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GENE：RB1CC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RB1CC1
FullNmae RB1 inducible coiled-coil 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15574
EnsembleID ENSG00000023287
Uniprot Q8TDY2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RB1CC1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RB1CC1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RB1CC1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
RB1CC1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RB1CC1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RB1CC1 GO:0000045,GO:0000045,GO:0000407,GO:0000421,GO:0000422,GO:0001889,GO:0001934,GO:0005515,GO:0005764,GO:0005789,GO:0005829,GO:0005829,GO:0006914,GO:0007049,GO:0007507,GO:0008285,GO:0010508,GO:0019901,GO:0019901,GO:0030242,GO:0031965,GO:0034045,GO:0034045,GO:0034727,GO:0045793,GO:0046330,GO:0060090,GO:0061709,GO:0061723,GO:0097191,GO:1903059,GO:1990316,GO:1990316,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RB1CC1 hsa:9821 path:hsa04140 Autophagy - animal - Homo sapiens (human)
RB1CC1 hsa:9821 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
RB1CC1 hsa:9821 path:hsa05010 Alzheimer disease - Homo sapiens (human)
RB1CC1 hsa:9821 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
RB1CC1 hsa:9821 path:hsa05016 Huntington disease - Homo sapiens (human)
RB1CC1 hsa:9821 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
RB1CC1 hsa:9821 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RB1CC1 TSC1 16043512 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
RB1CC1 TSC2 16043512 23180781 physical association anti tag coimmunoprecipitation InnateDB
ULK1 RB1CC1 19211835 19225151 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
RB1CC1 ATG13 19225151 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
ATG101 RB1CC1 19597335 23180781 physical association anti tag coimmunoprecipitation InnateDB
RB1CC1 PTK2 12221124 23180781 physical association anti tag coimmunoprecipitation InnateDB
RB1CC1 RB1 19437535 23180781 physical association anti tag coimmunoprecipitation InnateDB
RB1CC1 TP53 16061648 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
RB1CC1 ULK1 19225151 20562859 23180781 physical association anti tag coimmunoprecipitation InnateDB
RB1CC1 ULK2 19225151 23180781 physical association anti tag coimmunoprecipitation InnateDB
ULK2 RB1CC1 19225151 23180781 physical association pull down InnateDB
TBKBP1 RB1CC1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 RB1CC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RB1CC1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RB1CC1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 RB1CC1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RB1CC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000032BD73 RB1CC1 23451058 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000032BD73 RB1CC1 23451058 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000ED600 RB1CC1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 RB1CC1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AA464 RB1CC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F RB1CC1 25416803 26829385 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002B3783 RB1CC1 25416803 26829385 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000184017 RB1CC1 25416803 26536662 27615604 mrna cleavage,inhibition experimental interaction detection,western blot,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
RB1CC1 ULK1 25361965 interaction type N/A PTMCode2
ULK1 RB1CC1 25361965 interaction type N/A PTMCode2
RB1CC1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 RB1CC1 25361965 interaction type N/A PTMCode2
RB1CC1 ULK2 25361965 interaction type N/A PTMCode2
ULK2 RB1CC1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
WASHC3 RB1CC1 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAA2 RB1CC1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSBP1 RB1CC1 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SGTB RB1CC1 25348397 N/A physical interaction ComPPI
SKIL RB1CC1 25348397 N/A physical interaction ComPPI
WIF1 RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAP1LC3B RB1CC1 24234451 24290141 25348397 association pull down,physical interaction ComPPI,IntAct
ERRFI1 RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTK2B RB1CC1 10769033 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RNF111 RB1CC1 25348397 N/A physical interaction ComPPI
COP1 RB1CC1 25348397 N/A physical interaction ComPPI
VAPA RB1CC1 25348397 N/A physical interaction ComPPI
SYN1 RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
POLR1E RB1CC1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBC RB1CC1 25348397 N/A physical interaction ComPPI
CDH1 RB1CC1 25348397 N/A physical interaction ComPPI
RPA1 RB1CC1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLK1 RB1CC1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP3K5 RB1CC1 25348397 N/A physical interaction ComPPI
DBNL RB1CC1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HBP1 RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EXOC1 RB1CC1 25348397 N/A physical interaction ComPPI
RPA2 RB1CC1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCB1 RB1CC1 20614030 21637919 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRAF1 RB1CC1 25348397 N/A physical interaction ComPPI
TRAF2 RB1CC1 25348397 N/A physical interaction ComPPI
PSMC3IP RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HUWE1 RB1CC1 25348397 N/A physical interaction ComPPI
HNRNPA2B1 RB1CC1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VAPB RB1CC1 25348397 N/A physical interaction ComPPI
VHL RB1CC1 25348397 N/A two hybrid,physical interaction ComPPI
GABARAP RB1CC1 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DLG3 RB1CC1 25348397 N/A physical interaction ComPPI
CTNNB1 RB1CC1 22751121 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP1LC3A RB1CC1 25348397 N/A pull down,physical interaction ComPPI
MADD RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBMX RB1CC1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM25 RB1CC1 25348397 N/A physical interaction ComPPI
TBK1 RB1CC1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 ERCC6L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 CDK19 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 MOB4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 PTK2 25348397 N/A physical interaction ComPPI
RB1CC1 ATG13 19597335 20562859 23392225 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
RB1CC1 MAP1LC3C 20562859 24234451 24290141 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
RB1CC1 PRKAB2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 SMCR8 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 ATG101 19597335 20562859 23392225 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
RB1CC1 SAFB2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 SAFB 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 YLPM1 25348397 N/A physical interaction ComPPI
RB1CC1 ULK1 20562859 23392225 23524951 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
RB1CC1 ULK2 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 TP53 21775823 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 TBKBP1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 SKI 25348397 N/A physical interaction ComPPI
RB1CC1 GABARAPL1 25348397 N/A physical interaction ComPPI
RB1CC1 PINK1 25348397 N/A physical interaction ComPPI
RB1CC1 CALCOCO2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RB1CC1 DYRK2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RB1CC1 ATG16L1 20562859 23262492 23392225 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
RB1CC1 ATG5 23262492 23392225 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
RB1CC1 SESN2 24234451 25040165 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1CC1 CCDC8 25348397 N/A physical interaction ComPPI
RB1CC1 BAP1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 BLID 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 EPSTI1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 GLCE 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 GREB1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 IL13RA2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 IL24 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 ITIH5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 LYPD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 MRC2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 VPS45 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 NSD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 UMPS 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 TACC1 25348397 N/A physical interaction ComPPI
RB1CC1 TCEAL4 25348397 N/A physical interaction ComPPI
RB1CC1 SGO1 25348397 N/A physical interaction ComPPI
RB1CC1 NANOGP8 25348397 N/A physical interaction ComPPI
RB1CC1 NANOG 25348397 N/A physical interaction ComPPI
RB1CC1 MTMR4 25348397 N/A physical interaction ComPPI
RB1CC1 DUSP29 25348397 N/A physical interaction ComPPI
RB1CC1 FAM221B 25348397 N/A physical interaction ComPPI
RB1CC1 DENR 25348397 N/A physical interaction ComPPI
RB1CC1 ATG12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RB1CC1 TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RB1CC1 LONP2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 NFS1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 TRIM33 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 MAP4 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 SH3GL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 C9ORF72 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 WDR41 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 TBC1D32 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 WIPI2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RNF20 RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SYCE3 RB1CC1 25348397 N/A physical interaction ComPPI
THRSP RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1CC1 RB1CC1 20562859 24234451 association,physical association anti tag coimmunoprecipitation IntAct
HSP90B1 RB1CC1 24234451 30021884 physical association cross-linking study IntAct
ULK1 RB1CC1 18443221 18981720 19211835 19225151 19258318 19597335 20562859 25686248 27898060 stimulant N/A OmniPath
RB1CC1 ULK1 18443221 18981720 19211835 19225151 19258318 20562859 25686248 27898060 stimulant N/A OmniPath
ATG13 RB1CC1 19211835 19225151 19597335 20562859 27898060 stimulant N/A OmniPath
RB1CC1 PTK2 10769033 12221124 27898060 N/A N/A OmniPath
RB1CC1 ATG16L1 20562859 23262492 23392225 24100292 24954904 27898060 stimulant N/A OmniPath
RB1CC1 TP53 16061648 21775823 27898060 stimulant N/A OmniPath
ULK2 RB1CC1 19225151 20562859 27898060 stimulant N/A OmniPath
RB1CC1 ULK2 18936157 19225151 27898060 stimulant N/A OmniPath
RB1CC1 TSC1 16043512 27898060 inhibition N/A OmniPath
TBKBP1 RB1CC1 21903422 27898060 N/A N/A OmniPath
RB1CC1 PTK2B 10769033 27898060 inhibition N/A OmniPath

Visualization










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