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GENE：PPP2R2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP2R2A
FullNmae protein phosphatase 2 regulatory subunit Balpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9304
EnsembleID ENSG00000221914
Uniprot P63151

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP2R2A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP2R2A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP2R2A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PPP2R2A GO:0000159,GO:0000159,GO:0005515,GO:0005654,GO:0005829,GO:0005829,GO:0006470,GO:0006470,GO:0019888,GO:0019888,GO:0019888,GO:0043278,GO:0098978

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP2R2A hsa:5520 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04530 Tight junction - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa05142 Chagas disease - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa05160 Hepatitis C - Homo sapiens (human)
PPP2R2A hsa:5520 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTPN1 PPP2R2A 23590304 dephosphorylation reaction,stimulation N/A SignaLink
PPP2R2A RAF1 15664191 23331499 stimulation N/A SignaLink
PPP2R2A KSR1 15664191 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
EIF4EBP1 PPP2R2A 20005715 interaction type N/A PSP
PPP2R1A PPP2R2A 20005715 interaction type N/A PSP
EIF4EBP1 PPP2R2A 16899564 20005715 20005715 21071413 N/A N/A SignaLink
PPP2R1A PPP2R2A 17540176 18988627 19156129 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PPP2R2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PPP2R2A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PPP2R2A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PPP2R2A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PPP2R2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000153377 PPP2R2A 20103675 21656127 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 PPP2R2A 20237410 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 PPP2R2A 20237410 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000153377 PPP2R2A 20103675 21656127 23622248 25416803 26701625 26800397 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,clash,miRNA interference luciferase reporter assay TarBase
URS0000338542 PPP2R2A 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000065D58 PPP2R2A 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 PPP2R2A 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 PPP2R2A 23446348 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000012930C PPP2R2A 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F PPP2R2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 PPP2R2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 PPP2R2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA PPP2R2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000008931A PPP2R2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 PPP2R2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 PPP2R2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 PPP2R2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001D6605 PPP2R2A 25416803 26297546 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000042E1F PPP2R2A 25416803 27720936 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002075FA PPP2R2A 25416803 27720936 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000060AABB PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000008A99 PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000170CF4 PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000045E0EC PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BDA4 PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000355E82 PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001012BC PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PPP2R2A 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RPS28 PPP2R2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1A PPP2R2A 14525934 15761952 17245430 17529992 17540176 17632056 18782753 19156129 19293187 19915589 20711181 24234451 25348397 26496610 27173435 28330616 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,comigration in non denaturing gel electrophoresis,tandem affinity purification,proximity-dependent biotin identification,inference by socio-affinity scoring ComPPI,HPRD,IntAct
MCM2 PPP2R2A 25348397 N/A physical interaction ComPPI
FOXC2 PPP2R2A 23878394 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIK2 PPP2R2A 16306228 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PPP4C PPP2R2A 25348397 N/A physical interaction ComPPI
NOTCH1 PPP2R2A 23022380 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PPP1R15A PPP2R2A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
GRB2 PPP2R2A 25348397 N/A physical interaction ComPPI
JUN PPP2R2A 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
AR PPP2R2A 25348397 N/A physical interaction ComPPI
ARHGEF2 PPP2R2A 24234451 24525234 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CUL3 PPP2R2A 25348397 N/A physical interaction ComPPI
GAPDH PPP2R2A 25348397 N/A physical interaction ComPPI
STRN3 PPP2R2A 10681496 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NTRK1 PPP2R2A 25348397 N/A physical interaction ComPPI
AXIN1 PPP2R2A 17510365 24234451 25348397 association tandem affinity purification ComPPI,IntAct
WWP2 PPP2R2A 25348397 N/A physical interaction ComPPI
PPP2CB PPP2R2A 18782753 19156129 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
TUBA4A PPP2R2A 25348397 N/A physical interaction ComPPI
HNRNPL PPP2R2A 25348397 N/A physical interaction ComPPI
EIF4EBP1 PPP2R2A 25348397 N/A physical interaction ComPPI
CFTR PPP2R2A 25348397 N/A physical interaction ComPPI
GRIN2D PPP2R2A 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN1 PPP2R2A 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPP2R5C PPP2R2A 25348397 N/A physical interaction ComPPI
PPP2CA PPP2R2A 1328247 14525934 18782753 19156129 19915589 20711181 24234451 25348397 26496610 28330616 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,tandem affinity purification,proximity-dependent biotin identification ComPPI,HPRD,IntAct
NDRG1 PPP2R2A 14525934 17220478 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
GRK5 PPP2R2A 25348397 N/A physical interaction ComPPI
XPO1 PPP2R2A 25348397 N/A physical interaction ComPPI
ABCE1 PPP2R2A 25348397 N/A physical interaction ComPPI
RPS6KB1 PPP2R2A 25348397 N/A physical interaction ComPPI
RPS13 PPP2R2A 24234451 25348397 28330616 association pull down ComPPI,IntAct
EGFR PPP2R2A 25348397 N/A physical interaction ComPPI
TCP1 PPP2R2A 25348397 N/A physical interaction ComPPI
CCT5 PPP2R2A 25348397 N/A physical interaction ComPPI
CCT7 PPP2R2A 25348397 N/A physical interaction ComPPI
MTREX PPP2R2A 24234451 25348397 28330616 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CHEK2 PPP2R2A 14525934 15380617 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PPP2R2A PPP2R1B 1328247 14525934 17540176 24234451 25348397 26496610 28330616 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,proximity-dependent biotin identification ComPPI,HPRD,IntAct
PPP2R2A FAM107A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R2A TCEAL1 25348397 N/A physical interaction ComPPI
PPP2R2A MTOR 25348397 N/A physical interaction ComPPI
PPP2R2A RRN3 25348397 N/A physical interaction ComPPI
PPP2R2A TGFBR1 14525934 25348397 9774674 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PPP2R2A MLH1 25348397 N/A physical interaction ComPPI
PPP2R2A PPP2R2D 24234451 25348397 28330616 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A CDCA4 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A CCT8 25348397 N/A physical interaction ComPPI
PPP2R2A CCT2 25348397 N/A physical interaction ComPPI
PPP2R2A CCT4 25348397 N/A physical interaction ComPPI
PPP2R2A CCT3 25348397 N/A physical interaction ComPPI
PPP2R2A FABP5P3 25348397 N/A physical interaction ComPPI
PPP2R2A FABP5 25348397 N/A physical interaction ComPPI
PPP2R2A DSP 25348397 N/A physical interaction ComPPI
PPP2R2A DSG1 25348397 N/A physical interaction ComPPI
PPP2R2A CCT6A 25348397 N/A physical interaction ComPPI
PPP2R2A HDAC5 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R2A ELAVL1 25348397 N/A physical interaction ComPPI
PPP2R2A PTPN14 25348397 N/A physical interaction ComPPI
PPP2R2A SMURF1 25348397 N/A physical interaction ComPPI
PPP2R2A CDK17 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PPP2R2A CDK16 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PPP2R2A LATS2 25348397 N/A physical interaction ComPPI
PPP2R2A HSPA4L 25348397 N/A physical interaction ComPPI
PPP2R2A NRDC 25348397 N/A physical interaction ComPPI
PPP2R2A PPP3CA 25348397 N/A physical interaction ComPPI
PPP2R2A THUMPD1 25348397 N/A physical interaction ComPPI
PPP2R2A PABIR1 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PPP2R2A SERTAD4 24234451 25348397 28330616 association pull down,physical interaction ComPPI,IntAct
PPP2R2A IER2 25348397 N/A physical interaction ComPPI
PPP2R2A RPS6KB2 25348397 N/A physical interaction ComPPI
PPP2R2A NCAPD3 25348397 N/A physical interaction ComPPI
PPP2R2A WDR4 25348397 N/A physical interaction ComPPI
PPP2R2A AHI1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A PPME1 24234451 25348397 28330616 association pull down,physical interaction ComPPI,IntAct
PPP2R2A FOXC1 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PPP2R2A GC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R2A YARS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R2A RBM7 24234451 25348397 28330616 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A RAB11FIP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R2A ECSIT 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PPP2R2A FBXL16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R2A CRY2 25348397 N/A physical interaction ComPPI
PPP2R2A NOSIP 25348397 N/A physical interaction ComPPI
PPP2R2A C1ORF131 25348397 N/A physical interaction ComPPI
PPP2R2A DERL1 25348397 N/A physical interaction ComPPI
PPP2R2A DUSP19 25348397 N/A physical interaction ComPPI
PPP2R2A PHLPP1 25348397 N/A physical interaction ComPPI
PPP2R2A PTPDC1 25348397 N/A physical interaction ComPPI
PPP2R2A FOXD4 25348397 N/A physical interaction ComPPI
PPP2R2A TAFA3 25348397 N/A physical interaction ComPPI
PPP2R2A UBE2A 25348397 N/A physical interaction ComPPI
PPP2R2A TP53 17245430 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PPP2R2A DAPK1 20220139 24234451 25348397 association,physical association anti tag coimmunoprecipitation,rna interference ComPPI,IntAct
PPP2R2A ANKLE2 22770216 24234451 25348397 27898060 association pull down ComPPI,IntAct,OmniPath
PPP2R2A KSR1 24234451 24525234 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R2A ENSA 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R2A IER5 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R2A RPS11 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A CCAR2 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A NDUFAF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R2A PPP2R2C 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R2A ZCCHC8 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A PPP2R2B 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R2A ACLY 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
PPP2R2A S100A7 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R2A S100A9 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R2A S100A8 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R5D PPP2R2A 25348397 N/A physical interaction ComPPI
CACNA1S PPP2R2A 25348397 N/A physical interaction ComPPI
PARP1 PPP2R2A 24234451 30021884 physical association cross-linking study IntAct
TGFB1 PPP2R2A 19114990 27898060 stimulant N/A OmniPath
PPP2R2A RAF1 16239230 27898060 stimulant N/A OmniPath
PPP2R2A PPP2CA 1328247 18782753 19114990 19156129 22939629 26344197 26496610 27898060 inhibition N/A OmniPath
PPP2R2A TGFBR1 27898060 9774674 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B9FE8 PPP2R2A 27087310 direct interaction,inhibition N/A NPInter

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