GENE：EZH1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EZH1 |
| FullNmae | enhancer of zeste 1 polycomb repressive complex 2 subunit |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3526 |
| EnsembleID | ENSG00000108799 |
| Uniprot | Q92800 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EZH1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EZH1 | GO:0000122,GO:0000781,GO:0000792,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0009653,GO:0021766,GO:0031507,GO:0031507,GO:0031509,GO:0032259,GO:0035098,GO:0035098,GO:0042393,GO:0045944,GO:0046976,GO:0140951 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EZH1 | hsa:2145 | path:hsa00310 | Lysine degradation - Homo sapiens (human) |
| EZH1 | hsa:2145 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| EZH1 | hsa:2145 | path:hsa03083 | Polycomb repressive complex - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | EZH1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | EZH1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | EZH1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | EZH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002C0FCB | EZH1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000DDD35 | EZH1 | 20371350 22473208 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00001012BC | EZH1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D5391 | EZH1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000134ADC | EZH1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000171CD1 | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000338542 | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | EZH1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F6 | EZH1 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| EZH2 | EZH1 | 25348397 | N/A | physical interaction | ComPPI |
| RBBP4 | EZH1 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| GATA4 | EZH1 | 25348397 | N/A | physical interaction | ComPPI |
| EED | EZH1 | 14525934 19026780 19026781 24234451 25348397 27705803 27898060 9566901 9584197 | association | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid | ComPPI,HPRD,IntAct,OmniPath |
| ZMYND11 | EZH1 | 14525934 16565076 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| EZH1 | SUZ12 | 20075857 24234451 25348397 27705803 | association | anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| EZH1 | JARID2 | 24234451 25348397 27705803 | association | anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| EZH1 | PHF1 | 24234451 25348397 27705803 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| EZH1 | PHF19 | 24234451 25348397 27705803 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| EZH1 | AEBP2 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| EZH1 | LCOR | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| EZH1 | MTF2 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| EZH1 | RBBP7 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| BLVRA | EZH1 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |