Gene Information gene info

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GENE：ITGB8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGB8
FullNmae integrin subunit beta 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6163
EnsembleID ENSG00000105855
Uniprot P26012

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGB8 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGB8 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITGB8 GO:0001570,GO:0001573,GO:0005178,GO:0005886,GO:0005925,GO:0006955,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0007229,GO:0008305,GO:0009615,GO:0009986,GO:0009986,GO:0010628,GO:0010629,GO:0016477,GO:0033627,GO:0034686,GO:0034686,GO:0045766,GO:0046872,GO:0051216,GO:0060022,GO:0060674,GO:0061520,GO:0070062,GO:1901388,GO:1901388,GO:1990430

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGB8 hsa:3696 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa04510 Focal adhesion - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ITGB8 hsa:3696 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTNNB1 ITGB8 23180781 26515729 physical association anti tag coimmunoprecipitation InnateDB
ITGB8 TGFB1 11970960 20870411 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ITGB8 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ITGB8 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ITGB8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 ITGB8 21878622 trascriptional regulation,stimulation inferred by curator TFlink
JUN ITGB8 21878622 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 ITGB8 21701675 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000DDD35 ITGB8 20956944 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000DDD35 ITGB8 20956944 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000013D17D ITGB8 22197821 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004F4657 ITGB8 21701675 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 ITGB8 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA ITGB8 23602254 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000042E1F ITGB8 23602254 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BBF48 ITGB8 21703006 23592263 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000000C73C ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD231 ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF ITGB8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D ITGB8 22473208 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1B ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008931A ITGB8 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD ITGB8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020CEC2 ITGB8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 ITGB8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 ITGB8 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 ITGB8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 ITGB8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000B989F ITGB8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000013DD8 ITGB8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001A7F58 ITGB8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ITGB8 VTN 25361965 interaction type N/A PTMCode2
VTN ITGB8 25361965 interaction type N/A PTMCode2
ITGB8 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV ITGB8 25361965 interaction type N/A PTMCode2
TGFB1 ITGB8 25361965 interaction type N/A PTMCode2
ITGB8 TGFB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TGFB1 ITGB8 11970960 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGAV ITGB8 14525934 1918072 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
VTN ITGB8 11156415 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB8 RHEB 25348397 N/A physical interaction ComPPI
ITGB8 SLC25A16 25348397 N/A physical interaction ComPPI
ITGB8 GINM1 25348397 N/A physical interaction ComPPI
ITGB8 LMF1 25348397 N/A physical interaction ComPPI
ITGB8 GET1 25348397 N/A physical interaction ComPPI
ITGB8 NME4 25348397 N/A physical interaction ComPPI
ITGB8 ACTR3C 25348397 N/A physical interaction ComPPI
ITGB8 L2HGDH 25348397 N/A physical interaction ComPPI
ITGB8 B3GNT2 25348397 N/A physical interaction ComPPI
ITGB8 RHBDL1 25348397 N/A physical interaction ComPPI
ITGB8 TIMM29 25348397 N/A physical interaction ComPPI
RPL23 ITGB8 25348397 N/A physical interaction ComPPI
LAMB1 ITGB8 27898060 7542940 stimulant N/A OmniPath
LAMA1 ITGB8 27898060 7542940 stimulant N/A OmniPath
DUSP18 ITGB8 27898060 7542940 stimulant N/A OmniPath

Visualization










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