GENE：RFC2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RFC2 |
| FullNmae | replication factor C subunit 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9970 |
| EnsembleID | ENSG00000049541 |
| Uniprot | P35250 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RFC2 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RFC2 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RFC2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RFC2 | GO:0003677,GO:0003689,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0005663,GO:0005663,GO:0006261,GO:0006261,GO:0006281,GO:0016887,GO:0017116,GO:0019899,GO:0031390,GO:0032508,GO:1900264 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RFC2 | hsa:5982 | path:hsa03030 | DNA replication - Homo sapiens (human) |
| RFC2 | hsa:5982 | path:hsa03410 | Base excision repair - Homo sapiens (human) |
| RFC2 | hsa:5982 | path:hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| RFC2 | hsa:5982 | path:hsa03430 | Mismatch repair - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RFC1 | RFC2 | 14624239 26192618 | interaction type | N/A | ACSN |
| RFC2 | RFC3 | 14624239 26192618 | interaction type | N/A | ACSN |
| RFC2 | RFC5 | 14624239 26192618 | interaction type | N/A | ACSN |
| RFC4 | RFC2 | 14624239 26192618 | interaction type | N/A | ACSN |
| RFC2 | PCNA | 26192618 | interaction type | N/A | ACSN |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | RFC2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | RFC2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | RFC2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | RFC2 | 12747840 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | RFC2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | RFC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001C770D | RFC2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000039E1E1 | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000221168 | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003380CC | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045147B | RFC2 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A513 | RFC2 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000345DEB | RFC2 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | RFC2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000049704B | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043C1C3 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D4175 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FBC84 | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC4BD | RFC2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC864 | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000183BED | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000030F801 | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EE7F0 | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F8DA | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | RFC2 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RFC2 | RPA1 | 25361965 | interaction type | N/A | PTMCode2 |
| RPA1 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | LIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| LIG1 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | BRD2 | 25361965 | interaction type | N/A | PTMCode2 |
| BRD2 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | RFC4 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC4 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | FEN1 | 25361965 | interaction type | N/A | PTMCode2 |
| FEN1 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | DSCC1 | 25361965 | interaction type | N/A | PTMCode2 |
| DSCC1 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | PCNA | 25361965 | interaction type | N/A | PTMCode2 |
| PCNA | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | RAD17 | 25361965 | interaction type | N/A | PTMCode2 |
| RAD17 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | RFC5 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC5 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KRT18 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| SNW1 | RFC2 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDC5L | RFC2 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DAXX | RFC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| USP20 | RFC2 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PCNA | RFC2 | 14525934 24234451 25348397 26496610 8093561 | association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| PSMC3 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| PSMC6 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| TP53BP1 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| GABARAPL2 | RFC2 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| KEAP1 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| EXOSC1 | RFC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RPL10 | RFC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NFATC1 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKDC | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| JUN | RFC2 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| COPS5 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| PAXIP1 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKAR1A | RFC2 | 14525934 15096576 15655353 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| UBC | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| RPA1 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | RFC5 | 14525934 24234451 25348397 8692848 9228079 9488738 | physical association | two hybrid,cosedimentation in solution,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| RFC2 | RFC4 | 14525934 15655353 24234451 25348397 8692848 9228079 9488738 | association,physical association | two hybrid,coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| RFC2 | RFC1 | 14525934 15655353 24234451 25348397 9488738 | association,physical association | coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| RFC2 | RAD17 | 14624239 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RFC2 | CHTF18 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | BRD4 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | GTF2F1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | PMS2 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | PMS2CL | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | PMS1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | CHD1L | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | DDX12P | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | DDX11 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | MYC | 17314511 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| RFC2 | SMARCAD1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | CAND1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | RFC3 | 24234451 25348397 9488738 | physical association | cosedimentation in solution,physical interaction | ComPPI,IntAct |
| RFC2 | PURA | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | BARD1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | BRCA1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | ECT2 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | MDC1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | RTCB | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | DDX1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | FLII | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | LRRFIP1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | RPA3 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | RPA2 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | CEP76 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | CCDC8 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | LIMCH1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | SETD3 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | NT5E | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | DSCC1 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | GINS3 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | IFI16 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | CEP164 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| RFC2 | HNRNPU | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RFC2 | NOP56 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RFC2 | NFATC2 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | MCM9 | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | CFTR | 25348397 | N/A | physical interaction | ComPPI |
| RFC2 | PHLDA3 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RFC2 | PITX2 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RFC2 | ESR2 | 21182203 24234451 25348397 | association | cosedimentation through density gradient | ComPPI,IntAct |
| RFC2 | KDM4A | 23871696 24234451 25348397 | association | pull down | ComPPI,IntAct |
| RFC2 | RRP1B | 20926688 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| RAD18 | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| H3C1 | RFC2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RTRAF | RFC2 | 25348397 | N/A | physical interaction | ComPPI |
| HSCB | RFC2 | 24234451 25348397 28380382 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |