GENE：BRSK1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BRSK1 |
| FullNmae | BR serine/threonine kinase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18994 |
| EnsembleID | ENSG00000160469 |
| Uniprot | Q8TDC3 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BRSK1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BRSK1 | GO:0000086,GO:0000287,GO:0004674,GO:0004674,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005813,GO:0006468,GO:0006468,GO:0006468,GO:0006974,GO:0007095,GO:0007269,GO:0007409,GO:0007409,GO:0008021,GO:0008021,GO:0008306,GO:0009411,GO:0010975,GO:0018105,GO:0019901,GO:0030010,GO:0030010,GO:0030054,GO:0030182,GO:0035556,GO:0043015,GO:0048156,GO:0048167,GO:0048786,GO:0050321,GO:0050321,GO:0050321,GO:0050321,GO:0050770,GO:0051298,GO:0090176,GO:0099504,GO:0106310,GO:0150034,GO:2000807 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | BRSK1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | BRSK1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | BRSK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | BRSK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | BRSK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | BRSK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003FD55 | BRSK1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005485E8 | BRSK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000235862 | BRSK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BE495 | BRSK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032835F | BRSK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| STK11 | BRSK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PAK1 | BRSK1 | 22669945 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PRKAA1 | BRSK1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1A | BRSK1 | 14525934 16306228 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| HSPA1B | BRSK1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PKM | BRSK1 | 25348397 | N/A | protein kinase assay | ComPPI |
| WEE1 | BRSK1 | 14525934 15150265 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| BRSK1 | CDC25B | 25348397 | N/A | in vitro | ComPPI |
| BRSK1 | CDC25C | 14525934 15150265 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| BRSK1 | HSD17B7 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| BRSK1 | BRCA1 | 25348397 | N/A | physical interaction | ComPPI |
| H2BC20P | BRSK1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| BRSK1 | CDC25B | 12527891 15150265 16861915 27898060 | inhibition | N/A | OmniPath |
| STK11 | BRSK1 | 14976552 16630837 18339622 27898060 | stimulant | N/A | OmniPath |
| BRSK1 | CDC25C | 10557092 11333986 11551930 15150265 20068231 27898060 9278512 9543386 | inhibition | N/A | OmniPath |
| BRSK1 | TUBG1 | 19648910 24942739 27898060 | stimulant | N/A | OmniPath |