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GENE：IRS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRS2
FullNmae insulin receptor substrate 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6126
EnsembleID ENSG00000185950
Uniprot Q9Y4H2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRS2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IRS2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRS2 GO:0002053,GO:0002903,GO:0005068,GO:0005158,GO:0005515,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006006,GO:0007165,GO:0007420,GO:0008284,GO:0008286,GO:0008286,GO:0009749,GO:0010631,GO:0010634,GO:0010748,GO:0010907,GO:0019216,GO:0019903,GO:0019904,GO:0030879,GO:0030890,GO:0032000,GO:0032024,GO:0032869,GO:0033673,GO:0043548,GO:0044342,GO:0045725,GO:0045725,GO:0046326,GO:0055088,GO:0071333,GO:0071889,GO:1904692

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRS2 hsa:8660 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04140 Autophagy - animal - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04931 Insulin resistance - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
IRS2 hsa:8660 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
IRS2 hsa:8660 path:hsa05010 Alzheimer disease - Homo sapiens (human)
IRS2 hsa:8660 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL13 IRS2 12223527 12401408 14610620 14657224 15099563 18250477 18451175 20184663 21097505 26192618 26755705 9535722 interaction type N/A ACSN
IL2RG IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL4 IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IL4R IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
JAK1 IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 29145629 2965306 7512720 7521688 9233603 9834059 interaction type,physical association inferred by curator ACSN,Reactome
JAK2 IRS2 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 9834059 interaction type N/A ACSN
IRS2 GRB2 19109239 26192618 7890616 9535722 interaction type N/A ACSN
BCL9 IRS2 11274345 11955436 11967263 12051714 12417340 15001769 15279786 15337521 16007092 16039586 16510874 17143292 17303408 17439715 17565603 17660363 17936032 18590585 19619488 19623618 19879327 20006983 20144767 20530697 20705860 20920541 21285352 22020335 23296977 23343194 24023259 25730849 26192618 26587781 7542250 7575488 8545107 8666229 interaction type N/A ACSN
JUN IRS2 11274345 11955436 11967263 12051714 12417340 15001769 15279786 15337521 16007092 16039586 16510874 17143292 17303408 17439715 17565603 17660363 17936032 18590585 19619488 19623618 19879327 20006983 20144767 20530697 20705860 20920541 21285352 22020335 23296977 23343194 24023259 25730849 26192618 26587781 7542250 7575488 8545107 8666229 interaction type N/A ACSN
IKBKB IRS2 12351658 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRS2 JAK1 23180781 9233603 physical association anti tag coimmunoprecipitation InnateDB
PIK3R1 IRS2 10194437 10455108 11063744 11147812 11598010 12506011 15149544 24243840 29145629 9334184 physical association inferred by curator Reactome
PIK3CD IRS2 10194437 10455108 11598010 12506011 15149544 29145629 9334184 physical association inferred by curator Reactome
PLCG2 IRS2 15644415 29145629 8034732 physical association inferred by curator Reactome
PLCG1 IRS2 15644415 29145629 8034732 physical association inferred by curator Reactome
STAT5B IRS2 11007921 22509308 29145629 7608147 7744007 8861946 9057652 9587401 9657743 9722506 9837784 9923445 physical association inferred by curator Reactome
STAT5A IRS2 11007921 22509308 29145629 7608147 7744007 8861946 9057652 9587401 9657743 9722506 9837784 9923445 physical association inferred by curator Reactome
SOS1 IRS2 29145629 7739560 8316835 8400282 8530377 8621421 8810325 8816480 9003010 9209406 9832424 9852124 physical association inferred by curator Reactome
VAV1 IRS2 29145629 7539782 8677749 9162069 9209406 physical association inferred by curator Reactome
LYN IRS2 24243840 29145629 physical association inferred by curator Reactome
IRS2 IRS2 10688912 11748924 15316008 17565041 18382766 18516053 24243840 29145629 9405487 physical association inferred by curator Reactome
IL7 IRS2 29145629 9233603 9233603 physical association inferred by curator Reactome
IRS1 IRS2 10688912 11748924 15316008 17565041 18382766 18516053 29145629 9405487 physical association inferred by curator Reactome
KRAS IRS2 24243840 29145629 enzymatic reaction inferred by curator Reactome
HRAS IRS2 24243840 29145629 enzymatic reaction inferred by curator Reactome
NRAS IRS2 24243840 29145629 enzymatic reaction inferred by curator Reactome
MAPK3 IRS2 29145629 7739560 8816480 enzymatic reaction inferred by curator Reactome
INSR IRS2 12101187 18988627 23331499 8626379 8662806 9195949 stimulation N/A SignaLink,SignaLink
IGF1R IRS2 10471495 23331499 stimulation N/A SignaLink
IRS2 PIK3CG 11943559 23331499 stimulation N/A SignaLink
PTPRF IRS2 15588985 23331499 8732688 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
IRS2 PIK3CD 20005715 interaction type N/A PSP,SignaLink
IRS2 PIK3R2 20005715 interaction type N/A PSP
IRS2 JAK2 20005715 interaction type N/A PSP,SignaLink
IRS2 NTRK1 11147812 18988627 20005715 interaction type N/A PSP,SignaLink
IRS2 INSR 20005715 interaction type N/A PSP
IRS2 IGF1R 18988627 20005715 8662806 9852124 interaction type N/A PSP,SignaLink
IRS2 PTPRF 20005715 interaction type N/A PSP,SignaLink
IRS2 ATP2A2 20005715 interaction type N/A PSP
IRS2 PLCG1 18988627 20005715 21071413 9535722 interaction type N/A PSP,SignaLink
IRS2 JAK1 18988627 20005715 7499365 interaction type N/A PSP,SignaLink
IRS2 PTPN6 20005715 interaction type N/A PSP
IRS2 TYK2 18988627 20005715 8550573 interaction type N/A PSP,SignaLink
IRS2 MPL 20005715 interaction type N/A PSP,SignaLink
IRS2 PIK3CA 20005715 interaction type N/A PSP
IRS2 JAK3 18988627 20005715 7499365 interaction type N/A PSP,SignaLink
IRS2 PTPN11 20005715 interaction type N/A PSP
IRS2 PIK3R3 20005715 interaction type N/A PSP
IRS2 ATP2A2 20005715 20005715 N/A N/A SignaLink
IRS2 INSR 20005715 20005715 21071413 8626379 N/A N/A SignaLink
IRS2 PIK3CA 20005715 20005715 N/A N/A SignaLink
IRS2 PIK3R2 10594015 18988627 20005715 20005715 9651378 N/A N/A SignaLink
IRS2 PIK3R3 10417350 18988627 20005715 20005715 N/A N/A SignaLink
IRS2 PTPN11 18988627 20005715 20005715 8910607 N/A N/A SignaLink
IRS2 PTPN6 12198247 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR IRS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 IRS2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 IRS2 19755487 19875459 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ZNF148 IRS2 19875459 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
FOXP3 IRS2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IRS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DLX5 IRS2 21045156 trascriptional regulation,stimulation inferred by curator TFlink
EIF2AK2 IRS2 20685959 trascriptional regulation,stimulation inferred by curator TFlink
FOXO1 IRS2 20685959 trascriptional regulation,stimulation inferred by curator TFlink
NFIC IRS2 19755487 trascriptional regulation,stimulation inferred by curator TFlink
PGR IRS2 14534541 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 IRS2 19755487 19875459 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 IRS2 15881188 16091421 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 IRS2 22431718 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000CBE63 IRS2 23547260 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 IRS2 22431718 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000CBE63 IRS2 23547260 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS00001EFEC1 IRS2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000122ED0 IRS2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE IRS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 IRS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 IRS2 23622248 24810113 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clash,miRNA interference luciferase reporter assay TarBase
URS000009C45F IRS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004F859B IRS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 IRS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C IRS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B IRS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC IRS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 IRS2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 IRS2 25416803 28123847 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 IRS2 22135298 phosphorylation N/A PhosphoSite
PIM1 IRS2 22135298 phosphorylation N/A PhosphoSite
IRS2 PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD IRS2 25361965 interaction type N/A PTMCode2
IRS2 JAK2 25361965 interaction type N/A PTMCode2
JAK2 IRS2 25361965 interaction type N/A PTMCode2
IRS2 JAK3 25361965 interaction type N/A PTMCode2
JAK3 IRS2 25361965 interaction type N/A PTMCode2
IRS2 SHC1 25361965 interaction type N/A PTMCode2
SHC1 IRS2 25361965 interaction type N/A PTMCode2
FES IRS2 25361965 interaction type N/A PTMCode2
IRS2 FES 25361965 interaction type N/A PTMCode2
PIK3CA IRS2 25361965 interaction type N/A PTMCode2
IRS2 PIK3CA 25361965 interaction type N/A PTMCode2
TYK2 IRS2 25361965 interaction type N/A PTMCode2
IRS2 TYK2 25361965 interaction type N/A PTMCode2
BCL2L1 IRS2 25361965 interaction type N/A PTMCode2
IRS2 BCL2L1 25361965 interaction type N/A PTMCode2
IL4R IRS2 25361965 interaction type N/A PTMCode2
IRS2 IL4R 25361965 interaction type N/A PTMCode2
IGF1R IRS2 25361965 interaction type N/A PTMCode2
IRS2 IGF1R 25361965 interaction type N/A PTMCode2
JAK1 IRS2 25361965 interaction type N/A PTMCode2
IRS2 JAK1 25361965 interaction type N/A PTMCode2
EPOR IRS2 25361965 interaction type N/A PTMCode2
IRS2 EPOR 25361965 interaction type N/A PTMCode2
NCL IRS2 25361965 interaction type N/A PTMCode2
IRS2 NCL 25361965 interaction type N/A PTMCode2
YWHAB IRS2 25361965 interaction type N/A PTMCode2
IRS2 YWHAB 25361965 interaction type N/A PTMCode2
IRS1 IRS2 25361965 interaction type N/A PTMCode2
IRS2 IRS1 25361965 interaction type N/A PTMCode2
GRB2 IRS2 25361965 interaction type N/A PTMCode2
IRS2 GRB2 25361965 interaction type N/A PTMCode2
MPL IRS2 25361965 interaction type N/A PTMCode2
IRS2 MPL 25361965 interaction type N/A PTMCode2
CRK IRS2 25361965 interaction type N/A PTMCode2
IRS2 CRK 25361965 interaction type N/A PTMCode2
UBTF IRS2 25361965 interaction type N/A PTMCode2
IRS2 UBTF 25361965 interaction type N/A PTMCode2
PIK3R1 IRS2 25361965 interaction type N/A PTMCode2
IRS2 PIK3R1 25361965 interaction type N/A PTMCode2
SOCS3 IRS2 25361965 interaction type N/A PTMCode2
IRS2 SOCS3 25361965 interaction type N/A PTMCode2
SOCS6 IRS2 25361965 interaction type N/A PTMCode2
IRS2 SOCS6 25361965 interaction type N/A PTMCode2
INSR IRS2 25361965 interaction type N/A PTMCode2
IRS2 INSR 25361965 interaction type N/A PTMCode2
PIK3R2 IRS2 25361965 interaction type N/A PTMCode2
IRS2 PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 IRS2 10594015 14525934 25348397 9651378 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SOCS3 IRS2 14525934 15514089 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 IRS2 14525934 25348397 8550573 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
YWHAG IRS2 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PTPN6 IRS2 12198247 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CRK IRS2 14525934 25348397 8621590 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCL2L1 IRS2 10679027 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EGLN3 IRS2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SOCS1 IRS2 12228220 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIK3R1 IRS2 12107746 14525934 21241768 23617393 24234451 25348397 26496610 9852124 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PTPN11 IRS2 14525934 25348397 8910607 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRB10 IRS2 25348397 N/A physical interaction ComPPI
SHC1 IRS2 11505033 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRB2 IRS2 14525934 21706016 24234451 25348397 7559579 9852124 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
USP7 IRS2 25348397 N/A physical interaction ComPPI
YWHAB IRS2 14525934 15324660 17353931 24234451 24255178 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
YWHAZ IRS2 14525934 15161933 24234451 25348397 26496610 9312143 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
FES IRS2 10856136 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
UBTF IRS2 12554758 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS2 PTPRF 14525934 15588985 25348397 8732688 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRS2 ATP2A1 14525934 25348397 9295312 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRS2 JAK3 14525934 25348397 7499365 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRS2 YWHAE 14525934 24234451 25348397 9312143 association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
IRS2 SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRS2 JAK2 12960006 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRS2 ATP2A2 14525934 25348397 9295312 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRS2 MPL 11054408 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
IRS2 PIK3CA 14525934 25348397 9113989 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IRS2 PIK3R3 10417350 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRS2 SOCS7 12052866 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRS2 NTRK1 11147812 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
IRS2 EPOR 14525934 25348397 9334184 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS2 INSR 14525934 24234451 25348397 8626379 8662806 9195949 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
IRS2 IL4R 14525934 25348397 8954948 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRS2 JAK1 14525934 25348397 7499365 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS2 SFN 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
IRS2 BCL2 25348397 N/A physical interaction ComPPI
IRS2 NISCH 25348397 N/A physical interaction ComPPI
IRS2 PLCG1 14525934 22974441 25348397 27898060 9535722 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
IRS2 IRS1 25348397 N/A physical interaction ComPPI
IRS2 ESR1 25348397 N/A physical interaction ComPPI
IRS2 ELAVL1 25348397 N/A physical interaction ComPPI
IRS2 RPTOR 25348397 N/A physical interaction ComPPI
IRS2 EGFR 25348397 N/A physical interaction ComPPI
IRS2 COPS2 25348397 N/A physical interaction ComPPI
IRS2 DVL2 25348397 N/A physical interaction ComPPI
IRS2 SIRT1 17901049 21241768 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IRS2 FBXW11 25348397 N/A physical interaction ComPPI
IRS2 SRPK2 25348397 N/A physical interaction ComPPI
IRS2 XPO1 25348397 N/A physical interaction ComPPI
IRS2 YWHAH 17979178 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
IRS2 NETO2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRS2 NEDD4 25348397 N/A physical interaction ComPPI
IRS2 EPN1 25348397 N/A physical interaction ComPPI
IRS2 USP15 25348397 N/A physical interaction ComPPI
IRS2 MTOR 25348397 N/A physical interaction ComPPI
IRS2 RPS6KB1 25348397 N/A physical interaction ComPPI
YWHAQ IRS2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IGF1R IRS2 14525934 24234451 25348397 8662806 9852124 physical association two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
MRPL1 IRS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXO3 IRS2 24234451 27451907 association chromatin immunoprecipitation assay IntAct
NTRK2 IRS2 27898060 9374521 stimulant N/A OmniPath
PTPRF IRS2 15588985 27898060 8732688 inhibition,stimulant N/A OmniPath
IGF1R IRS2 10471495 27898060 8662806 9852124 stimulant N/A OmniPath
MAPK3 IRS2 12351658 15364919 27898060 N/A N/A OmniPath
JAK1 IRS2 11591769 27898060 7499365 9233603 stimulant N/A OmniPath
IRS2 JAK1 27898060 7499365 9233603 N/A N/A OmniPath
IRS2 PIK3CA 12933652 22810696 25879670 27898060 9113989 9374521 stimulant N/A OmniPath
INSR IRS2 11584304 12101187 18083107 19534553 19901323 27898060 7526222 7537849 7675087 8626379 8626723 8662806 9195949 stimulant N/A OmniPath
IL4R IRS2 12704343 27898060 8954948 stimulant N/A OmniPath
IKBKB IRS2 12351658 27898060 inhibition N/A OmniPath
IRS2 PIK3CG 11943559 12850284 27898060 stimulant N/A OmniPath

Visualization










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