,electron tomography,surface plasmon resonance array ComPPI,OmniPath
ERGIC1 IST1 25348397 N/A physical interaction ComPPI
APEH IST1 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
SPAST IST1 25348397 N/A physical interaction ComPPI
IST1 FN1 25348397 N/A physical interaction ComPPI
IST1 BTF3L4 25348397 N/A physical interaction ComPPI
IST1 CHMP1A 25348397 N/A physical interaction ComPPI
IST1 MIB2 25348397 N/A physical interaction ComPPI
IST1 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAT1A IST1 25348397 N/A physical interaction ComPPI

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