GENE：SOS2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SOS2 |
| FullNmae | SOS Ras/Rho guanine nucleotide exchange factor 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11188 |
| EnsembleID | ENSG00000100485 |
| Uniprot | Q07890 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SOS2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SOS2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SOS2 | GO:0001782,GO:0005085,GO:0005515,GO:0005829,GO:0005886,GO:0007265,GO:0008286,GO:0033081,GO:0042129,GO:0043547,GO:0046982,GO:0051057,GO:2000973 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SOS2 | hsa:6655 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04540 | Gap junction - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05034 | Alcoholism - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05214 | Glioma - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
| SOS2 | hsa:6655 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SOS2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | SOS2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | SOS2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SOS2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SOS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SOS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SOS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SOS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | SOS2 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001DE669 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000044FD7 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000284586 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000083D87 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000C73C | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000521626 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BBF48 | SOS2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SOS2 | NCK2 | 25361965 | interaction type | N/A | PTMCode2 |
| NCK2 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | CSF1R | 25361965 | interaction type | N/A | PTMCode2 |
| CSF1R | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | GAB1 | 25361965 | interaction type | N/A | PTMCode2 |
| GAB1 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | PIK3R1 | 25361965 | interaction type | N/A | PTMCode2 |
| PIK3R1 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | NCK1 | 25361965 | interaction type | N/A | PTMCode2 |
| NCK1 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | HRAS | 25361965 | interaction type | N/A | PTMCode2 |
| HRAS | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | GRAP2 | 25361965 | interaction type | N/A | PTMCode2 |
| GRAP2 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | CRKL | 25361965 | interaction type | N/A | PTMCode2 |
| CRKL | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | ABL1 | 25361965 | interaction type | N/A | PTMCode2 |
| ABL1 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | ABI1 | 25361965 | interaction type | N/A | PTMCode2 |
| ABI1 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS2 | SHC1 | 25361965 | interaction type | N/A | PTMCode2 |
| SHC1 | SOS2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PACSIN3 | SOS2 | 14525934 14679214 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo | ComPPI,HPRD,IntAct |
| CRK | SOS2 | 17474147 19380743 24234451 25348397 | association,physical association | peptide array,physical interaction,tandem affinity purification | ComPPI,IntAct |
| HRAS | SOS2 | 12628188 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CD2AP | SOS2 | 14525934 14679214 24234451 25348397 | physical association | experimental interaction detection,pull down,in vitro | ComPPI,HPRD,IntAct |
| PIK3R1 | SOS2 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| SRC | SOS2 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| CRKL | SOS2 | 14525934 25348397 8943292 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| GRAP2 | SOS2 | 10820259 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| SHC1 | SOS2 | 10675333 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| NCK1 | SOS2 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| GRB2 | SOS2 | 10940929 14525934 14679214 17474147 20936779 21706016 21988832 24234451 25348397 7629138 | association,physical association | anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,peptide array,pull down,physical interaction,two hybrid pooling approach,in vivo | ComPPI,HPRD,IntAct |
| NTRK1 | SOS2 | 25348397 | N/A | physical interaction | ComPPI |
| SOS2 | ABI1 | 11003655 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| SOS2 | SNX9 | 14525934 14679214 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo | ComPPI,HPRD,IntAct |
| SOS2 | SNX18 | 14525934 14679214 24234451 25348397 | physical association | experimental interaction detection,pull down,in vitro | ComPPI,HPRD,IntAct |
| SOS2 | SH3D19 | 14525934 14551139 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| SOS2 | EGFR | 10675333 14525934 24234451 24658140 25348397 | physical association | experimental interaction detection,ubiquitin reconstruction,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| SOS2 | LOX | 24234451 25118846 25348397 | physical association | two hybrid | ComPPI,IntAct |
| SOS2 | PLCG1 | 10940929 14525934 17474147 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,fluorescence technology,peptide array,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| SOS2 | ESR1 | 25348397 | N/A | physical interaction | ComPPI |
| SOS2 | ITSN2 | 25348397 | N/A | physical interaction | ComPPI |
| SOS2 | LRRK1 | 25348397 | N/A | physical interaction | ComPPI |
| SOS2 | BIN1 | 25348397 | N/A | physical interaction | ComPPI |
| SOS2 | HNRNPL | 25348397 | N/A | physical interaction | ComPPI |
| SOS2 | ABL1 | 14525934 14679214 17474147 24234451 25348397 | physical association | experimental interaction detection,peptide array | ComPPI,HPRD,IntAct |
| SOS2 | FYN | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| SOS2 | RXRB | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| SOS2 | ABI2 | 14504388 27898060 | N/A | N/A | OmniPath |
| PLCG1 | SOS2 | 10940929 17474147 27898060 | N/A | N/A | OmniPath |
| SOS2 | PLCG1 | 10940929 17474147 27898060 | N/A | N/A | OmniPath |
| SOS2 | HRAS | 12628188 21779497 27898060 | stimulant | N/A | OmniPath |
| GRB2 | SOS2 | 10940929 14679214 17474147 19380743 20936779 21706016 21779497 21988832 27898060 7629138 9199344 | stimulant | N/A | OmniPath |
| SOS2 | GRB2 | 10940929 14679214 17474147 19380743 20936779 21706016 21988832 27898060 7629138 9199344 | N/A | N/A | OmniPath |
| SOS2 | KRAS | 21779497 27898060 | stimulant | N/A | OmniPath |