Gene Information gene info

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GENE：RRAS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RRAS2
FullNmae RAS related 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17271
EnsembleID ENSG00000133818
Uniprot P62070

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RRAS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RRAS2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RRAS2 GO:0000139,GO:0001649,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005783,GO:0005886,GO:0005886,GO:0005925,GO:0007265,GO:0016020,GO:0019003,GO:0036135,GO:0070062,GO:1900149

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RRAS2 hsa:22800 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04140 Autophagy - animal - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04218 Cellular senescence - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
RRAS2 hsa:22800 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RAF1 RRAS2 10783161 23180781 physical association two hybrid InnateDB
RRAS2 RGL2 23180781 8939933 physical association two hybrid InnateDB
RRAS2 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
RRAS2 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AFDN RRAS2 20005715 interaction type N/A PSP
PIK3R1 RRAS2 20005715 interaction type N/A PSP,SignaLink
RASIP1 RRAS2 20005715 interaction type N/A PSP
RASSF5 RRAS2 20005715 interaction type N/A PSP
TRAF3 RRAS2 20005715 interaction type N/A PSP
AFDN RRAS2 11788587 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR RRAS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RRAS2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RRAS2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RRAS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RRAS2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RRAS2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RRAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BTF3 RRAS2 17312387 trascriptional regulation,stimulation inferred by curator TFlink
BTN3A2 RRAS2 17312387 trascriptional regulation,stimulation inferred by curator TFlink
BTN3A3 RRAS2 17312387 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 RRAS2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000003ABC4 RRAS2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000031BC7D RRAS2 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS000049FAE8 RRAS2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED RRAS2 24391759 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000033EBB8 RRAS2 20371350 21572407 22012620 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000012930C RRAS2 20371350 21572407 22012620 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD02D RRAS2 20371350 21572407 22012620 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000B7E30 RRAS2 20371350 21572407 22012620 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000006F90B RRAS2 20371350 21572407 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000039E1E1 RRAS2 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC RRAS2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C RRAS2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5659 RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004C689A RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000211070 RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 RRAS2 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 RRAS2 22135298 phosphorylation N/A PhosphoSite
MAPK1 RRAS2 22135298 phosphorylation N/A PhosphoSite
RAF1 RRAS2 25361965 interaction type N/A PTMCode2
RRAS2 RAF1 25361965 interaction type N/A PTMCode2
RRAS2 BRAF 25361965 interaction type N/A PTMCode2
BRAF RRAS2 25361965 interaction type N/A PTMCode2
RRAS2 RAP1GAP 25361965 interaction type N/A PTMCode2
RAP1GAP RRAS2 25361965 interaction type N/A PTMCode2
RRAS2 ARAF 25361965 interaction type N/A PTMCode2
ARAF RRAS2 25361965 interaction type N/A PTMCode2
RRAS2 PGGT1B 25361965 interaction type N/A PTMCode2
PGGT1B RRAS2 25361965 interaction type N/A PTMCode2
RRAS2 RASGRF1 25361965 interaction type N/A PTMCode2
RASGRF1 RRAS2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TSNAX RRAS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RABGGTB RRAS2 25348397 N/A physical interaction ComPPI
SMAD4 RRAS2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RASSF5 RRAS2 11857081 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RIN1 RRAS2 11788587 14525934 19060904 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,in vivo,two hybrid ComPPI,HPRD,IntAct
RABAC1 RRAS2 11335720 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SMURF2 RRAS2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3R1 RRAS2 11850823 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ARAF RRAS2 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 RRAS2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PGGT1B RRAS2 14525934 15451670 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ARHGEF2 RRAS2 12384139 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RRAS2 PTPN1 11788587 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RRAS2 RAPGEF1 12384139 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RRAS2 TRAF3 10557073 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RRAS2 RAPGEF3 25348397 N/A in vitro ComPPI
RRAS2 RAPGEF4 12384139 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RRAS2 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RRAS2 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RRAS2 XRCC6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RRAS2 LGALS4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RRAS2 PAWR 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RRAS2 FNTB 14525934 15451670 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RRAS2 AHSG 11788587 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RRAS2 RAF1 10064593 11788587 12620389 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
RRAS2 RALGDS 11788587 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
RRAS2 AFDN 25348397 N/A physical interaction ComPPI
RRAS2 CDK2 25348397 N/A physical interaction ComPPI
RRAS2 PAN2 25348397 N/A physical interaction ComPPI
RRAS2 TRAF2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RRAS2 CREB3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RRAS2 CCDC8 25348397 N/A physical interaction ComPPI
RRAS2 DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRAS2 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRAS2 SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRAS2 LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRAS2 FOXS1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RRAS2 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
RASGRF1 RRAS2 12384139 14525934 N/A experimental interaction detection HPRD
RASIP1 RRAS2 14525934 15031288 N/A two hybrid HPRD
RAF1 RRAS2 10064593 10557073 10783161 11788587 12620389 27898060 N/A N/A OmniPath
RGL2 RRAS2 27898060 8939933 N/A N/A OmniPath

Visualization










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