GENE：COL3A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | COL3A1 |
| FullNmae | collagen type III alpha 1 chain |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2201 |
| EnsembleID | ENSG00000168542 |
| Uniprot | P02461 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| COL3A1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| COL3A1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| COL3A1 | GO:0001701,GO:0001764,GO:0001894,GO:0002020,GO:0002062,GO:0005178,GO:0005178,GO:0005201,GO:0005515,GO:0005576,GO:0005576,GO:0005586,GO:0005586,GO:0005586,GO:0005586,GO:0005615,GO:0005615,GO:0005615,GO:0005788,GO:0007160,GO:0007179,GO:0007229,GO:0007507,GO:0009314,GO:0018149,GO:0021819,GO:0021987,GO:0030020,GO:0030020,GO:0030020,GO:0030168,GO:0030198,GO:0030199,GO:0030199,GO:0030324,GO:0032905,GO:0034097,GO:0035025,GO:0035264,GO:0036022,GO:0042060,GO:0042060,GO:0043588,GO:0046332,GO:0046872,GO:0048144,GO:0048251,GO:0048407,GO:0048565,GO:0050777,GO:0060350,GO:0060414,GO:0062023,GO:0062023,GO:0062023,GO:0062023,GO:0071230,GO:0071711,GO:0097435,GO:1990776,GO:2001223 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| COL3A1 | hsa:1281 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| COL3A1 | hsa:1281 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| COL3A1 | hsa:1281 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| COL3A1 | hsa:1281 | path:hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| COL3A1 | hsa:1281 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
| COL3A1 | hsa:1281 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | COL3A1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CTCF | COL3A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | COL3A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | COL3A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | COL3A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | COL3A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | COL3A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD1 | COL3A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | COL3A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272A3D | COL3A1 | N/A 18390668 \N | rna interference,inhibition | experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000272A3D | COL3A1 | 18390668 18927107 22745231 25416803 26453978 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miR2Disease,TarBase |
| URS0000237AF9 | COL3A1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000076995 | COL3A1 | 22745231 25416803 25786138 26199111 | mrna cleavage,inhibition | experimental interaction detection,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00000AD002 | COL3A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000324096 | COL3A1 | 22995917 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000045147B | COL3A1 | 22745231 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000008A99 | COL3A1 | 24283360 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr | TarBase |
| URS00001123BD | COL3A1 | 25416803 25827718 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000A07C1 | COL3A1 | 25193015 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SP1 | COL3A1 | 25348397 | N/A | physical interaction | ComPPI |
| DDR1 | COL3A1 | 14525934 25348397 9659900 | N/A | experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vivo,solid phase assay | ComPPI,HPRD |
| SPARC | COL3A1 | 14525934 19011090 25348397 2745554 27898060 | N/A | experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| THBS1 | COL3A1 | 14525934 25348397 3571333 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PCOLCE | COL3A1 | 12105202 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| PDGFB | COL3A1 | 25348397 | N/A | physical interaction | ComPPI |
| PDGFA | COL3A1 | 25348397 | N/A | physical interaction | ComPPI |
| DDR2 | COL3A1 | 14525934 25348397 9659899 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| VWF | COL3A1 | 25348397 | N/A | physical interaction | ComPPI |
| TFAP2C | COL3A1 | 24234451 24835590 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CAND1 | COL3A1 | 25348397 | N/A | physical interaction | ComPPI |
| COL3A1 | CAPN1 | 12358155 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| COL3A1 | FGF7 | 11973338 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| COL3A1 | MAG | 14525934 2446864 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| COL3A1 | MYOC | 14525934 16289162 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| COL3A1 | HTRA1 | 14525934 15101818 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| COL3A1 | LOX | 21690299 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| COL3A1 | ERAL1 | 25348397 | N/A | physical interaction | ComPPI |