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GENE：OPTN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol OPTN
FullNmae optineurin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17142
EnsembleID ENSG00000123240
Uniprot Q96CV9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
OPTN mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
OPTN autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
OPTN autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
OPTN autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
OPTN GO:0000139,GO:0001920,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005794,GO:0005794,GO:0005802,GO:0005829,GO:0005829,GO:0006914,GO:0007030,GO:0007165,GO:0008219,GO:0010508,GO:0030674,GO:0031593,GO:0034067,GO:0034067,GO:0034620,GO:0042802,GO:0043001,GO:0043122,GO:0043124,GO:0045087,GO:0046872,GO:0048471,GO:0050829,GO:0055038,GO:0061734,GO:0070530,GO:0090161,GO:0090161,GO:0090161,GO:1904417

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
OPTN hsa:10133 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
OPTN hsa:10133 path:hsa04140 Autophagy - animal - Homo sapiens (human)
OPTN hsa:10133 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
OPTN hsa:10133 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TBK1 OPTN 18307994 20174559 21903422 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
OPTN RIPK1 17702576 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TRADD OPTN 17702576 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3 OPTN 20174559 23180781 physical association pull down InnateDB
OPTN TRAF3 20174559 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN TBK1 20174559 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN UBC 19285159 23180781 physical association protein array InnateDB
OPTN YWHAH 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN KCTD17 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN PALS2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN ZNF384 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN YWHAG 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN YWHAQ 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN YWHAZ 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN EIF5A2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN YWHAB 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
OPTN MPP1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
FOXP3 OPTN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
IRF1 OPTN 23811275 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 OPTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA OPTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF OPTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 OPTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 OPTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A OPTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 OPTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 OPTN 19340308 trascriptional regulation,stimulation inferred by curator TFlink
RELA OPTN 19340308 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 OPTN 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA OPTN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000008A99 OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 OPTN 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TBK1 OPTN 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK1 OPTN 22135298 phosphorylation N/A PhosphoSite
IKBKB OPTN 22135298 phosphorylation N/A PhosphoSite
OPTN RAB10 25361965 interaction type N/A PTMCode2
RAB10 OPTN 25361965 interaction type N/A PTMCode2
OPTN TBK1 25361965 interaction type N/A PTMCode2
OPTN HTT 25361965 interaction type N/A PTMCode2
HTT OPTN 25361965 interaction type N/A PTMCode2
OPTN GTF3A 25361965 interaction type N/A PTMCode2
GTF3A OPTN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZMAT2 OPTN 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
WASHC3 OPTN 14525934 16189514 21516116 24234451 25348397 25416956 25910212 26871637 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
RAB14 OPTN 25348397 N/A physical interaction ComPPI
TFRC OPTN 25348397 N/A physical interaction ComPPI
STX12 OPTN 25348397 N/A physical interaction ComPPI
FTH1 OPTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
CDKN1A OPTN 19609363 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ARRDC3 OPTN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPL37A OPTN 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ZNF329 OPTN 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VCP OPTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ZNF670 OPTN 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GABARAPL2 OPTN 25348397 N/A physical interaction ComPPI
YWHAG OPTN 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CALM1 OPTN 25348397 N/A physical interaction ComPPI
TNIP1 OPTN 21516116 21988832 23414517 24234451 25348397 25416956 25910212 26871637 30561431 association,physical association two hybrid,physical interaction,two hybrid array,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,virotrap ComPPI,IntAct
OPTN RAB10 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
OPTN RAB8A 11137014 14525934 20085643 20161783 20388642 20634958 22854040 23357852 24234451 25348397 27898060 colocalization,physical association two hybrid,physical interaction,confocal microscopy,bimolecular fluorescence complementation,two hybrid ComPPI,HPRD,IntAct,OmniPath
OPTN FLII 10366446 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
OPTN GTF3A 10756201 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
OPTN RAB11B 11495908 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
OPTN TBC1D17 16189514 22854040 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,confocal microscopy ComPPI,IntAct
OPTN HTT 11137014 14525934 17500595 23275563 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
OPTN RNF11 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
OPTN WDR20 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN CYLD 25348397 N/A physical interaction ComPPI
OPTN RIPK1 25348397 N/A physical interaction ComPPI
OPTN TAX1BP1 25348397 N/A physical interaction ComPPI
OPTN KCTD17 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN MPP1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN PALS2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN TBK1 18307994 21903422 23414517 24234451 25348397 27086836 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
OPTN YWHAB 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN YWHAH 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN YWHAZ 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN ZNF384 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN GABARAPL1 25348397 N/A physical interaction ComPPI
OPTN MAP1LC3A 25348397 N/A physical interaction ComPPI
OPTN MAP1LC3B 24234451 25026213 25348397 physical association pull down,physical interaction ComPPI,IntAct
OPTN UBC 17702576 18212736 19285159 21408173 21617041 21862579 23178947 23414517 24234451 25348397 25969509 26365381 26451915 27898060 physical association physical interaction,two hybrid fragment pooling approach ComPPI,IntAct,OmniPath
OPTN TRAF3 25348397 N/A physical interaction ComPPI
OPTN MYO6 25348397 N/A physical interaction ComPPI
OPTN GRM1 16091361 25348397 27898060 N/A physical interaction ComPPI,OmniPath
OPTN TRADD 25348397 N/A physical interaction ComPPI
OPTN SOD1 25348397 N/A physical interaction ComPPI
OPTN TNFRSF1A 25348397 N/A physical interaction ComPPI
OPTN TNF 25348397 N/A physical interaction ComPPI
OPTN RAB11A 16905101 17626244 24056041 25348397 27898060 N/A physical interaction ComPPI,OmniPath
OPTN EPS15 25348397 N/A physical interaction ComPPI
OPTN PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OPTN RAB12 25348397 N/A physical interaction ComPPI
OPTN UQCRQ 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
OPTN SLF2 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
OPTN GNAS 25348397 N/A physical interaction ComPPI
OPTN GNAS 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
OPTN GNAS 25348397 N/A physical interaction ComPPI
OPTN BABAM2 25348397 N/A physical interaction ComPPI
OPTN RAB25 25348397 N/A physical interaction ComPPI
OPTN HACE1 24234451 25026213 25348397 ubiquitination reaction,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,fluorescence microscopy,ubiquitinase assay ComPPI,IntAct
OPTN SQSTM1 24234451 25026213 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN PRKN 25348397 N/A physical interaction ComPPI
OPTN CDC23 21516116 24234451 25348397 25416956 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid ComPPI,IntAct
OPTN DAZAP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
OPTN ZNF398 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
OPTN TBC1D15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
OPTN ZDHHC17 24234451 24705354 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OPTN GABARAP 25348397 N/A physical interaction ComPPI
OPTN RAB3IL1 25348397 N/A physical interaction ComPPI
OPTN HSPB1 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
OPTN LNX2 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OPTN FAM189A2 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OPTN NRL 23956131 25348397 27898060 N/A physical interaction ComPPI,OmniPath
OPTN MAP1LC3C 25348397 N/A physical interaction ComPPI
OPTN MYH6 25348397 N/A physical interaction ComPPI
OPTN ATG5 25348397 N/A physical interaction ComPPI
OPTN IKBKG 25348397 N/A physical interaction ComPPI
OPTN CASP8 25348397 N/A physical interaction ComPPI
OPTN AIMP1 25348397 N/A physical interaction ComPPI
OPTN ZMYM6 25348397 N/A physical interaction ComPPI
OPTN TRIM16 25348397 N/A physical interaction ComPPI
OPTN IRAK1 25348397 N/A physical interaction ComPPI
OPTN ATG16L1 25348397 N/A physical interaction ComPPI
OPTN WIPI2 25348397 N/A physical interaction ComPPI
OPTN MACF1 25348397 N/A display technology ComPPI
OPTN EIF4G2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN CENPB 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN NDUFAF2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN RTN3 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN SYNGAP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN EBNA1BP2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN ABRAXAS2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN PPARG 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
OPTN DST 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
OPTN NEB 23414517 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
OPTN VWF 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
OPTN SNX6 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
OPTN DYSF 23414517 24234451 25348397 colocalization,physical association two hybrid fragment pooling approach,confocal microscopy,proximity ligation assay ComPPI,IntAct
OPTN TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
OPTN AKAP6 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
OPTN KANSL1L 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN CLTC 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN CMYA5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN DZIP1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN MYH3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN ZNF181 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN ZNF302 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN ZNF426 23414517 24234451 25348397 physical association two hybrid array,two hybrid fragment pooling approach,two hybrid prey pooling approach ComPPI,IntAct
OPTN ZNF711 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
OPTN ZNF17 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OPTN SDCBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OPTN USP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OPTN RBM12 24234451 25348397 25910212 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
OPTN PICK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OPTN RNF216 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OPTN POU6F2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OPTN HSF2BP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OPTN CCDC13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBB OPTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
YWHAQ OPTN 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA9 OPTN 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
EIF5A2 OPTN 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLMAP OPTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
OPTN FOS 14525934 15867431 N/A experimental interaction detection HPRD
OPTN OPTN 23414517 24234451 24983867 25416956 25910212 26871637 physical association anti tag coimmunoprecipitation,two hybrid array,two hybrid fragment pooling approach,proximity ligation assay,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid IntAct
BIRC2 OPTN 24234451 30561431 association virotrap IntAct
TNFAIP3 OPTN 24234451 30561431 association virotrap IntAct
PLK1 OPTN 21617041 21862579 22365832 26266977 26365381 26376340 27898060 stimulant N/A OmniPath
OPTN TRADD 17702576 27898060 N/A N/A OmniPath
OPTN RIPK1 17702576 21408173 22675546 27898060 N/A N/A OmniPath
OPTN TBK1 18307994 20174559 21862579 21903422 23414517 25803835 26365381 27898060 N/A N/A OmniPath
TBK1 OPTN 18307994 20174559 21617041 21862579 21903422 23414517 25803835 26365381 27898060 stimulant N/A OmniPath
OPTN TRAF3 20174559 27898060 N/A N/A OmniPath

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