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GENE：PPP1R8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP1R8
FullNmae protein phosphatase 1 regulatory subunit 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9296
EnsembleID ENSG00000117751
Uniprot Q12972

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP1R8 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PPP1R8 GO:0003677,GO:0003723,GO:0003729,GO:0004519,GO:0004865,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005681,GO:0005737,GO:0006397,GO:0006401,GO:0008283,GO:0008380,GO:0008995,GO:0016607,GO:0016607,GO:0035308,GO:0140678

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPP1R8 LYN 11104670 23180781 physical association affinity chromatography technology InnateDB
APP PPP1R8 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 PPP1R8 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PPP1R8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PPP1R8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPP1R8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000036AFF1 PPP1R8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000017EA6A PPP1R8 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
LYN PPP1R8 22135298 phosphorylation N/A PhosphoSite
HMGA1 PPP1R8 25361965 interaction type N/A PTMCode2
PPP1R8 HMGA1 25361965 interaction type N/A PTMCode2
PPP1R8 PPP1CA 25361965 interaction type N/A PTMCode2
PPP1CA PPP1R8 25361965 interaction type N/A PTMCode2
PPP1R8 CDC5L 25361965 interaction type N/A PTMCode2
CDC5L PPP1R8 25361965 interaction type N/A PTMCode2
SF3A2 PPP1R8 25361965 interaction type N/A PTMCode2
PPP1R8 SF3A2 25361965 interaction type N/A PTMCode2
MELK PPP1R8 25361965 interaction type N/A PTMCode2
PPP1R8 MELK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC5L PPP1R8 10827081 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PPIL1 PPP1R8 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VPS4B PPP1R8 25348397 N/A physical interaction ComPPI
HSPA8 PPP1R8 25348397 N/A physical interaction ComPPI
PPP1CC PPP1R8 14525934 24234451 24366813 25348397 26496610 28330616 7499293 association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
TP53BP1 PPP1R8 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
PPP1CB PPP1R8 17353931 24234451 25348397 26496610 28330616 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
KEAP1 PPP1R8 25348397 N/A physical interaction ComPPI
APPBP2 PPP1R8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NF2 PPP1R8 25348397 N/A physical interaction ComPPI
EZH2 PPP1R8 25348397 N/A physical interaction ComPPI
SF3A2 PPP1R8 17332742 24234451 25348397 physical association affinity chromatography technology,physical interaction ComPPI,IntAct
LYN PPP1R8 11104670 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SHC1 PPP1R8 25348397 N/A physical interaction ComPPI
SETDB1 PPP1R8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R8 MELK 14525934 16216881 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP1R8 PRKACA 14525934 25348397 9407077 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPP1R8 HDAC2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PPP1R8 SF3B1 12105215 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PPP1R8 EED 12788942 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PPP1R8 CSNK2A1 14525934 25348397 9407077 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP1R8 GBP2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R8 CRMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R8 ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R8 RBM48 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R8 PPP1CA 14525934 15231748 18842582 22365833 24234451 25348397 25593058 27173435 28330616 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,pull down,x-ray crystallography,physical interaction,ion exchange chromatography,tandem affinity purification,proximity-dependent biotin identification,inference by socio-affinity scoring,two hybrid ComPPI,HPRD,IntAct
PPP1R8 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R8 STC2 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R8 SUZ12 25348397 N/A physical interaction ComPPI
PPP1R8 RBBP4 25348397 N/A physical interaction ComPPI
PPP1R8 APP 25348397 N/A physical interaction ComPPI
PPP1R8 CTNNBL1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1R8 WDR77 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1R8 HMGA1 25348397 N/A filter binding,physical interaction ComPPI
PPP1R8 FBXO25 25348397 N/A physical interaction ComPPI
PPP1R8 CYP1A1 25348397 N/A physical interaction ComPPI
PPP1R8 PPP1R3A 25348397 N/A physical interaction ComPPI
PPP1R8 DDX1 25348397 N/A physical interaction ComPPI
PPP1R8 FAM98B 25348397 N/A physical interaction ComPPI
PPP1R8 RTCB 25348397 N/A physical interaction ComPPI
PPP1R8 STXBP1 25348397 N/A physical interaction ComPPI
PPP1R8 SHMT2 25348397 N/A physical interaction ComPPI
PPP1R8 SNUPN 25348397 N/A physical interaction ComPPI
PPP1R8 USP47 25348397 N/A physical interaction ComPPI
PPP1R8 GTF2E2 25348397 N/A physical interaction ComPPI
PPP1R8 LRRK2 24234451 24510904 25348397 N/A protein array ComPPI,IntAct
CSNK2A2 PPP1R8 14525934 25348397 9407077 N/A experimental interaction detection,in vitro ComPPI,HPRD
SNRNP27 PPP1R8 25348397 N/A physical interaction ComPPI
NAT1 PPP1R8 14517307 1600941 17541948 27898060 N/A N/A OmniPath
PRKACA PPP1R8 18669648 20068231 27898060 9407077 stimulant N/A OmniPath
LCK PPP1R8 27898060 9407077 N/A N/A OmniPath
LYN PPP1R8 11104670 27898060 9407077 N/A N/A OmniPath
PPP1R8 EZH2 17804093 20671031 23241245 27898060 stimulant N/A OmniPath

Visualization










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