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GENE：M6PR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol M6PR
FullNmae mannose-6-phosphate receptor, cation dependent
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6752
EnsembleID ENSG00000003056
Uniprot P20645

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
M6PR lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
M6PR lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
M6PR autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
M6PR GO:0004888,GO:0005515,GO:0005765,GO:0005768,GO:0005770,GO:0005802,GO:0005886,GO:0006622,GO:0006898,GO:0007041,GO:0008333,GO:0016020,GO:0019904,GO:0030133,GO:0030669,GO:0032588,GO:0033299,GO:0048471,GO:1905394

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
M6PR hsa:4074 path:hsa04142 Lysosome - Homo sapiens (human)
M6PR hsa:4074 path:hsa04145 Phagosome - Homo sapiens (human)
M6PR hsa:4074 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
M6PR GZMB 11081635 20634814 26192618 8432729 interaction type N/A ACSN
M6PR GZMA 11081635 20634814 26192618 8432729 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 M6PR 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 M6PR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 M6PR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 M6PR 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA M6PR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 M6PR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF M6PR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 M6PR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 M6PR N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC M6PR N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 M6PR 21282569 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 M6PR 21282569 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005651EE M6PR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D M6PR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000044FD7 M6PR 24039954 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002FB065 M6PR 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 M6PR 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 M6PR 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E M6PR 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 M6PR 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 M6PR 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 M6PR 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F M6PR 20371350 21572407 22473208 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 M6PR 20371350 21572407 22473208 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B7450 M6PR 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000024CEE0 M6PR 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 M6PR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 M6PR 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 M6PR 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 M6PR 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000058878F M6PR 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 M6PR 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 M6PR 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 M6PR 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD M6PR 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 M6PR 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA M6PR 20371350 21572407 22473208 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 M6PR 20371350 21572407 22473208 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 M6PR 20371350 21572407 22473208 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 M6PR 20371350 21572407 22473208 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
M6PR PLIN3 25361965 interaction type N/A PTMCode2
PLIN3 M6PR 25361965 interaction type N/A PTMCode2
M6PR GGA3 25361965 interaction type N/A PTMCode2
GGA3 M6PR 25361965 interaction type N/A PTMCode2
M6PR GGA2 25361965 interaction type N/A PTMCode2
GGA2 M6PR 25361965 interaction type N/A PTMCode2
M6PR GGA1 25361965 interaction type N/A PTMCode2
GGA1 M6PR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RPS28 M6PR 25348397 N/A physical interaction ComPPI
RPL37A M6PR 25348397 N/A physical interaction ComPPI
TAFA1 M6PR 25348397 N/A physical interaction ComPPI
TAFA4 M6PR 25348397 N/A physical interaction ComPPI
DUSP12 M6PR 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GGA2 M6PR 11387475 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
JUN M6PR 25348397 N/A physical interaction ComPPI
ACOX1 M6PR 25348397 N/A physical interaction ComPPI
ENO1 M6PR 25348397 N/A physical interaction ComPPI
REN M6PR 14525934 25348397 27898060 2960682 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TCP1 M6PR 24234451 24846140 25348397 colocalization fluorescence microscopy ComPPI,IntAct
GGA3 M6PR 11387475 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
GGA1 M6PR 11387475 14525934 15044437 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
PLIN3 M6PR 10829017 14525934 25348397 27898060 9590177 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
RANBP2 M6PR 25348397 N/A physical interaction ComPPI
RPL6 M6PR 25348397 N/A physical interaction ComPPI
M6PR ACP2 25348397 N/A physical interaction ComPPI
M6PR HPDL 25348397 N/A physical interaction ComPPI
M6PR NDUFS4 25348397 N/A physical interaction ComPPI
M6PR NDUFB4 25348397 N/A physical interaction ComPPI
M6PR ATP4A 25348397 N/A physical interaction ComPPI
M6PR FBXO6 25348397 N/A physical interaction ComPPI
M6PR MOV10 25348397 N/A physical interaction ComPPI
M6PR NXF1 25348397 N/A physical interaction ComPPI
M6PR PON2 25348397 N/A physical interaction ComPPI
M6PR DUSP9 25348397 N/A physical interaction ComPPI
M6PR LRP2 21971085 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
M6PR OLR1 24234451 24846140 25348397 colocalization fluorescence microscopy ComPPI,IntAct
M6PR NINJ2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
M6PR GIMAP5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

Visualization










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