GENE：ABRAXAS1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ABRAXAS1 |
| FullNmae | abraxas 1, BRCA1 A complex subunit |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:25829 |
| EnsembleID | ENSG00000163322 |
| Uniprot | Q6UWZ7 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ABRAXAS1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ABRAXAS1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ABRAXAS1 | GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0006282,GO:0006302,GO:0006325,GO:0007095,GO:0008017,GO:0008608,GO:0010212,GO:0016604,GO:0031593,GO:0031593,GO:0044818,GO:0045739,GO:0070531,GO:0070531,GO:0070536,GO:0090307 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ABRAXAS1 | hsa:84142 | path:hsa03440 | Homologous recombination - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | ABRAXAS1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | ABRAXAS1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ABRAXAS1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ABRAXAS1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ABRAXAS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ABRAXAS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ABRAXAS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ABRAXAS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ABRAXAS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001F14FE | ABRAXAS1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D4A78 | ABRAXAS1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | ABRAXAS1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003ACE11 | ABRAXAS1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ATM | ABRAXAS1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TEKT4 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| TP53BP1 | ABRAXAS1 | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RABGGTB | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| PAXIP1 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| UBC | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| PARP1 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| RAD51 | ABRAXAS1 | 17525340 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| RBBP8 | ABRAXAS1 | 17525340 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| PSMC5 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| SUMO2 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA4 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| MDC1 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| BARD1 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| BRCA1 | ABRAXAS1 | 14525934 17525340 17643121 24234451 25348397 29656893 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,fluorescence microscopy,in vitro,proximity-dependent biotin identification | ComPPI,HPRD,IntAct |
| BRIP1 | ABRAXAS1 | 17525340 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| UIMC1 | ABRAXAS1 | 14525934 17525340 19615732 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| WTAP | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| BRCC3 | ABRAXAS1 | 18077395 19615732 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BABAM2 | ABRAXAS1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BABAM1 | ABRAXAS1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LAMC1 | ABRAXAS1 | 25348397 | N/A | physical interaction | ComPPI |
| ABRAXAS1 | FANCG | 25348397 | N/A | physical interaction | ComPPI |
| ABRAXAS1 | ALDH6A1 | 25348397 | N/A | physical interaction | ComPPI |
| MANF | ABRAXAS1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| ATM | ABRAXAS1 | 26778126 27898060 | stimulant | N/A | OmniPath |
| ABRAXAS1 | BRCA1 | 17525340 17643121 17643122 19261746 19261748 19261749 19305427 19766185 21282113 22357538 23416467 25184681 27898060 | stimulant | N/A | OmniPath |