Gene Information gene info

  1. Home

GENE：NUMB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NUMB
FullNmae NUMB endocytic adaptor protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8060
EnsembleID ENSG00000133961
Uniprot P49757

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NUMB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NUMB autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NUMB GO:0005515,GO:0005737,GO:0005769,GO:0005886,GO:0005905,GO:0005925,GO:0007409,GO:0008013,GO:0010008,GO:0016323,GO:0021670,GO:0021849,GO:0030136,GO:0030335,GO:0030335,GO:0031410,GO:0034332,GO:0045177,GO:0045294,GO:0045296,GO:0050769,GO:0050769,GO:0098978,GO:0099149,GO:1903077

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NUMB hsa:8650 path:hsa04330 Notch signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SU(H) NUMB 21148185 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
AR NUMB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NUMB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 NUMB 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NUMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000001EB3 NUMB 19524507 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 NUMB 19524507 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 NUMB 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000ED600 NUMB 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000272A3D NUMB 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00001EFBE3 NUMB 24092752 24302991 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000427B68 NUMB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF NUMB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 NUMB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002E177F NUMB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 NUMB 25416803 27521217 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 NUMB 25416803 26849305 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
AAK1 NUMB 22135298 phosphorylation N/A PhosphoSite
LNX2 NUMB 25361965 interaction type N/A PTMCode2
NUMB LNX2 25361965 interaction type N/A PTMCode2
TP53 NUMB 25361965 interaction type N/A PTMCode2
NUMB TP53 25361965 interaction type N/A PTMCode2
NOTCH1 NUMB 25361965 interaction type N/A PTMCode2
NUMB NOTCH1 25361965 interaction type N/A PTMCode2
DPYSL2 NUMB 25361965 interaction type N/A PTMCode2
NUMB DPYSL2 25361965 interaction type N/A PTMCode2
APP NUMB 25361965 interaction type N/A PTMCode2
NUMB APP 25361965 interaction type N/A PTMCode2
NUMB SIAH1 25361965 interaction type N/A PTMCode2
SIAH1 NUMB 25361965 interaction type N/A PTMCode2
NUMB AP2A1 25361965 interaction type N/A PTMCode2
AP2A1 NUMB 25361965 interaction type N/A PTMCode2
NUMB L1CAM 25361965 interaction type N/A PTMCode2
L1CAM NUMB 25361965 interaction type N/A PTMCode2
NUMB EPS15 25361965 interaction type N/A PTMCode2
EPS15 NUMB 25361965 interaction type N/A PTMCode2
NUMB ITCH 25361965 interaction type N/A PTMCode2
ITCH NUMB 25361965 interaction type N/A PTMCode2
NUMB PRKCZ 25361965 interaction type N/A PTMCode2
PRKCZ NUMB 25361965 interaction type N/A PTMCode2
NUMB AP2A2 25361965 interaction type N/A PTMCode2
AP2A2 NUMB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FRS3 NUMB 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
RALBP1 NUMB 23211419 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB5 NUMB 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KBTBD7 NUMB 25348397 N/A physical interaction ComPPI
PRKCA NUMB 14525934 17203073 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NOTCH1 NUMB 12682059 14525934 25348397 8755477 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKCD NUMB 14525934 17203073 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCE NUMB 14525934 17203073 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GLI1 NUMB 25348397 N/A physical interaction ComPPI
SIAH1 NUMB 11752454 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CDH1 NUMB 25348397 N/A physical interaction ComPPI
BTRC NUMB 24234451 24561623 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB3 NUMB 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NUMB L1CAM 12942088 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NUMB AP2A1 23211419 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy,in vivo ComPPI,IntAct
NUMB DPYSL2 11121447 12942088 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NUMB ITCH 12682059 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NUMB EPS15 14525934 23211419 24234451 25348397 9303539 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NUMB LNX1 11782429 14525934 16002321 24234451 25348397 9535908 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NUMB PRKCZ 14525934 17203073 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD
NUMB AP2A2 14525934 17203073 23211419 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
NUMB PRKCB 14525934 17203073 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NUMB PRKCG 14525934 17203073 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NUMB PRKCH 14525934 17203073 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NUMB MDM2 12646252 14525934 18172499 24234451 25348397 9632782 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
NUMB TP53 18172499 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NUMB APP 12011466 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
NUMB EGFR 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
NUMB RPL3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NUMB AP2M1 23211419 24189400 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
NUMB IRS1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
NUMB OLIG1 25348397 N/A physical interaction ComPPI
NUMB MAPK8IP2 25348397 N/A physical interaction ComPPI
NUMB TERF2 25348397 N/A physical interaction ComPPI
NUMB TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NUMB XPO1 25348397 N/A physical interaction ComPPI
NUMB CAPZA2 25348397 N/A physical interaction ComPPI
NUMB CLTB 25348397 N/A physical interaction ComPPI
NUMB CLTC 25348397 N/A physical interaction ComPPI
NUMB DBN1 25348397 N/A physical interaction ComPPI
NUMB GAK 25348397 N/A physical interaction ComPPI
NUMB IGBP1 25348397 N/A physical interaction ComPPI
NUMB ATP6AP2 25348397 N/A physical interaction ComPPI
NUMB KIAA1107 25348397 N/A physical interaction ComPPI
NUMB GTSE1 25348397 N/A physical interaction ComPPI
NUMB ANLN 25348397 N/A physical interaction ComPPI
NUMB CTDSPL 25348397 N/A physical interaction ComPPI
NUMB UNC5CL 25348397 N/A physical interaction ComPPI
NUMB TULP3 25348397 N/A physical interaction ComPPI
NUMB STAMBPL1 25348397 N/A physical interaction ComPPI
NUMB DCAF7 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
NUMB HNRNPL 25348397 N/A physical interaction ComPPI
NUMB CTNNB1 24234451 24561623 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUMB BMP2K 23211419 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NUMB EPS15L1 23211419 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NUMB AP1B1 23211419 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NUMB AP2B1 23211419 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NUMB AP2S1 23211419 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NUMB REPS1 23211419 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
NUMB BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
NUMB OCRL 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NUMB BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NUMB EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NUMB LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NUMB TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ITGB2 NUMB 25348397 N/A in vitro ComPPI
LNX2 NUMB 11782429 11922143 14525934 25348397 25814554 26451611 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
COL10A1 NUMB 25348397 N/A physical interaction ComPPI
DRONC NUMB 25348397 N/A physical interaction ComPPI
NUMB RM62 25348397 N/A two hybrid,physical interaction ComPPI
NUMB KTUB 14605208 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUMB MAD 14605208 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUMB APKC 18854163 24234451 25348397 phosphorylation reaction,association pull down,physical interaction,protein kinase assay ComPPI,IntAct
NUMB N 25348397 N/A physical interaction ComPPI
NUMB AP-2ALPHA 18854163 24234451 25348397 association,physical association experimental interaction detection,pull down,physical interaction ComPPI,IntAct
PRKCZ NUMB 17203073 24234451 phosphorylation reaction protein kinase assay IntAct
NUMB PRKCA 17203073 24234451 phosphorylation reaction protein kinase assay IntAct
NUMB DNAJC5 24234451 29997244 physical association bioluminescence resonance energy transfer IntAct
HSPD1 NUMB 24234451 30021884 physical association cross-linking study IntAct
SELP NUMB 19138666 27898060 N/A N/A OmniPath
NUMB TRPV6 23140583 24704446 27898060 inhibition N/A OmniPath
NUMB ITCH 12682059 18628966 20818436 27898060 stimulant N/A OmniPath
SIAH1 NUMB 11752454 21988832 27898060 inhibition N/A OmniPath
NUMB MDM2 12646252 16678796 18172499 20940030 22337874 23252402 27898060 9632782 inhibition N/A OmniPath
MDM2 NUMB 12646252 16678796 18172499 20940030 22337874 23252402 27898060 9632782 inhibition N/A OmniPath
NUMB TP53 18172499 18492217 22157679 23881403 27898060 stimulant N/A OmniPath
PRKCZ NUMB 17203073 18767875 27898060 N/A N/A OmniPath
NUMB GLI1 20818436 27898060 inhibition N/A OmniPath
NUMB NOTCH1 12682059 15358736 23252402 27898060 8755477 inhibition,stimulant N/A OmniPath
CSNK2A1 NUMB 17609107 27898060 N/A N/A OmniPath
PRKCI NUMB 17609107 27898060 inhibition N/A OmniPath
CAMK1 NUMB 17022975 27898060 inhibition N/A OmniPath
LNX1 NUMB 11782429 14990566 16002321 27898060 9535908 9846878 inhibition N/A OmniPath
MSI1 NUMB 20477901 27898060 inhibition N/A OmniPath
SLC30A9 NUMB 11782429 27898060 inhibition N/A OmniPath
AAK1 NUMB 17609107 18657069 27898060 stimulant N/A OmniPath

Visualization










  Return