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GENE：ATP1A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATP1A1
FullNmae ATPase Na+/K+ transporting subunit alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:799
EnsembleID ENSG00000163399
Uniprot P05023

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATP1A1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATP1A1 GO:0002026,GO:0002028,GO:0005391,GO:0005391,GO:0005391,GO:0005391,GO:0005515,GO:0005524,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005890,GO:0005890,GO:0005890,GO:0005890,GO:0005890,GO:0006883,GO:0006883,GO:0006883,GO:0008217,GO:0009410,GO:0010248,GO:0014069,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0016791,GO:0016887,GO:0030007,GO:0030007,GO:0030007,GO:0030315,GO:0030424,GO:0030955,GO:0031090,GO:0031402,GO:0031947,GO:0032991,GO:0036126,GO:0036376,GO:0036376,GO:0036376,GO:0036376,GO:0042383,GO:0042383,GO:0042470,GO:0045121,GO:0045822,GO:0045823,GO:0045989,GO:0046982,GO:0051087,GO:0055119,GO:0060342,GO:0070062,GO:0071383,GO:0086002,GO:0086009,GO:0086013,GO:0086064,GO:1902600,GO:1902600,GO:1903416,GO:1903561,GO:1990239,GO:1990573,GO:1990573,GO:1990573,GO:1990573

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATP1A1 hsa:476 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04911 Insulin secretion - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04970 Salivary secretion - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04974 Protein digestion and absorption - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04976 Bile secretion - Homo sapiens (human)
ATP1A1 hsa:476 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK1 ATP1A1 15069082 23180781 phosphorylation reaction protein kinase assay InnateDB
MAPK3 ATP1A1 15069082 23180781 phosphorylation reaction protein kinase assay InnateDB
EGFR ATP1A1 16799092 23180781 physical association pull down InnateDB
TPT1 ATP1A1 16730713 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 ATP1A1 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ATP1A1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ATP1A1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 ATP1A1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ATP1A1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C ATP1A1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ATP1A1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ATP1A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 ATP1A1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC ATP1A1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ATP1A1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 ATP1A1 21512034 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000007FBA ATP1A1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 ATP1A1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005CF5F ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 ATP1A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000338542 ATP1A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000156390 ATP1A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 ATP1A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 ATP1A1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00007455B8 ATP1A1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA ATP1A1 22135298 phosphorylation N/A PhosphoSite
SRC ATP1A1 22135298 phosphorylation N/A PhosphoSite
ATP1A1 FXYD1 25361965 interaction type N/A PTMCode2
FXYD1 ATP1A1 25361965 interaction type N/A PTMCode2
FXYD7 ATP1A1 25361965 interaction type N/A PTMCode2
ATP1A1 FXYD7 25361965 interaction type N/A PTMCode2
ADD1 ATP1A1 25361965 interaction type N/A PTMCode2
ATP1A1 ADD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 ATP1A1 25348397 N/A physical interaction ComPPI
RPN1 ATP1A1 25348397 N/A physical interaction ComPPI
FXYD7 ATP1A1 12093728 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CFL1 ATP1A1 11139403 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PPP2R1A ATP1A1 25348397 N/A physical interaction ComPPI
FASTKD3 ATP1A1 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MRPL40 ATP1A1 25348397 N/A physical interaction ComPPI
HIPK4 ATP1A1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ERBB2 ATP1A1 24189400 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
MAPK1 ATP1A1 25348397 N/A physical interaction ComPPI
EZH2 ATP1A1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKCA ATP1A1 25348397 N/A physical interaction ComPPI
SRC ATP1A1 21278788 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CD81 ATP1A1 24234451 25348397 30024968 association anti bait coimmunoprecipitation ComPPI,IntAct
MAPK3 ATP1A1 14525934 15069082 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
JUN ATP1A1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
GTF2F2 ATP1A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SMAD2 ATP1A1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NELFB ATP1A1 25348397 N/A physical interaction ComPPI
CUL3 ATP1A1 25348397 N/A physical interaction ComPPI
HGS ATP1A1 25348397 N/A physical interaction ComPPI
UBC ATP1A1 25348397 N/A physical interaction ComPPI
NTRK1 ATP1A1 25348397 N/A physical interaction ComPPI
PKD1 ATP1A1 25348397 N/A physical interaction ComPPI
ILK ATP1A1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNX6 ATP1A1 16730713 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PKD2 ATP1A1 25348397 N/A physical interaction ComPPI
PHB ATP1A1 25348397 N/A physical interaction ComPPI
MYC ATP1A1 17314511 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TNFRSF1A ATP1A1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NELFCD ATP1A1 25348397 N/A physical interaction ComPPI
CAD ATP1A1 25348397 N/A physical interaction ComPPI
MAPK6 ATP1A1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC1 ATP1A1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IRAK1 ATP1A1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP2A2 ATP1A1 25348397 N/A physical interaction ComPPI
NDRG1 ATP1A1 14525934 17220478 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TPM3 ATP1A1 25348397 N/A physical interaction ComPPI
PDHA1 ATP1A1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB1A ATP1A1 25348397 N/A physical interaction ComPPI
RAB2A ATP1A1 25348397 N/A physical interaction ComPPI
CLTC ATP1A1 25348397 N/A physical interaction ComPPI
HUWE1 ATP1A1 25348397 N/A physical interaction ComPPI
VDAC2 ATP1A1 25348397 N/A physical interaction ComPPI
SNAPIN ATP1A1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SSR2 ATP1A1 25348397 N/A physical interaction ComPPI
ATP1A1 FXYD2 11832419 25348397 27898060 N/A in vivo ComPPI,OmniPath
ATP1A1 FXYD1 14525934 14597563 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ATP1A1 TPT1 14525934 15383549 16730713 21278788 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
ATP1A1 EGFR 14525934 16799092 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
ATP1A1 ADD1 10516168 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ATP1A1 HDAC5 25348397 N/A physical interaction ComPPI
ATP1A1 CDK9 25348397 N/A physical interaction ComPPI
ATP1A1 NELFA 25348397 N/A physical interaction ComPPI
ATP1A1 SIRT7 25348397 N/A physical interaction ComPPI
ATP1A1 FBXO25 25348397 N/A physical interaction ComPPI
ATP1A1 CDK2 25348397 N/A physical interaction ComPPI
ATP1A1 AKT1 25348397 N/A physical interaction ComPPI
ATP1A1 A2M 25348397 N/A physical interaction ComPPI
ATP1A1 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 MMS19 25348397 N/A physical interaction ComPPI
ATP1A1 CLN3 25348397 N/A physical interaction ComPPI
ATP1A1 ADRB2 25348397 N/A physical interaction ComPPI
ATP1A1 ATP4A 25348397 N/A physical interaction ComPPI
ATP1A1 DYRK4 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ATP1A1 CDK20 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ATP1A1 FBXO6 25348397 N/A physical interaction ComPPI
ATP1A1 LGR4 25348397 N/A physical interaction ComPPI
ATP1A1 STAU1 25348397 N/A physical interaction ComPPI
ATP1A1 SPRTN 25348397 N/A physical interaction ComPPI
ATP1A1 CUL7 25348397 N/A physical interaction ComPPI
ATP1A1 CCDC8 25348397 N/A physical interaction ComPPI
ATP1A1 ZNRF1 25348397 N/A physical interaction ComPPI
ATP1A1 ZNRF2 25348397 N/A physical interaction ComPPI
ATP1A1 LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 PPT1 25348397 N/A physical interaction ComPPI
ATP1A1 RPS6KB2 25348397 N/A physical interaction ComPPI
ATP1A1 ACADM 25348397 N/A physical interaction ComPPI
ATP1A1 AFG3L2 25348397 N/A physical interaction ComPPI
ATP1A1 ATP1B1 24234451 25012180 25348397 30021884 association,physical association anti bait coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
ATP1A1 ATP1B2 25348397 N/A physical interaction ComPPI
ATP1A1 ATP1B3 25348397 N/A physical interaction ComPPI
ATP1A1 ATP2B1 25348397 N/A physical interaction ComPPI
ATP1A1 ATP2B4 25348397 N/A physical interaction ComPPI
ATP1A1 ATP6V0D1 25348397 N/A physical interaction ComPPI
ATP1A1 CCT6A 25348397 N/A physical interaction ComPPI
ATP1A1 CCT8 25348397 N/A physical interaction ComPPI
ATP1A1 CLTCL1 25348397 N/A physical interaction ComPPI
ATP1A1 HADHB 25348397 N/A physical interaction ComPPI
ATP1A1 HSD17B12 25348397 N/A physical interaction ComPPI
ATP1A1 LMAN1 25348397 N/A physical interaction ComPPI
ATP1A1 MTCH1 25348397 N/A physical interaction ComPPI
ATP1A1 MTCH2 25348397 N/A physical interaction ComPPI
ATP1A1 NDUFS1 25348397 N/A physical interaction ComPPI
ATP1A1 RAB1C 25348397 N/A physical interaction ComPPI
ATP1A1 RAB1B 25348397 N/A physical interaction ComPPI
ATP1A1 ATP5F1C 25348397 N/A physical interaction ComPPI
ATP1A1 ATP5MG 25348397 N/A physical interaction ComPPI
ATP1A1 ATP6V1A 25348397 N/A physical interaction ComPPI
ATP1A1 CCT7 25348397 N/A physical interaction ComPPI
ATP1A1 CYB5B 25348397 N/A physical interaction ComPPI
ATP1A1 CYC1 25348397 N/A physical interaction ComPPI
ATP1A1 DDOST 25348397 N/A physical interaction ComPPI
ATP1A1 EIF3B 25348397 N/A physical interaction ComPPI
ATP1A1 IPO5 25348397 N/A physical interaction ComPPI
ATP1A1 ITGA5 25348397 N/A physical interaction ComPPI
ATP1A1 NDUFB8 25348397 N/A physical interaction ComPPI
ATP1A1 NDUFS4 25348397 N/A physical interaction ComPPI
ATP1A1 NDUFV1 25348397 N/A physical interaction ComPPI
ATP1A1 PC 25348397 N/A physical interaction ComPPI
ATP1A1 SLC25A3 25348397 N/A physical interaction ComPPI
ATP1A1 TECR 25348397 N/A physical interaction ComPPI
ATP1A1 TMCO1 25348397 N/A physical interaction ComPPI
ATP1A1 TMED2 25348397 N/A physical interaction ComPPI
ATP1A1 TPM4 25348397 N/A physical interaction ComPPI
ATP1A1 UQCRC2 25348397 N/A physical interaction ComPPI
ATP1A1 UQCRQ 25348397 N/A physical interaction ComPPI
ATP1A1 VDAC3 25348397 N/A physical interaction ComPPI
ATP1A1 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ATP1A1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ATP1A1 AHSA1 25348397 N/A physical interaction ComPPI
ATP1A1 NCSTN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 TMEM63B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 YIPF5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 MBOAT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP1A1 SKI 25348397 N/A physical interaction ComPPI
ATP1A1 CRY2 25348397 N/A physical interaction ComPPI
ATP1A1 ESRRB 25348397 N/A physical interaction ComPPI
ATP1A1 NEPRO 25348397 N/A physical interaction ComPPI
ATP1A1 ZNF746 25348397 N/A physical interaction ComPPI
ATP1A1 CYLD 25348397 N/A physical interaction ComPPI
ATP1A1 NCDN 25348397 N/A physical interaction ComPPI
ATP1A1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP1A1 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP1A1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP1A1 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP1A1 TRADD 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP1A1 AGO1 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATP1A1 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATP1A1 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
ATP1A1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
ATP1A1 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
ATP1A1 SLC4A1 24234451 25012180 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ATP1A1 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP1A1 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 ATP1A1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK4 ATP1A1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ECPAS ATP1A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GPR35 ATP1A1 24234451 28298427 physical association ubiquitin reconstruction IntAct
ATP1A1 NCKAP5L 24234451 30021884 physical association cross-linking study IntAct
ATP1A1 B4GALT2 24234451 30021884 physical association cross-linking study IntAct
ALDH7A1 ATP1A1 24234451 30021884 physical association cross-linking study IntAct
ZFHX4 ATP1A1 24234451 30021884 physical association cross-linking study IntAct
PRKACA ATP1A1 15972390 27898060 N/A N/A OmniPath
EGFR ATP1A1 16799092 24797263 27898060 N/A N/A OmniPath
MAPK3 ATP1A1 15069082 27898060 N/A N/A OmniPath
MAPK1 ATP1A1 15069082 27898060 N/A N/A OmniPath

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