Gene Information gene info

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GENE：CAPNS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CAPNS1
FullNmae calpain small subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1481
EnsembleID ENSG00000126247
Uniprot P04632

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CAPNS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CAPNS1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CAPNS1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CAPNS1 GO:0004198,GO:0005509,GO:0005515,GO:0005829,GO:0005829,GO:0005886,GO:0006508,GO:0008284,GO:0016020,GO:0016241,GO:0070062,GO:0110158,GO:0110158,GO:0110158

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CAPNS1 hsa:826 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CAPNS1 XIAP 12121983 23180781 biochemical protease assay InnateDB
IL7R CAPNS1 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
CAPNS1 FLG 19286660 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CAPNS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C CAPNS1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CAPNS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CAPNS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CAPNS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NRF1 CAPNS1 18234454 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L1 CAPNS1 18234454 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE CAPNS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 CAPNS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F CAPNS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 CAPNS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000048BA36 CAPNS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD CAPNS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB CAPNS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B CAPNS1 23622248 25416803 26701625 mrna cleavage,inhibition clip,clash TarBase
URS0000157026 CAPNS1 23622248 25416803 27994509 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clash,miRNA interference luciferase reporter assay TarBase
URS00001597DC CAPNS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 CAPNS1 25416803 27994509 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001F0C23 CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171FEC CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000047E28E CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019907A CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000137EDE CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AB32B CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006097A6 CAPNS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E78D3 CAPNS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00005D35D9 CAPNS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000055929F CAPNS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000214763 CAPNS1 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GNAI3 CAPNS1 25348397 N/A physical interaction ComPPI
PAK2 CAPNS1 25348397 N/A physical interaction ComPPI
DRG1 CAPNS1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
YWHAG CAPNS1 25348397 N/A physical interaction ComPPI
YWHAQ CAPNS1 25348397 N/A physical interaction ComPPI
CAPNS1 CAST 12684003 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAPNS1 CAPN1 12591934 14525934 19712109 24234451 25348397 26496610 cleavage reaction,association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,protease assay,in vivo ComPPI,HPRD,IntAct
CAPNS1 CAPN2 10639123 10666632 11517928 11673052 14525934 18519038 24234451 25348397 physical association experimental interaction detection,nuclear magnetic resonance,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
CAPNS1 IL2RG 14525934 25348397 27898060 9326644 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
CAPNS1 ARHGEF6 14525934 15611136 25348397 27898060 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
CAPNS1 CDK4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 RAB1A 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 TERF1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 LRRCC1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 GNB2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 GET4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 ATP5MF 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 ARR3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CAPNS1 RUVBL1 25348397 N/A physical interaction ComPPI
CAPNS1 MEPCE 25348397 N/A physical interaction ComPPI
CAPNS1 POU5F1 25348397 N/A physical interaction ComPPI
CAPNS1 CSPG4 25348397 N/A physical interaction ComPPI
CAPNS1 FN1 25348397 N/A physical interaction ComPPI
CAPNS1 VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
CAPNS1 ITGA4 25348397 N/A physical interaction ComPPI
CAPNS1 ADRB2 25348397 N/A physical interaction ComPPI
CAPNS1 TRAF5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAPNS1 STAT3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAPNS1 PPARGC1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAPNS1 ALDH7A1 25348397 N/A physical interaction ComPPI
CAPNS1 APEX1 25348397 N/A physical interaction ComPPI
CAPNS1 ASNS 25348397 N/A physical interaction ComPPI
CAPNS1 EIF5 25348397 N/A physical interaction ComPPI
CAPNS1 FERMT2 25348397 N/A physical interaction ComPPI
CAPNS1 GAPDH 25348397 N/A physical interaction ComPPI
CAPNS1 STK26 25348397 N/A physical interaction ComPPI
CAPNS1 MYO1E 25348397 N/A physical interaction ComPPI
CAPNS1 OGFOD1 25348397 N/A physical interaction ComPPI
CAPNS1 PTMA 25348397 N/A physical interaction ComPPI
CAPNS1 TBCB 25348397 N/A physical interaction ComPPI
CAPNS1 DCPS 25348397 N/A physical interaction ComPPI
CAPNS1 ISOC1 25348397 N/A physical interaction ComPPI
CAPNS1 MAT2A 25348397 N/A physical interaction ComPPI
CAPNS1 MAT2B 25348397 N/A physical interaction ComPPI
CAPNS1 PAFAH1B1 25348397 N/A physical interaction ComPPI
CAPNS1 PDIA4 25348397 N/A physical interaction ComPPI
CAPNS1 PPP1CA 25348397 N/A physical interaction ComPPI
CAPNS1 PLPBP 25348397 N/A physical interaction ComPPI
CAPNS1 YWHAE 25348397 N/A physical interaction ComPPI
CAPNS1 YWHAH 25348397 N/A physical interaction ComPPI
CAPNS1 YWHAZ 25348397 N/A physical interaction ComPPI
CAPNS1 CDC20 25348397 N/A physical interaction ComPPI
CAPNS1 NEDD1 25348397 N/A physical interaction ComPPI
CAPNS1 TUBGCP2 25348397 N/A physical interaction ComPPI
CAPNS1 TUBGCP3 25348397 N/A physical interaction ComPPI
CAPNS1 HUWE1 25348397 N/A physical interaction ComPPI
CAPNS1 AGTRAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAPNS1 USP1 25348397 N/A physical interaction ComPPI
CAPNS1 KNG1 25348397 N/A physical interaction ComPPI
CAPNS1 FNTB 25348397 N/A physical interaction ComPPI
CAPNS1 TNF 25348397 N/A physical interaction ComPPI
CAPNS1 CAPNS2 25348397 N/A physical interaction ComPPI
CAPNS1 DUSP19 25348397 N/A physical interaction ComPPI
CAPNS1 C8ORF37 24234451 25348397 27173435 physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CAPNS1 CFTR 17110338 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CAPNS1 RASA1 18761085 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,competition binding ComPPI,IntAct,OmniPath
CAPNS1 HTR7 19486527 24234451 25348397 association tandem affinity purification ComPPI,IntAct
F2RL1 CAPNS1 24234451 28298427 physical association ubiquitin reconstruction IntAct
CAPNS1 XIAP 12121983 27898060 N/A N/A OmniPath
IL7R CAPNS1 20167604 27898060 N/A N/A OmniPath
CAPNS1 CAPN2 10639123 10666632 11517928 11673052 16597616 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BC939 CAPNS1 27087310 direct interaction,inhibition N/A NPInter

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