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GENE：GABBR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GABBR1
FullNmae gamma-aminobutyric acid type B receptor subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4070
EnsembleID ENSG00000204681
Uniprot Q9UBS5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GABBR1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GABBR1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GABBR1 GO:0001649,GO:0004965,GO:0004965,GO:0005515,GO:0005615,GO:0005789,GO:0005886,GO:0005886,GO:0007193,GO:0007214,GO:0007214,GO:0008021,GO:0008285,GO:0014049,GO:0014053,GO:0030673,GO:0031966,GO:0032811,GO:0033602,GO:0035094,GO:0038039,GO:0038039,GO:0042734,GO:0043025,GO:0043197,GO:0043198,GO:0045211,GO:0045471,GO:0046982,GO:0050805,GO:0051932,GO:0060078,GO:0060124,GO:0098685,GO:0098978,GO:0098982,GO:0099505,GO:0099579,GO:0150047,GO:0150099,GO:1902712,GO:1990430

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GABBR1 hsa:2550 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
GABBR1 hsa:2550 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
GABBR1 hsa:2550 path:hsa04727 GABAergic synapse - Homo sapiens (human)
GABBR1 hsa:2550 path:hsa04742 Taste transduction - Homo sapiens (human)
GABBR1 hsa:2550 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
GABBR1 hsa:2550 path:hsa04929 GnRH secretion - Homo sapiens (human)
GABBR1 hsa:2550 path:hsa05032 Morphine addiction - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 GABBR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 GABBR1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 GABBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GABBR1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 GABBR1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000042E1F GABBR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 GABBR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 GABBR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 GABBR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 GABBR1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA GABBR1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ATF4 GABBR1 25361965 interaction type N/A PTMCode2
GABBR1 ATF4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ATF4 GABBR1 25348397 N/A physical interaction ComPPI
CRK GABBR1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
PIK3R1 GABBR1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NCK1 GABBR1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 GABBR1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
YWHAZ GABBR1 11178869 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
RGS4 GABBR1 25348397 N/A physical interaction ComPPI
NSF GABBR1 14525934 16724110 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,imaging technique,in vivo ComPPI,HPRD,IntAct
FYN GABBR1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
KCNJ6 GABBR1 25348397 N/A physical interaction ComPPI
GABBR1 ATF5 11087824 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GABBR1 GABBR2 10075644 14525934 16724110 24234451 24658140 25348397 9872316 physical association anti tag coimmunoprecipitation,two hybrid,cross-linking study,experimental interaction detection,molecular sieving,ubiquitin reconstruction,x-ray crystallography,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
GABBR1 JAKMIP1 14525934 14718537 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
GABBR1 CHFR 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GABBR1 GNAO1 25348397 N/A physical interaction ComPPI
GABBR1 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GABBR1 MAX 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
GABBR1 USP14 25348397 N/A physical interaction ComPPI
GABBR1 DDIT3 25348397 N/A physical interaction ComPPI
GABBR1 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GABBR1 GPR37 24234451 28298427 physical association anti bait coimmunoprecipitation,ubiquitin reconstruction IntAct
BDKRB1 GABBR1 24234451 28298427 physical association ubiquitin reconstruction IntAct
CCR8 GABBR1 24234451 28298427 physical association ubiquitin reconstruction IntAct
GABBR1 DRD2 24234451 28298427 physical association ubiquitin reconstruction IntAct
SMO GABBR1 24234451 28298427 physical association ubiquitin reconstruction IntAct
CAMK2A GABBR1 20643921 27898060 inhibition N/A OmniPath
GABBR1 GNAO1 12917685 27898060 stimulant N/A OmniPath
GABBR2 GABBR1 10075644 10917635 16724110 24305054 24658140 26817839 27898060 9872316 N/A N/A OmniPath
GABBR1 GABBR2 10075644 10917635 16724110 24305054 24658140 26817839 27898060 9872316 N/A N/A OmniPath

Visualization










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