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GENE：RALGDS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RALGDS
FullNmae ral guanine nucleotide dissociation stimulator
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9842
EnsembleID ENSG00000160271
Uniprot Q12967

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RALGDS autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RALGDS GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005829,GO:0005886,GO:0005903,GO:0007265,GO:0030695,GO:0030695,GO:0043547

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RALGDS hsa:5900 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RALGDS hsa:5900 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
RALGDS hsa:5900 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
RALGDS hsa:5900 path:hsa05200 Pathways in cancer - Homo sapiens (human)
RALGDS hsa:5900 path:hsa05210 Colorectal cancer - Homo sapiens (human)
RALGDS hsa:5900 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
RALGDS hsa:5900 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS RALGDS 10545207 10783161 10922060 23180781 9150145 physical association two hybrid,gst pull down InnateDB
RALGDS RAP1A 10922060 23180781 physical association two hybrid InnateDB
KRAS RALGDS 10783161 23180781 physical association two hybrid InnateDB
RALGDS RIT1 10545207 23180781 physical association two hybrid InnateDB
RIT2 RALGDS 10545207 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR RALGDS 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RALGDS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RALGDS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RALGDS 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C RALGDS 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RALGDS 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 RALGDS 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 RALGDS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 RALGDS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB RALGDS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000285DCB RALGDS 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC42 RALGDS 23175184 24234451 25348397 association pull down ComPPI,IntAct
KRAS RALGDS 14525934 21988832 24234451 25348397 7809086 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
RAP2B RALGDS 10085114 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
RIN1 RALGDS 25348397 N/A physical interaction ComPPI
HRAS RALGDS 14525934 20936779 24234451 24441586 25241761 25348397 7972015 9038168 physical association experimental interaction detection,nuclear magnetic resonance,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
KDR RALGDS 23175184 24234451 25348397 association pull down ComPPI,IntAct
RRAS RALGDS 14525934 25348397 7809086 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
MAPK3 RALGDS 14525934 24234451 25241761 25348397 9155018 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
RRAS2 RALGDS 11788587 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
MRAS RALGDS 10498616 14525934 25348397 27898060 9400994 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
CDH1 RALGDS 23175184 24234451 25348397 association pull down ComPPI,IntAct
CASP8 RALGDS 25348397 N/A physical interaction ComPPI
FADD RALGDS 25348397 N/A physical interaction ComPPI
RAP1A RALGDS 10085114 14525934 23236378 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
RAP1B RALGDS 21988832 22705156 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
RAP2A RALGDS 10085114 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
ARRB1 RALGDS 12105416 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
RIT1 RALGDS 10545207 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ARRB2 RALGDS 12105416 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
RAF1 RALGDS 19075231 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
CTNNB1 RALGDS 23175184 24234451 25348397 association pull down ComPPI,IntAct
PDK1 RALGDS 25348397 N/A physical interaction ComPPI
SNCA RALGDS 25348397 N/A physical interaction ComPPI
TRIM25 RALGDS 25348397 N/A physical interaction ComPPI
LRPAP1 RALGDS 25348397 N/A physical interaction ComPPI
RAPGEF2 RALGDS 25348397 N/A physical interaction ComPPI
RALGDS CNKSR1 25348397 N/A physical interaction ComPPI
RALGDS CD68 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PDPK1 RALGDS 11889038 14525934 N/A experimental interaction detection HPRD
RIT2 RALGDS 10545207 14525934 N/A two hybrid HPRD
RAP1GAP RALGDS 12464615 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
NF2 RALGDS 14525934 16007223 N/A experimental interaction detection,two hybrid HPRD
CC2D2B RALGDS 24234451 30021884 physical association cross-linking study IntAct
HRAS RALGDS 10545207 10783161 10922060 11786539 15031288 20936779 24441586 25241761 27898060 7809086 7972015 9038168 9150145 9154803 stimulant N/A OmniPath
RALGDS RALA 20478380 27898060 8094051 stimulant N/A OmniPath
RALGDS RIN1 10545207 27898060 stimulant N/A OmniPath
NRAS RALGDS 27898060 7809086 stimulant N/A OmniPath
RAP1A RALGDS 10085114 10922060 11786539 23236378 27898060 inhibition N/A OmniPath
KRAS RALGDS 10783161 21988832 27898060 7809086 stimulant N/A OmniPath
RAP2A RALGDS 10085114 11786539 27898060 stimulant N/A OmniPath
RALGDS RIT1 10545207 27898060 stimulant N/A OmniPath

Visualization










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