GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
MT1X
FullNmae
metallothionein 1X
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:7405
EnsembleID
ENSG00000187193
Uniprot
P80297
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
MT1X
pyroptosis
38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
MT1X
cuproptosis
38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
MT1X
cuproptosis
38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes.
63 cuproptosis-related genes
MT1X
cuproptosis
35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION).
Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.15 database.
MT1X
cuproptosis
36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1.
Genes of iron-sulfur cluster related proteins
MT1X
cuproptosis
36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13)
43 cuproptosis-related genes in the study
MT1X
autosis
38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
Go Annotation:
GeneSymbol
Go id
MT1X
GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0006882,GO:0008270,GO:0010038,GO:0010273,GO:0036018,GO:0045926,GO:0046872,GO:0071276,GO:0071276,GO:0071280,GO:0071294,GO:0071294
KEGG Annotation:
GeneSymbol
GeneID
Pathway
Pathway Name
MT1X
hsa:4501 path:hsa04978 Mineral absorption - Homo sapiens (human)
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
ETS1
MT1X
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
YBX1
MT1X
19151767
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
SMARCA4
MT1X
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
MT1X
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F1
MT1X
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
EGR1
MT1X
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
MITF
MT1X
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS00000B59A2
MT1X
19074876
25416803
mrna cleavage,inhibition
array technology
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
ELAVL1
MT1X
25348397
N/A
physical interaction
ComPPI
TERF1
MT1X
21044950
24234451
25348397
physical association
physical interaction,bimolecular fluorescence complementation
ComPPI,IntAct
POT1
MT1X
21044950
24234451
25348397
physical association
physical interaction,bimolecular fluorescence complementation
ComPPI,IntAct
TERF2IP
MT1X
21044950
24234451
25348397
physical association
pull down,physical interaction,bimolecular fluorescence complementation
ComPPI,IntAct
Source
Target
Pmid
Interactiontype
Methods
Database
URS00008B430A
MT1X
27087310
direct interaction,inhibition
N/A
NPInter
Visualization
