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GENE：IL3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL3
FullNmae interleukin 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6011
EnsembleID ENSG00000164399
Uniprot P08700

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL3 GO:0005125,GO:0005135,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006955,GO:0007267,GO:0007399,GO:0008083,GO:0008284,GO:0008284,GO:0035162,GO:0038156,GO:0042531,GO:0050731

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL3 hsa:3562 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL3 hsa:3562 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL3 hsa:3562 path:hsa04210 Apoptosis - Homo sapiens (human)
IL3 hsa:3562 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL3 hsa:3562 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL3 hsa:3562 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
IL3 hsa:3562 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL3 hsa:3562 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
IL3 hsa:3562 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
IL3 hsa:3562 path:hsa05310 Asthma - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CSF2RB IL3 11698286 12393492 15034038 15549123 15573129 17200410 18633355 22323450 23026134 23046136 23125331 23762788 24778133 26192618 interaction type N/A ACSN
IL3 CD40 15034038 15549123 17200410 23026134 23125331 23762788 24778133 26192618 interaction type N/A ACSN
IL3 CD80 15034038 15549123 17200410 23026134 23125331 23762788 24778133 26192618 interaction type N/A ACSN
IL3 CD86 15034038 15549123 17200410 23026134 23125331 23762788 24778133 26192618 interaction type N/A ACSN
IL3RA IL3 23180781 7957082 physical association saturation binding InnateDB
RUNX1 IL3 20506188 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMARCA4 IL3 20506188 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMARCB1 IL3 20506188 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL3 NFATC1 16498406 23180781 physical association anti tag coimmunoprecipitation InnateDB
POU2F1 IL3 16498406 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL3 IL3RA 1465408 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 IL3 18971253 20019798 8704203 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IL3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 IL3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RUNX1 IL3 15735013 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL3 10453008 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL3 18971253 8035792 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB IL3 10453008 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 IL3 15735013 trascriptional regulation,stimulation inferred by curator TFlink
JUN IL3 7642615 trascriptional regulation,stimulation inferred by curator TFlink
JUNB IL3 8704203 trascriptional regulation,stimulation inferred by curator TFlink
JUND IL3 8704203 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1T1 IL3 15735013 trascriptional regulation,stimulation inferred by curator TFlink
SP1 IL3 8454603 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 IL3 8454603 trascriptional regulation,stimulation inferred by curator TFlink
VEZF1 IL3 8035792 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 IL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A IL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 IL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 IL3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 IL3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000101787 IL3 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 IL3 25416803 28301819 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
HRAS IL3 10677502 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3CA IL3 14525934 25348397 9113989 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCR IL3 25348397 N/A physical interaction ComPPI
IL3RA IL3 14525934 25348397 8649415 9278420 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CSF2RB IL3 14525934 18692472 24234451 25348397 9278420 physical association experimental interaction detection,physical interaction,biochemical,saturation binding,in vitro,in vivo ComPPI,HPRD,IntAct
IL3 IL3 12943658 14525934 N/A experimental interaction detection HPRD
IL3 IL3RA 11700046 1465408 27898060 7957082 8649415 9278420 stimulant N/A OmniPath
RUNX1 IL3 27898060 9036972 stimulant N/A OmniPath

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