Gene Information gene info

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GENE：TPM4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TPM4
FullNmae tropomyosin 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12013
EnsembleID ENSG00000167460
Uniprot P67936

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TPM4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TPM4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TPM4 GO:0001649,GO:0001725,GO:0002102,GO:0005509,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0005925,GO:0006936,GO:0007015,GO:0008307,GO:0016020,GO:0030863,GO:0042802,GO:0042803,GO:0046982,GO:0051015,GO:0051015,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TPM4 hsa:7171 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
TPM4 hsa:7171 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
TPM4 hsa:7171 path:hsa04814 Motor proteins - Homo sapiens (human)
TPM4 hsa:7171 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
TPM4 hsa:7171 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL7R TPM4 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
TPM4 UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR TPM4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 TPM4 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 TPM4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 TPM4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TPM4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TPM4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TPM4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TPM4 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C TPM4 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 TPM4 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TPM4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TPM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 TPM4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 TPM4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000041FA2C TPM4 22012620 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00001F0C23 TPM4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001799A3 TPM4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 TPM4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000049FAE8 TPM4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075BEA7 TPM4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D TPM4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001B9F58 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD231 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006DA05 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000043F369 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001B968D TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 TPM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004CFC54 TPM4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000FFC8B TPM4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002D0FC3 TPM4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 TPM4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 TPM4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C TPM4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 TPM4 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRIP6 TPM4 25361965 interaction type N/A PTMCode2
TPM4 TRIP6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK TPM4 25348397 N/A physical interaction ComPPI
MAPRE1 TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TXN2 TPM4 25348397 N/A physical interaction ComPPI
PPP1CC TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1CB TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MCM2 TPM4 25348397 N/A physical interaction ComPPI
COX5A TPM4 25348397 N/A physical interaction ComPPI
CAVIN3 TPM4 25348397 N/A physical interaction ComPPI
PACSIN1 TPM4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DUSP12 TPM4 24234451 25348397 28330616 physical association pull down ComPPI,IntAct
PPP1R3C TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
PICK1 TPM4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZYX TPM4 25348397 N/A physical interaction ComPPI
SP1 TPM4 25348397 N/A physical interaction ComPPI
SNRNP70 TPM4 25348397 N/A physical interaction ComPPI
TPM2 TPM4 25348397 N/A physical interaction ComPPI
FLNA TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTN4 TPM4 25348397 N/A physical interaction ComPPI
SERPINH1 TPM4 25348397 N/A physical interaction ComPPI
ACTN1 TPM4 25348397 N/A physical interaction ComPPI
NTRK1 TPM4 25348397 N/A physical interaction ComPPI
PSMA1 TPM4 25348397 N/A physical interaction ComPPI
PSMA6 TPM4 25348397 N/A physical interaction ComPPI
TRIP6 TPM4 25348397 N/A two hybrid,physical interaction ComPPI
DUSP7 TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
IQGAP1 TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFTR TPM4 25348397 N/A physical interaction ComPPI
PDLIM7 TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTN2 TPM4 25348397 N/A physical interaction ComPPI
TPM3 TPM4 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMD1 TPM4 25348397 N/A physical interaction ComPPI
MYO18A TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TBCD TPM4 25348397 N/A physical interaction ComPPI
ARRB1 TPM4 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRSF2 TPM4 25348397 N/A physical interaction ComPPI
SNAPIN TPM4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATP1A1 TPM4 25348397 N/A physical interaction ComPPI
CDK2 TPM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR TPM4 25348397 N/A physical interaction ComPPI
UBE2A TPM4 25348397 N/A physical interaction ComPPI
SIRT1 TPM4 25348397 N/A physical interaction ComPPI
PSMD2 TPM4 25348397 N/A physical interaction ComPPI
TCERG1 TPM4 25348397 N/A physical interaction,in vitro ComPPI
PYCARD TPM4 24234451 24407287 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB9A TPM4 24234451 25348397 29568061 association pull down ComPPI,IntAct
PPP6C TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
PRKN TPM4 25348397 N/A physical interaction ComPPI
HDAC8 TPM4 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCMT1 TPM4 25348397 N/A physical interaction ComPPI
SMURF1 TPM4 25348397 N/A physical interaction ComPPI
OSTF1 TPM4 25348397 N/A physical interaction ComPPI
ILF2 TPM4 25348397 N/A physical interaction ComPPI
CDC25C TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
AKT1 TPM4 20856200 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CAP1 TPM4 25348397 N/A physical interaction ComPPI
CDH2 TPM4 25348397 N/A physical interaction ComPPI
ILKAP TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
DUSP19 TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
TPM4 PACSIN2 25348397 N/A physical interaction ComPPI
TPM4 TPM1 25348397 N/A physical interaction ComPPI
TPM4 SRXN1 25348397 N/A physical interaction ComPPI
TPM4 DBN1 25348397 N/A physical interaction ComPPI
TPM4 G3BP1 25348397 N/A physical interaction ComPPI
TPM4 SULT1A1 25348397 N/A physical interaction ComPPI
TPM4 ILF3 25348397 N/A physical interaction ComPPI
TPM4 TELO2 25348397 N/A physical interaction ComPPI
TPM4 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM4 CORO1C 25348397 N/A physical interaction ComPPI
TPM4 DCTN2 25348397 N/A physical interaction ComPPI
TPM4 PSMC2 25348397 N/A physical interaction ComPPI
TPM4 PAN2 25348397 N/A physical interaction ComPPI
TPM4 SHTN1 25348397 N/A physical interaction ComPPI
TPM4 TP53 25348397 N/A physical interaction ComPPI
TPM4 LNX1 25348397 N/A physical interaction ComPPI
TPM4 ATP5PB 25348397 N/A physical interaction ComPPI
TPM4 CENPE 25348397 N/A physical interaction ComPPI
TPM4 MYH7B 25348397 N/A physical interaction ComPPI
TPM4 NDUFB10 25348397 N/A physical interaction ComPPI
TPM4 ADD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM4 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM4 SLC33A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM4 ANLN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM4 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM4 CFAP97 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM4 ZNF131 25348397 N/A physical interaction ComPPI
TPM4 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPM4 HACD1 24234451 25348397 28330616 association pull down ComPPI,IntAct
TPM4 PPM1D 24234451 25348397 28330616 association pull down ComPPI,IntAct
TPM4 PTPRCAP 24234451 25348397 28330616 association pull down ComPPI,IntAct
TPM4 PPTC7 24234451 25348397 28330616 association pull down ComPPI,IntAct
TPM4 PHPT1 24234451 25348397 28330616 physical association pull down ComPPI,IntAct
TPM4 HK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 TPM4 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CKB TPM4 25348397 N/A physical interaction ComPPI
FASN TPM4 25348397 N/A physical interaction ComPPI
COX4I1 TPM4 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DUSP21 TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
WTAP TPM4 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 TPM4 24234451 29507755 association anti tag coimmunoprecipitation IntAct
ESR2 TPM4 21951318 24234451 association anti tag coimmunoprecipitation IntAct
IL7R TPM4 20167604 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B7C1F TPM4 27087310 direct interaction,inhibition N/A NPInter

Visualization










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