GENE：ATP1A2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATP1A2 |
| FullNmae | ATPase Na+/K+ transporting subunit alpha 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:800 |
| EnsembleID | ENSG00000018625 |
| Uniprot | P50993 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATP1A2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATP1A2 | GO:0001504,GO:0001662,GO:0002026,GO:0002087,GO:0005391,GO:0005391,GO:0005391,GO:0005391,GO:0005391,GO:0005496,GO:0005515,GO:0005524,GO:0005737,GO:0005768,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005890,GO:0005890,GO:0005890,GO:0005890,GO:0005890,GO:0005901,GO:0006813,GO:0006814,GO:0006883,GO:0006883,GO:0006937,GO:0006940,GO:0006942,GO:0008217,GO:0008344,GO:0008542,GO:0010248,GO:0010881,GO:0010996,GO:0014704,GO:0016020,GO:0016020,GO:0016791,GO:0016887,GO:0019229,GO:0019829,GO:0019829,GO:0021764,GO:0021989,GO:0030007,GO:0030007,GO:0030007,GO:0030315,GO:0030955,GO:0031090,GO:0031402,GO:0035094,GO:0035641,GO:0035725,GO:0036376,GO:0036376,GO:0040011,GO:0042995,GO:0042995,GO:0043025,GO:0043197,GO:0045822,GO:0045823,GO:0045988,GO:0046034,GO:0046982,GO:0051087,GO:0051481,GO:0051946,GO:0051966,GO:0055119,GO:0060048,GO:0071260,GO:0071383,GO:0071805,GO:0086004,GO:0086009,GO:0086012,GO:0086064,GO:0098655,GO:0098655,GO:0150104,GO:1902600,GO:1903170,GO:1903280,GO:1903416,GO:1903416,GO:1903561,GO:1990239,GO:1990573,GO:1990573,GO:1990573 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ATP1A2 | hsa:477 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04911 | Insulin secretion - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04964 | Proximal tubule bicarbonate reclamation - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04970 | Salivary secretion - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04976 | Bile secretion - Homo sapiens (human) |
| ATP1A2 | hsa:477 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ATP1A2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| MYC | ATP1A2 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | ATP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ATP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ATP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ATP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ATP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | ATP1A2 | 19296470 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00003380CC | ATP1A2 | 19296470 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000016D2D4 | ATP1A2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001A405B | ATP1A2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000486E0B | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047A67D | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F4AC3 | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5BAA | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E226A | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000475586 | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020579D | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005651EE | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002D349B | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000913AC | ATP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| H4C1 | ATP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | ATP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| VDAC1 | ATP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| RAB1A | ATP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| CLTC | ATP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| VDAC2 | ATP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| TPT1 | ATP1A2 | 14525934 15383549 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| ATP1A2 | FBXO25 | 25348397 | N/A | physical interaction | ComPPI |
| ATP1A2 | ZNRF2 | 25348397 | N/A | physical interaction | ComPPI |
| ATP1A2 | CAND1 | 25348397 | N/A | physical interaction | ComPPI |
| ATP1A2 | CCT7 | 25348397 | N/A | physical interaction | ComPPI |
| ATP1A2 | SCLT1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| ATP1A2 | GABARAP | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ATP1A2 | IFIT3 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| ATP1A2 | DST | 24234451 30021884 | physical association | cross-linking study | IntAct |