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GENE：CRADD

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CRADD
FullNmae CASP2 and RIPK1 domain containing adaptor with death domain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2340
EnsembleID ENSG00000169372
Uniprot P78560

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CRADD parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CRADD necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CRADD mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CRADD autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CRADD apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CRADD apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CRADD GO:0002020,GO:0002020,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005737,GO:0005829,GO:0006919,GO:0006974,GO:0006977,GO:0006977,GO:0008625,GO:0030674,GO:0043065,GO:0043065,GO:0070513,GO:0071260,GO:0071260,GO:0097190,GO:1905369,GO:2001235

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL10 CRADD 11356195 16818229 17052756 17462996 18264101 21199863 22323537 26192618 association N/A ACSN
APP CRADD 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
PIDD1 CRADD 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR CRADD 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 CRADD 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 CRADD 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CRADD 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 CRADD 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CRADD 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CRADD 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CRADD 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CRADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC CRADD N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CRADD 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000427B68 CRADD 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB CRADD 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000002CF68 CRADD 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028C188 CRADD 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 CRADD 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
KCTD9 CRADD 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRYAB CRADD 25348397 N/A physical interaction ComPPI
KPNA1 CRADD 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
WIF1 CRADD 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
VTN CRADD 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP8 CRADD 11002417 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TNFRSF1A CRADD 25348397 N/A physical interaction ComPPI
EEF1A1 CRADD 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HNRNPL CRADD 25348397 N/A physical interaction ComPPI
ACTN2 CRADD 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
RIPK1 CRADD 14525934 25348397 8985253 9044836 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL9R CRADD 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP2 CRADD 11156409 11832478 14525934 15073321 16652156 24234451 25348397 25416956 27107012 8985253 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
LRIF1 CRADD 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CRADD PIDD1 14525934 15073321 16652156 17159900 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
CRADD ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CRADD CCSER2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CRADD EEF1A1P5 25348397 N/A physical interaction ComPPI
CRADD APP 25348397 N/A physical interaction ComPPI
CRADD SLC35A3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CRADD APPL2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRADD TRIM54 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRADD BBS5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRADD RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DCXR CRADD 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTGER4 CRADD 24234451 28298427 physical association ubiquitin reconstruction IntAct
TSHR CRADD 24234451 28298427 physical association ubiquitin reconstruction IntAct
PIDD1 CRADD 15073321 16189514 16360037 16652156 17159900 17289572 17329820 18845684 19203584 20406701 20872280 20935634 20966961 21415862 23049853 27898060 stimulant N/A OmniPath
CRADD CASP2 11156409 11832478 15073321 16652156 23049853 25416956 27898060 8985253 9695946 stimulant N/A OmniPath
CRADD RIPK1 27898060 8985253 9044836 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C168C CRADD 27087310 direct interaction,inhibition N/A NPInter

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