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GENE：SLC6A4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SLC6A4
FullNmae solute carrier family 6 member 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11050
EnsembleID ENSG00000108576
Uniprot P31645

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SLC6A4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SLC6A4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SLC6A4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SLC6A4 GO:0001666,GO:0005178,GO:0005261,GO:0005326,GO:0005335,GO:0005335,GO:0005335,GO:0005335,GO:0005515,GO:0005886,GO:0005886,GO:0005925,GO:0006836,GO:0007584,GO:0007613,GO:0007623,GO:0008504,GO:0008504,GO:0009410,GO:0009636,GO:0010008,GO:0010628,GO:0012505,GO:0014064,GO:0015297,GO:0015844,GO:0017075,GO:0019811,GO:0021941,GO:0031402,GO:0032227,GO:0032355,GO:0035176,GO:0035725,GO:0042310,GO:0042713,GO:0042734,GO:0042802,GO:0043005,GO:0045121,GO:0045202,GO:0045211,GO:0045665,GO:0045787,GO:0046621,GO:0048484,GO:0048854,GO:0050998,GO:0051015,GO:0051378,GO:0051378,GO:0051610,GO:0051610,GO:0051610,GO:0051610,GO:0051610,GO:0051899,GO:0070527,GO:0071300,GO:0071321,GO:0090067,GO:0099154

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SLC6A4 hsa:6532 path:hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
SLC6A4 hsa:6532 path:hsa04726 Serotonergic synapse - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA1 SLC6A4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SLC6A4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA SLC6A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SLC6A4 15229244 17360901 18971253 21309950 23765727 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SLC6A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SLC6A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SLC6A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SLC6A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SLC6A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SLC6A4 22399227 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SLC6A4 22399227 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A SLC6A4 11483245 trascriptional regulation,stimulation inferred by curator TFlink
YBX1 SLC6A4 15229244 17360901 23765727 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 SLC6A4 N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 SLC6A4 N/A trascriptional regulation,stimulation inferred by curator TFlink
ELK1 SLC6A4 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN SLC6A4 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 SLC6A4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SLC6A4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000075A9CF SLC6A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 SLC6A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 SLC6A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA SLC6A4 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 SLC6A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SLC6A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C SLC6A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000553F51 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002E177F SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 SLC6A4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 SLC6A4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000014F13C SLC6A4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002394F5 SLC6A4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001919B0 SLC6A4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002E728C SLC6A4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA SLC6A4 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CAMK2A SLC6A4 22135298 phosphorylation N/A PhosphoSite
MAPK3 SLC6A4 22135298 phosphorylation N/A PhosphoSite
MAPK14 SLC6A4 22135298 phosphorylation N/A PhosphoSite
PRKG1 SLC6A4 22135298 phosphorylation N/A PhosphoSite
MAPK1 SLC6A4 22135298 phosphorylation N/A PhosphoSite
MAPK9 SLC6A4 22135298 phosphorylation N/A PhosphoSite
PRKCA SLC6A4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HSPA8 SLC6A4 25348397 N/A physical interaction ComPPI
HSP90AB1 SLC6A4 25348397 N/A physical interaction ComPPI
PICK1 SLC6A4 11343649 24234451 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CANX SLC6A4 25348397 N/A physical interaction ComPPI
CALR SLC6A4 10364189 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
STIP1 SLC6A4 25348397 N/A physical interaction ComPPI
HSPA1A SLC6A4 25348397 N/A physical interaction ComPPI
HSPA1B SLC6A4 25348397 N/A physical interaction ComPPI
PTGES3 SLC6A4 25348397 N/A physical interaction ComPPI
STX1A SLC6A4 12175857 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
SNCA SLC6A4 16882008 19429025 25348397 27898060 N/A physical interaction ComPPI,OmniPath
STUB1 SLC6A4 25348397 N/A physical interaction ComPPI
SNCG SLC6A4 25348397 N/A physical interaction ComPPI
SLC6A4 GPM6B 18581270 24234451 25348397 27898060 physical association two hybrid ComPPI,IntAct,OmniPath
YBX1 SLC6A4 14525934 15229244 N/A experimental interaction detection,two hybrid HPRD
PRKG1 SLC6A4 16112691 17310063 17913921 27898060 stimulant N/A OmniPath
PRKCA SLC6A4 24450286 27898060 N/A N/A OmniPath
TTK SLC6A4 17310063 17913921 19270731 20118234 27898060 N/A N/A OmniPath

Visualization










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