GENE：MTHFD2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MTHFD2 |
| FullNmae | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7434 |
| EnsembleID | ENSG00000065911 |
| Uniprot | P13995 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MTHFD2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MTHFD2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MTHFD2 | GO:0000287,GO:0000287,GO:0004477,GO:0004477,GO:0004477,GO:0004477,GO:0004487,GO:0004487,GO:0004487,GO:0004487,GO:0004488,GO:0004488,GO:0004488,GO:0005515,GO:0005615,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0035999,GO:0042301,GO:0042301,GO:0046653,GO:0046655 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MTHFD2 | hsa:10797 | path:hsa00670 | One carbon pool by folate - Homo sapiens (human) |
| MTHFD2 | hsa:10797 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| MTHFD2 | hsa:10797 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MTHFD2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MTHFD2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | MTHFD2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | MTHFD2 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | MTHFD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000338542 | MTHFD2 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00004505E4 | MTHFD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001DE669 | MTHFD2 | 23446348 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS0000272A3D | MTHFD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000005CF5F | MTHFD2 | 23446348 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS0000065D58 | MTHFD2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A25B | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008AA34 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000038718E | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000260A3A | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BC299 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E628F | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A8BB2 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000496C56 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000319E1 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037B2E0 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000118224 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004283FE | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AEA5 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B13F | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD02D | MTHFD2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | MTHFD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027080C | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | MTHFD2 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EEE35 | MTHFD2 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020CEC2 | MTHFD2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E728C | MTHFD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005FDE70 | MTHFD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | MTHFD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000160683 | MTHFD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | MTHFD2 | 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | MTHFD2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | MTHFD2 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237E04 | MTHFD2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013E79D | MTHFD2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005A8ED | MTHFD2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | MTHFD2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000048BA36 | MTHFD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | MTHFD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000544FF1 | MTHFD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EBD4B | MTHFD2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000214763 | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000047A8F | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A6D0C | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007A060 | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A939F | MTHFD2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GCC1 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| LMNA | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| HRAS | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| NFATC1 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| DLD | MTHFD2 | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| NAGK | MTHFD2 | 21516116 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| NFATC2 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| HUWE1 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| TFCP2 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| PTEN | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| ATXN3 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| CLIC1 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| PDK1 | MTHFD2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| ELAVL1 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| SRP9 | MTHFD2 | 25348397 | N/A | physical interaction | ComPPI |
| HSPD1 | MTHFD2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MCC | MTHFD2 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PSMD13 | MTHFD2 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PARP3 | MTHFD2 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MTHFD2 | UBP1 | 25348397 | N/A | physical interaction | ComPPI |
| MTHFD2 | LRRK2 | 24234451 24725412 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| MTHFD2 | DAPK1 | 24234451 25348397 29513927 | N/A | protein array | ComPPI,IntAct |
| TRMT61B | MTHFD2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |