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GENE：GNB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GNB2
FullNmae G protein subunit beta 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4398
EnsembleID ENSG00000172354
Uniprot P62879

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GNB2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GNB2 GO:0003924,GO:0005515,GO:0005615,GO:0005737,GO:0005765,GO:0005829,GO:0005834,GO:0005886,GO:0005925,GO:0007186,GO:0016020,GO:0030159,GO:0031982,GO:0044877,GO:0048471,GO:0051020,GO:0070062,GO:1901379

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GNB2 hsa:2783 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04713 Circadian entrainment - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04727 GABAergic synapse - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
GNB2 hsa:2783 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
GNB2 hsa:2783 path:hsa05032 Morphine addiction - Homo sapiens (human)
GNB2 hsa:2783 path:hsa05034 Alcoholism - Homo sapiens (human)
GNB2 hsa:2783 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
GNB2 hsa:2783 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
GNB2 hsa:2783 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
GNB2 hsa:2783 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GNG4 GNB2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
E2F4 GNB2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 GNB2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GNB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GNB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GNB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GNB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GNB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE GNB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 GNB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE GNB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D GNB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC GNB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC864 GNB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E0AEA GNB2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000419B5A GNB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C3AC1 GNB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC GNB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000057FDB8 GNB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F GNB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000002103A GNB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE GNB2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GNAI3 GNB2 25348397 N/A physical interaction ComPPI
GNG5 GNB2 14525934 25348397 8636150 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GNGT1 GNB2 14525934 25348397 8636150 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GNG10 GNB2 25348397 N/A physical interaction,in vitro ComPPI
ANXA1 GNB2 25348397 N/A physical interaction ComPPI
PCBP1 GNB2 11591653 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CDKN1A GNB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BMP7 GNB2 25348397 N/A physical interaction ComPPI
STAT1 GNB2 25348397 N/A physical interaction ComPPI
TRAF6 GNB2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TINAGL1 GNB2 25348397 N/A physical interaction ComPPI
VBP1 GNB2 25348397 N/A physical interaction ComPPI
PFDN4 GNB2 25348397 N/A physical interaction ComPPI
H4C1 GNB2 25348397 N/A physical interaction ComPPI
GRB7 GNB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ERBB2 GNB2 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TBP GNB2 25348397 N/A physical interaction ComPPI
CD81 GNB2 24234451 25348397 30024968 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
RHOC GNB2 25348397 N/A physical interaction ComPPI
FLNA GNB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRN GNB2 25348397 N/A physical interaction ComPPI
GSK3B GNB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CLU GNB2 25348397 N/A physical interaction ComPPI
ACTN4 GNB2 25348397 N/A physical interaction ComPPI
RAB7A GNB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBG1 GNB2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GNAQ GNB2 25348397 N/A physical interaction ComPPI
RASD2 GNB2 25348397 N/A physical interaction ComPPI
UBC GNB2 25348397 N/A physical interaction ComPPI
CANX GNB2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LRP1 GNB2 25348397 N/A physical interaction ComPPI
STAT5A GNB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NFATC2 GNB2 25348397 N/A physical interaction ComPPI
PDHB GNB2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RCC1 GNB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
H2BC21 GNB2 25348397 N/A physical interaction ComPPI
XPO1 GNB2 25348397 N/A physical interaction ComPPI
GRK2 GNB2 25348397 N/A physical interaction ComPPI
CDK2 GNB2 25348397 N/A physical interaction ComPPI
ID3 GNB2 25348397 N/A physical interaction ComPPI
ADRB2 GNB2 25348397 N/A physical interaction ComPPI
CUL4A GNB2 25348397 N/A physical interaction ComPPI
CACNA1A GNB2 25348397 N/A physical interaction ComPPI
EGFR GNB2 25348397 N/A physical interaction ComPPI
CD27 GNB2 25348397 N/A physical interaction ComPPI
HTT GNB2 17500595 24234451 25348397 association pull down ComPPI,IntAct
TCP1 GNB2 25348397 N/A physical interaction ComPPI
POLR3E GNB2 25348397 N/A physical interaction ComPPI
RAF1 GNB2 14525934 25348397 7782277 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MEF2A GNB2 25348397 N/A physical interaction ComPPI
PFDN5 GNB2 25348397 N/A physical interaction ComPPI
RIPK3 GNB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP2B1 GNB2 25348397 N/A physical interaction ComPPI
SLC4A8 GNB2 25348397 N/A physical interaction ComPPI
NR3C1 GNB2 25348397 N/A physical interaction ComPPI
HDAC5 GNB2 25348397 N/A physical interaction ComPPI
GNG2 GNB2 25348397 N/A physical interaction ComPPI
HTR2C GNB2 25348397 N/A physical interaction ComPPI
TAF8 GNB2 25348397 N/A physical interaction ComPPI
SVIL GNB2 12202484 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PDCL GNB2 25348397 N/A physical interaction ComPPI
GNA11 GNB2 25348397 N/A physical interaction ComPPI
GNAS GNB2 25348397 N/A physical interaction ComPPI
IL27RA GNB2 25348397 N/A physical interaction ComPPI
GDF9 GNB2 25348397 N/A physical interaction ComPPI
DDB1 GNB2 25348397 N/A physical interaction ComPPI
CACNA1B GNB2 25348397 N/A physical interaction ComPPI
CACNA1E GNB2 25348397 N/A physical interaction ComPPI
ESR1 GNB2 21182205 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
GNB2 GNG7 14525934 25348397 8308009 8636150 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
GNB2 GNG13 11675383 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GNB2 ATXN10 14525934 16498633 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
GNB2 GNG3 14525934 25348397 8636150 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GNB2 FANCA 25348397 N/A physical interaction ComPPI
GNB2 USP50 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GNB2 ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GNB2 TSC22D1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GNB2 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GNB2 RGS6 25348397 N/A physical interaction ComPPI
GNB2 GNG8 25348397 N/A physical interaction ComPPI
GNB2 GNAI1 25348397 N/A physical interaction ComPPI
GNB2 GNAI2 25348397 N/A physical interaction ComPPI
GNB2 PAN2 25348397 N/A physical interaction ComPPI
GNB2 CSNK1A1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GNB2 MTOR 25348397 N/A physical interaction ComPPI
GNB2 STAT3 25348397 N/A physical interaction ComPPI
GNB2 TP53 25348397 N/A physical interaction ComPPI
GNB2 HMOX2 25348397 N/A physical interaction ComPPI
GNB2 POMK 25348397 N/A physical interaction ComPPI
GNB2 GNAS 25348397 N/A physical interaction ComPPI
GNB2 GNAS 25348397 N/A physical interaction ComPPI
GNB2 SGO2 25348397 N/A physical interaction ComPPI
GNB2 CHIA 25348397 N/A physical interaction ComPPI
GNB2 SP6 25348397 N/A physical interaction ComPPI
GNB2 WRAP73 25348397 N/A physical interaction ComPPI
GNB2 CDK13 25348397 N/A physical interaction ComPPI
GNB2 ATP6V0D1 25348397 N/A physical interaction ComPPI
GNB2 NDUFS1 25348397 N/A physical interaction ComPPI
GNB2 PC 25348397 N/A physical interaction ComPPI
GNB2 DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GNB2 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GNB2 SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GNB2 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GNB2 ESRRB 25348397 N/A physical interaction ComPPI
GNB2 EYA2 25348397 N/A physical interaction ComPPI
GNB2 MTMR7 25348397 N/A physical interaction ComPPI
GNB2 SLC6A5 25348397 N/A physical interaction ComPPI
GNB2 NTRK3 25348397 N/A physical interaction ComPPI
GNB2 DEFB104A 25348397 N/A physical interaction ComPPI
GNB2 PRAMEF17 25348397 N/A physical interaction ComPPI
GNB2 PACC1 25348397 N/A physical interaction ComPPI
GNB2 PFDN1 25348397 N/A physical interaction ComPPI
GNB2 KCNJ5 25348397 N/A physical interaction ComPPI
GNB2 ZNF517 25348397 N/A physical interaction ComPPI
GNB2 ADAM21 25348397 N/A physical interaction ComPPI
GNB2 IGFBP1 25348397 N/A physical interaction ComPPI
GNB2 PFDN6 25348397 N/A physical interaction ComPPI
GNB2 CYP8B1 25348397 N/A physical interaction ComPPI
GNB2 ACSF2 25348397 N/A physical interaction ComPPI
GNB2 CPLX3 25348397 N/A physical interaction ComPPI
GNB2 TCTN1 25348397 N/A physical interaction ComPPI
GNB2 CCT2 25348397 N/A physical interaction ComPPI
GNB2 MMP26 25348397 N/A physical interaction ComPPI
GNB2 ANGPTL7 25348397 N/A physical interaction ComPPI
GNB2 CCT3 25348397 N/A physical interaction ComPPI
GNB2 CBLN4 25348397 N/A physical interaction ComPPI
GNB2 TXNDC9 25348397 N/A physical interaction ComPPI
GNB2 GALK2 25348397 N/A physical interaction ComPPI
GNB2 ADGRE5 25348397 N/A physical interaction ComPPI
GNB2 TMPRSS12 25348397 N/A physical interaction ComPPI
GNB2 PLA2G10 25348397 N/A physical interaction ComPPI
GNB2 TARDBP 25348397 N/A physical interaction ComPPI
GNB2 SERINC1 25348397 N/A physical interaction ComPPI
GNB2 CTSE 25348397 N/A physical interaction ComPPI
GNB2 CCT4 25348397 N/A physical interaction ComPPI
GNB2 SCMH1 25348397 N/A physical interaction ComPPI
GNB2 SLC29A1 25348397 N/A physical interaction ComPPI
GNB2 ASB6 25348397 N/A physical interaction ComPPI
GNB2 FMO2 25348397 N/A physical interaction ComPPI
GNB2 EIF3L 25348397 N/A physical interaction ComPPI
GNB2 CCT6A 25348397 N/A physical interaction ComPPI
GNB2 GBP1 25348397 N/A physical interaction ComPPI
GNB2 FBXL14 25348397 N/A physical interaction ComPPI
GNB2 NAT16 25348397 N/A physical interaction ComPPI
GNB2 CCT6B 25348397 N/A physical interaction ComPPI
GNB2 MTNR1B 17215244 24234451 25348397 26514267 association physical interaction,tandem affinity purification ComPPI,IntAct
GNB2 G3BP1 25348397 N/A physical interaction ComPPI
GNB2 MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GNB2 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GNB2 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
GNB2 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CAPNS1 GNB2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GNG12 GNB2 10409705 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ATF2 GNB2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GNG4 GNB2 14525934 16884933 25348397 7665596 8636150 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SHBG GNB2 25348397 N/A physical interaction ComPPI
PMM1 GNB2 25348397 N/A physical interaction ComPPI
AKR7A3 GNB2 25348397 N/A physical interaction ComPPI
FAM118B GNB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GNB2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
L1TD1 GNB2 24234451 25702638 association anti bait coimmunoprecipitation IntAct
SMO GNB2 16885213 23074268 27898060 stimulant N/A OmniPath

Visualization










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