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GENE：PRPF19

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRPF19
FullNmae pre-mRNA processing factor 19
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17896
EnsembleID ENSG00000110107
Uniprot Q9UMS4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRPF19 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRPF19 GO:0000077,GO:0000209,GO:0000244,GO:0000245,GO:0000398,GO:0000398,GO:0000398,GO:0000398,GO:0000974,GO:0000974,GO:0000974,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0005737,GO:0005811,GO:0005819,GO:0006303,GO:0008104,GO:0008610,GO:0010498,GO:0016020,GO:0016607,GO:0034450,GO:0035861,GO:0042802,GO:0048026,GO:0061630,GO:0061630,GO:0070534,GO:0071006,GO:0071007,GO:0071013

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRPF19 hsa:27339 path:hsa03040 Spliceosome - Homo sapiens (human)
PRPF19 hsa:27339 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EED PRPF19 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 PRPF19 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PRPF19 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PRPF19 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PRPF19 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PRPF19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRPF19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRPF19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PRPF19 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 PRPF19 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000065D58 PRPF19 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 PRPF19 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
KPNA2 PRPF19 25348397 N/A physical interaction ComPPI
SF3A3 PRPF19 25348397 N/A physical interaction ComPPI
BCAS2 PRPF19 22365833 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
LGALS3 PRPF19 25348397 N/A physical interaction ComPPI
SNW1 PRPF19 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GCC1 PRPF19 25348397 N/A physical interaction ComPPI
CDC5L PRPF19 19633697 20467437 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
YJU2 PRPF19 25348397 N/A physical interaction ComPPI
SNRPA PRPF19 25348397 N/A physical interaction ComPPI
DHX15 PRPF19 24234451 24304693 25348397 colocalization cosedimentation through density gradient,physical interaction ComPPI,IntAct
RPN1 PRPF19 25348397 N/A physical interaction ComPPI
CD2BP2 PRPF19 25348397 N/A physical interaction ComPPI
SNRPA1 PRPF19 25348397 N/A physical interaction ComPPI
KPNA1 PRPF19 25348397 N/A physical interaction ComPPI
SNRPD1 PRPF19 25348397 N/A physical interaction ComPPI
VCP PRPF19 25348397 N/A physical interaction ComPPI
LMNA PRPF19 25348397 N/A physical interaction ComPPI
GABARAPL2 PRPF19 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
U2AF1L5 PRPF19 25348397 N/A physical interaction ComPPI
YWHAG PRPF19 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 PRPF19 25348397 N/A physical interaction ComPPI
KEAP1 PRPF19 25348397 N/A physical interaction ComPPI
WDR83 PRPF19 25348397 N/A physical interaction ComPPI
STRN PRPF19 25348397 N/A physical interaction ComPPI
HSP90AB1 PRPF19 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
INO80B PRPF19 25348397 N/A physical interaction ComPPI
FAM167A PRPF19 25348397 N/A physical interaction ComPPI
EGLN3 PRPF19 20599946 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NF2 PRPF19 25348397 N/A physical interaction ComPPI
SF3A2 PRPF19 17332742 24234451 25348397 physical association affinity chromatography technology,physical interaction ComPPI,IntAct
SNRNP70 PRPF19 25348397 N/A physical interaction ComPPI
PPP4C PRPF19 25348397 N/A physical interaction ComPPI
PTPN11 PRPF19 25348397 N/A physical interaction ComPPI
NOTCH1 PRPF19 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
JUN PRPF19 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 PRPF19 25348397 N/A physical interaction ComPPI
RBM39 PRPF19 25348397 N/A physical interaction ComPPI
SF3B1 PRPF19 25348397 N/A physical interaction ComPPI
PSMA3 PRPF19 25348397 N/A physical interaction ComPPI
U2AF2 PRPF19 25348397 N/A physical interaction ComPPI
CUL3 PRPF19 25348397 N/A physical interaction ComPPI
UBC PRPF19 25348397 N/A physical interaction ComPPI
DLD PRPF19 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HSP90AA1 PRPF19 25348397 N/A physical interaction ComPPI
NTRK1 PRPF19 25348397 N/A physical interaction ComPPI
ENO1 PRPF19 25348397 N/A physical interaction ComPPI
VTN PRPF19 25348397 N/A physical interaction ComPPI
YBX1 PRPF19 24234451 25348397 25497084 association anti bait coimmunoprecipitation ComPPI,IntAct
RBM14 PRPF19 25348397 N/A physical interaction ComPPI
RPA1 PRPF19 25348397 N/A physical interaction ComPPI
DNTT PRPF19 12960389 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
USB1 PRPF19 25348397 N/A physical interaction ComPPI
DDX5 PRPF19 25348397 N/A physical interaction ComPPI
PDHA1 PRPF19 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
XAB2 PRPF19 25348397 N/A physical interaction ComPPI
EXOC3 PRPF19 25348397 N/A physical interaction ComPPI
RBM10 PRPF19 22365833 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
RPA2 PRPF19 25348397 N/A physical interaction ComPPI
RPA3 PRPF19 25348397 N/A physical interaction ComPPI
USP4 PRPF19 25348397 N/A physical interaction ComPPI
ZNHIT3 PRPF19 25348397 N/A physical interaction ComPPI
RNF8 PRPF19 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
HUWE1 PRPF19 25348397 N/A physical interaction ComPPI
SRSF1 PRPF19 25348397 N/A physical interaction ComPPI
CSNK2A2 PRPF19 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SMC1A PRPF19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SON PRPF19 25348397 N/A physical interaction ComPPI
CUL1 PRPF19 25348397 N/A physical interaction ComPPI
RNF2 PRPF19 25348397 N/A physical interaction ComPPI
SF3A1 PRPF19 25348397 N/A physical interaction ComPPI
POLR2A PRPF19 25348397 N/A physical interaction ComPPI
GABARAP PRPF19 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPB1 PRPF19 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TUBGCP3 PRPF19 25348397 N/A physical interaction ComPPI
UBE2A PRPF19 25348397 N/A physical interaction ComPPI
SRSF11 PRPF19 25348397 N/A physical interaction ComPPI
EED PRPF19 25348397 N/A physical interaction ComPPI
UTP14A PRPF19 25348397 N/A physical interaction ComPPI
LAMP2 PRPF19 25348397 N/A physical interaction ComPPI
PRKN PRPF19 25348397 N/A physical interaction ComPPI
CUL7 PRPF19 25348397 N/A physical interaction ComPPI
HDAC5 PRPF19 25348397 N/A physical interaction ComPPI
CAND1 PRPF19 25348397 N/A physical interaction ComPPI
PRPF6 PRPF19 25348397 N/A physical interaction ComPPI
PRPS1 PRPF19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2D3 PRPF19 25348397 N/A physical interaction ComPPI
TFIP11 PRPF19 25348397 N/A physical interaction ComPPI
SEC13 PRPF19 25348397 N/A physical interaction ComPPI
SNCA PRPF19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNRPD2 PRPF19 25348397 N/A physical interaction ComPPI
TRIM25 PRPF19 25348397 N/A physical interaction ComPPI
SRP14 PRPF19 25348397 N/A physical interaction ComPPI
PRPF4 PRPF19 25348397 N/A physical interaction ComPPI
SRSF5 PRPF19 25348397 N/A physical interaction ComPPI
ESR1 PRPF19 25348397 N/A physical interaction ComPPI
SNRNP200 PRPF19 25348397 N/A physical interaction ComPPI
BRCA1 PRPF19 25348397 N/A physical interaction ComPPI
STUB1 PRPF19 25348397 N/A physical interaction ComPPI
NDEL1 PRPF19 25348397 N/A physical interaction ComPPI
NUDC PRPF19 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PSMB4 PRPF19 25348397 N/A physical interaction ComPPI
ESS2 PRPF19 25348397 N/A physical interaction ComPPI
SENP6 PRPF19 25348397 N/A physical interaction ComPPI
PPP4R2 PRPF19 24234451 25348397 28330616 association pull down ComPPI,IntAct
TADA2A PRPF19 25348397 N/A physical interaction ComPPI
MAGOH PRPF19 23084401 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLRG1 PRPF19 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SRRM2 PRPF19 25348397 N/A physical interaction ComPPI
RNPS1 PRPF19 25348397 N/A physical interaction ComPPI
EGLN2 PRPF19 25348397 N/A physical interaction ComPPI
TRIM55 PRPF19 25348397 N/A physical interaction ComPPI
RPS10 PRPF19 25348397 N/A physical interaction ComPPI
EFTUD2 PRPF19 25348397 N/A physical interaction ComPPI
IKBKE PRPF19 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CEP250 PRPF19 25348397 N/A physical interaction ComPPI
HNRNPM PRPF19 25348397 N/A physical interaction ComPPI
TARDBP PRPF19 25348397 N/A physical interaction ComPPI
SRRM1 PRPF19 25348397 N/A physical interaction ComPPI
SF3B3 PRPF19 25348397 N/A physical interaction ComPPI
CDC40 PRPF19 22365833 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
RRP1B PRPF19 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF4A3 PRPF19 23084401 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUZ12 PRPF19 25348397 N/A physical interaction ComPPI
PRPF3 PRPF19 25348397 N/A physical interaction ComPPI
TSC22D1 PRPF19 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PRPF19 EXOC7 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRPF19 CTNNBL1 25348397 N/A physical interaction ComPPI
PRPF19 SETMAR 25348397 N/A physical interaction ComPPI
PRPF19 SMARCAD1 25348397 N/A physical interaction ComPPI
PRPF19 PSMA2 25348397 N/A physical interaction ComPPI
PRPF19 HNRNPA1 25348397 N/A physical interaction ComPPI
PRPF19 APEX1 25348397 N/A physical interaction ComPPI
PRPF19 KHDC4 19641227 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRPF19 CWC15 25348397 N/A physical interaction ComPPI
PRPF19 PRPF8 22365833 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PRPF19 SART1 25348397 N/A physical interaction ComPPI
PRPF19 U2AF1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRPF19 SF3B6 25348397 N/A physical interaction ComPPI
PRPF19 RBM25 25348397 N/A physical interaction ComPPI
PRPF19 RPS24 25348397 N/A physical interaction ComPPI
PRPF19 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PRPF19 RBM5 22365833 22569250 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
PRPF19 PRCC 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRPF19 DDX42 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRPF19 HSP90AA2P 25348397 N/A physical interaction ComPPI
PRPF19 UCHL5 25348397 N/A physical interaction ComPPI
PRPF19 GSTK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRPF19 MEPCE 25348397 N/A physical interaction ComPPI
PRPF19 LIN28A 25348397 N/A physical interaction ComPPI
PRPF19 CEP57 25348397 N/A physical interaction ComPPI
PRPF19 CEP76 25348397 N/A physical interaction ComPPI
PRPF19 MOV10 25348397 N/A physical interaction ComPPI
PRPF19 NXF1 25348397 N/A physical interaction ComPPI
PRPF19 OBSL1 25348397 N/A physical interaction ComPPI
PRPF19 KNSTRN 24718257 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRPF19 CWC22 25348397 N/A physical interaction ComPPI
PRPF19 DHX8 25348397 N/A physical interaction ComPPI
PRPF19 LTN1 25348397 N/A physical interaction ComPPI
PRPF19 MTCH1 25348397 N/A physical interaction ComPPI
PRPF19 BUD31 11804584 15303280 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRPF19 CZIB 25348397 N/A physical interaction ComPPI
PRPF19 ISY1 10318896 11018040 11804584 11842115 16357217 17515604 19617314 19704000 20956557 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRPF19 MTHFD1 25348397 N/A physical interaction ComPPI
PRPF19 PDIA5 25348397 N/A physical interaction ComPPI
PRPF19 RNF113B 25348397 N/A physical interaction ComPPI
PRPF19 UBXN1 25348397 N/A physical interaction ComPPI
PRPF19 USP39 25348397 N/A physical interaction ComPPI
PRPF19 AHSA1 25348397 N/A physical interaction ComPPI
PRPF19 USP37 25348397 N/A physical interaction ComPPI
PRPF19 ZDBF2 25348397 N/A physical interaction ComPPI
PRPF19 GPATCH1 25348397 N/A physical interaction ComPPI
PRPF19 CWF19L2 25348397 N/A physical interaction ComPPI
PRPF19 AQR 24234451 24304693 25348397 colocalization cosedimentation through density gradient,physical interaction ComPPI,IntAct
PRPF19 GCFC2 25348397 N/A physical interaction ComPPI
PRPF19 DHX35 25348397 N/A physical interaction ComPPI
PRPF19 CCDC18 25348397 N/A physical interaction ComPPI
PRPF19 CCDC12 25348397 N/A physical interaction ComPPI
PRPF19 CWF19L1 25348397 N/A physical interaction ComPPI
PRPF19 CRNKL1 25348397 N/A physical interaction ComPPI
PRPF19 SYF2 25348397 N/A physical interaction ComPPI
PRPF19 PPIE 25348397 N/A physical interaction ComPPI
PRPF19 RBM22 25348397 N/A physical interaction ComPPI
PRPF19 ZNF830 25348397 N/A physical interaction ComPPI
PRPF19 CYLD 25348397 N/A physical interaction ComPPI
PRPF19 AAR2 25348397 N/A physical interaction ComPPI
PRPF19 EAPP 25348397 N/A physical interaction ComPPI
PRPF19 ECD 25348397 N/A physical interaction ComPPI
PRPF19 SLC7A6OS 25348397 N/A physical interaction ComPPI
PRPF19 TSSC4 25348397 N/A physical interaction ComPPI
PRPF19 ZNHIT2 25348397 N/A physical interaction ComPPI
PRPF19 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRPF19 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRPF19 MTF1 25348397 N/A physical interaction ComPPI
PRPF19 MED29 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRPF19 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRPF19 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
LYAR PRPF19 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SLMAP PRPF19 25348397 N/A physical interaction ComPPI
DDX41 PRPF19 24234451 25348397 25920683 association anti tag coimmunoprecipitation ComPPI,IntAct
FLNA PRPF19 24234451 30021884 physical association cross-linking study IntAct
L1TD1 PRPF19 24234451 25702638 association anti bait coimmunoprecipitation IntAct

Source Target Pmid Interactiontype Methods Database
URS00009B66B5 PRPF19 27087310 direct interaction,inhibition N/A NPInter

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