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GENE：PDE10A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDE10A
FullNmae phosphodiesterase 10A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8772
EnsembleID ENSG00000112541
Uniprot Q9Y233

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDE10A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PDE10A GO:0004114,GO:0004115,GO:0004118,GO:0004118,GO:0005829,GO:0006198,GO:0007165,GO:0010754,GO:0030552,GO:0030552,GO:0030553,GO:0046069,GO:0046872,GO:0047555

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDE10A hsa:10846 path:hsa00230 Purine metabolism - Homo sapiens (human)
PDE10A hsa:10846 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PDE10A hsa:10846 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PDE10A hsa:10846 path:hsa05032 Morphine addiction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PDE10A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PDE10A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PDE10A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004C5774 PDE10A 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB PDE10A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 PDE10A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F PDE10A 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 PDE10A 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CASP3 PDE10A 11602184 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HNRNPL PDE10A 25348397 N/A physical interaction ComPPI
PDE10A TOP1 25348397 N/A physical interaction ComPPI
PDE10A WDR3 14525934 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct

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