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GENE：APPBP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APPBP2
FullNmae amyloid beta precursor protein binding protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:622
EnsembleID ENSG00000062725
Uniprot Q92624

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APPBP2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
APPBP2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APPBP2 GO:0003777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005874,GO:0005875,GO:0006886,GO:0016567,GO:0030659,GO:0031462,GO:0031462,GO:0043161,GO:0043161,GO:0046907,GO:1990756,GO:1990756

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CUL3 APPBP2 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB
AHCY APPBP2 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 APPBP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 APPBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003BBF48 APPBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000013ABA3 APPBP2 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000330617 APPBP2 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001B341F APPBP2 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E92A8 APPBP2 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A2C49 APPBP2 24398324 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
APPBP2 APP 25361965 interaction type N/A PTMCode2
APP APPBP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF232 APPBP2 25348397 N/A physical interaction ComPPI
ZNF408 APPBP2 25348397 N/A physical interaction ComPPI
ZCCHC12 APPBP2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TCF25 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRKAA2 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FXYD7 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SYT11 APPBP2 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
C1QTNF2 APPBP2 25348397 N/A physical interaction ComPPI
WAS APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TNP2 APPBP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GSTP1 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CSNK1G2 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ITGB5 APPBP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
C6ORF226 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CALM1 APPBP2 25348397 N/A two hybrid,physical interaction ComPPI
ZC3H10 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RASSF5 APPBP2 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
KBTBD7 APPBP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPBP2 AIM2 25348397 N/A two hybrid,physical interaction ComPPI
APPBP2 DPEP1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 PRKACB 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 TBL3 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
APPBP2 RRS1 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
APPBP2 ARMCX5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 PYROXD2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 HIPK4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 ERO1A 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 TAFA4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 C1ORF50 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 LANCL2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 CNTFR 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 MLLT3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 NFYA 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 WNT5B 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 CREB3 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
APPBP2 MUL1 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 PCSK5 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 KIF6 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 SLC22A6 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 MFSD3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 CHMP5 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 WDR24 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
APPBP2 EID3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APPBP2 AR 14525934 14729952 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
APPBP2 APP 14525934 19570594 25348397 27898060 9843960 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
APPBP2 SCFD1 25348397 N/A physical interaction ComPPI
APPBP2 UBC 25348397 N/A physical interaction ComPPI
APPBP2 ELOB 25348397 N/A physical interaction ComPPI
APPBP2 ELOC 25348397 N/A physical interaction ComPPI
APPBP2 CUL2 25348397 N/A physical interaction ComPPI
APPBP2 COPS6 25348397 N/A physical interaction ComPPI
APPBP2 FAM92A 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
APPBP2 GP9 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
APPBP2 FSTL1 19060904 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 AHCY 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 GALNT3 25348397 N/A physical interaction ComPPI
APPBP2 HSPA4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 CDK16 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 PPP1R8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 TAF11 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 NPRL3 25348397 N/A physical interaction ComPPI
APPBP2 KLF11 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 DHRS2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 CORO2B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 SYNRG 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 SNX5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 ST8SIA5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 AK3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 LUZP4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 LUC7L2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 ANKRD10 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 UGGT2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 CCNL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 ZNF747 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 SLC25A23 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 RNF128 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 LONRF3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 CTC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 RNF34 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 SELENOI 25348397 N/A physical interaction ComPPI
APPBP2 DCD 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 COL24A1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 GCSAM 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 KLHL35 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 CCDC85C 25348397 N/A physical interaction ComPPI
APPBP2 SELENOV 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
APPBP2 IKBKE 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPBP2 XRCC4 25348397 N/A physical interaction ComPPI
APPBP2 SKAP1 25348397 N/A physical interaction ComPPI
APPBP2 COPS2 25348397 N/A physical interaction ComPPI
APPBP2 COPS3 25348397 N/A physical interaction ComPPI
APPBP2 AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPBP2 RASSF8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPBP2 SLAIN2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPBP2 COPS8 25348397 N/A physical interaction ComPPI
APPBP2 GLMN 25348397 N/A physical interaction ComPPI
APPBP2 COPS7B 25348397 N/A physical interaction ComPPI
APPBP2 DOCK8 25348397 N/A physical interaction ComPPI
APPBP2 INTU 25348397 N/A physical interaction ComPPI
APPBP2 MYCL 25348397 N/A physical interaction ComPPI
APPBP2 IKZF1 25348397 N/A physical interaction ComPPI
APPBP2 THOC3 25348397 N/A physical interaction ComPPI
APPBP2 NPRL2 25348397 N/A physical interaction ComPPI
APPBP2 FBXL5 25348397 N/A physical interaction ComPPI
APPBP2 GNA15 25348397 N/A physical interaction ComPPI
APPBP2 ZNF785 25348397 N/A physical interaction ComPPI
APPBP2 DQX1 25348397 N/A physical interaction ComPPI
APPBP2 ZIM2 25348397 N/A physical interaction ComPPI
APPBP2 GATAD2A 25348397 N/A physical interaction ComPPI
APPBP2 USP25 25348397 N/A physical interaction ComPPI
APPBP2 THSD4 25348397 N/A physical interaction ComPPI
APPBP2 FAM107A 25348397 N/A physical interaction ComPPI
APPBP2 PI4KAP2 16189514 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
APPBP2 SLC9A3R1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 RAB7B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 RNGTT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 MCOLN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 ACTN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 PSAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 HSD3B7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 RHEB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 MGAT4B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 TRMT2A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 MSH2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 DPYS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 AADAC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 SLC7A10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 DOLK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 PPIL6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 BIN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 SPDYE6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 PNPLA5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 WFIKKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 MAN2B2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 CCDC167 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 HGFAC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
H2AC11 APPBP2 25348397 N/A two hybrid,physical interaction ComPPI
CLCN1 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2R2 APPBP2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CST2 APPBP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APPBP2 APPBP2 14525934 9843960 N/A experimental interaction detection HPRD
APPBP2 EDC3 18086885 24830408 27898060 N/A N/A OmniPath
POLR2G APPBP2 17875743 24358479 24513203 27898060 N/A N/A OmniPath
LSM1 APPBP2 10747033 10761922 10913177 17513695 18086885 18719247 19111170 19643916 22450758 23847025 24247251 27898060 N/A N/A OmniPath

Visualization










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