Gene Information gene info

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GENE：EIF5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF5
FullNmae eukaryotic translation initiation factor 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3299
EnsembleID ENSG00000100664
Uniprot P55010

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EIF5 GO:0001731,GO:0001732,GO:0003723,GO:0003743,GO:0005092,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0006446,GO:0042255,GO:0045202,GO:0045296,GO:0071074

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP EIF5 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 EIF5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EIF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D EIF5 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000021D7C8 EIF5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003ABC4 EIF5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000079F78 EIF5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005C1F22 EIF5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 EIF5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 EIF5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 EIF5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F EIF5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 EIF5 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 EIF5 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HNRNPK EIF5 25348397 N/A physical interaction ComPPI
GNAI3 EIF5 25348397 N/A physical interaction ComPPI
EIF3G EIF5 14525934 25348397 9973622 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TUBB EIF5 25348397 N/A physical interaction ComPPI
EIF2B2 EIF5 25348397 N/A physical interaction ComPPI
SNRPD1 EIF5 25348397 N/A physical interaction ComPPI
LMNA EIF5 25348397 N/A physical interaction ComPPI
DUSP12 EIF5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EIF5 EIF1AX 10982835 14525934 24234451 25348397 27898060 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
EIF5 EIF1AY 12569173 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EIF5 EIF2S2 10805737 11092890 14525934 25348397 9395514 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EIF5 EIF3D 11331597 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EIF5 NCBP2 11331597 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EIF5 EIF4G1 25348397 N/A in vitro,in vivo ComPPI
EIF5 EIF4G2 25348397 N/A in vitro ComPPI
EIF5 CSNK2A1 11861906 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EIF5 CSNK2B 11861906 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EIF5 APP 25348397 N/A physical interaction ComPPI
EIF5 EIF3B 25348397 N/A physical interaction ComPPI
EIF5 RPL29 25348397 N/A physical interaction ComPPI
EIF5 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
EIF5 PUM1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EIF5 NRGN 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EIF5 DFFA 25348397 N/A physical interaction ComPPI
EIF5 EIF4H 25348397 N/A physical interaction ComPPI
EIF5 ALDH7A1 25348397 N/A physical interaction ComPPI
EIF5 FERMT2 25348397 N/A physical interaction ComPPI
EIF5 G6PD 25348397 N/A physical interaction ComPPI
EIF5 PFAS 25348397 N/A physical interaction ComPPI
EIF5 STK24 25348397 N/A physical interaction ComPPI
EIF5 VCL 25348397 N/A physical interaction ComPPI
EIF5 GLA 25348397 N/A physical interaction ComPPI
EIF5 MAT2B 25348397 N/A physical interaction ComPPI
EIF5 PAFAH1B1 25348397 N/A physical interaction ComPPI
EIF5 PCYT2 25348397 N/A physical interaction ComPPI
EIF5 PDHB 25348397 N/A physical interaction ComPPI
EIF5 SCLY 25348397 N/A physical interaction ComPPI
EIF5 TBCB 25348397 N/A physical interaction ComPPI
EIF5 UBFD1 25348397 N/A physical interaction ComPPI
EIF5 YWHAE 25348397 N/A physical interaction ComPPI
EIF5 YWHAH 25348397 N/A physical interaction ComPPI
EIF5 YWHAZ 25348397 N/A physical interaction ComPPI
EIF5 HUWE1 25348397 N/A physical interaction ComPPI
EIF5 RPS6 25348397 N/A physical interaction ComPPI
EIF5 SLC30A4 25348397 N/A physical interaction ComPPI
EIF5 HSPB1 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
EIF5 BZW2 25348397 N/A physical interaction ComPPI
EIF5 CHD4 25348397 N/A physical interaction ComPPI
EIF5 CHD5 25348397 N/A physical interaction ComPPI
EIF5 EIF1 25348397 N/A physical interaction ComPPI
EIF5 EIF2S1 25348397 N/A physical interaction ComPPI
EIF5 EIF3I 25348397 N/A physical interaction ComPPI
EIF5 BZW1 25348397 N/A physical interaction ComPPI
EIF5 SRSF2 25348397 N/A physical interaction ComPPI
EIF5 NTRK1 25348397 N/A physical interaction ComPPI
EIF5 XPO1 25348397 N/A physical interaction ComPPI
EIF5 CDH1 25348397 N/A physical interaction ComPPI
EIF5 CLPB 25348397 N/A physical interaction ComPPI
EIF5 TXNIP 25348397 N/A physical interaction ComPPI
EIF5 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF5 DDX3X 18596238 24234451 25348397 colocalization cosedimentation,cosedimentation in solution ComPPI,IntAct
EIF5 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAQ EIF5 25348397 N/A physical interaction ComPPI
HSPA9 EIF5 25348397 N/A physical interaction ComPPI
CAPNS1 EIF5 25348397 N/A physical interaction ComPPI
DDA1 EIF5 25348397 N/A physical interaction ComPPI
ISOC1 EIF5 25348397 N/A physical interaction ComPPI
EIF5 EIF2S1 27898060 9395514 inhibition,stimulant N/A OmniPath
CSNK2A1 EIF5 11861906 16227438 17287340 18452278 18649047 18669648 18691976 19413330 19415658 19651622 20068231 27898060 stimulant N/A OmniPath
CSNK2B EIF5 11861906 17287340 18452278 18669648 18691976 19413330 19415658 19651622 20068231 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B0EBF EIF5 27087310 direct interaction,inhibition N/A NPInter
URS00009B5555 EIF5 27087310 direct interaction,inhibition N/A NPInter

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