GENE：SLC18A2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC18A2 |
| FullNmae | solute carrier family 18 member A2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10935 |
| EnsembleID | ENSG00000165646 |
| Uniprot | Q05940 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC18A2 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC18A2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC18A2 | GO:0001975,GO:0002552,GO:0002553,GO:0005335,GO:0005515,GO:0005813,GO:0005886,GO:0006836,GO:0007268,GO:0007626,GO:0008021,GO:0008504,GO:0009636,GO:0009791,GO:0015311,GO:0015842,GO:0015844,GO:0015872,GO:0016020,GO:0030424,GO:0030425,GO:0030667,GO:0030672,GO:0030672,GO:0042137,GO:0043195,GO:0043231,GO:0051610,GO:0051615,GO:0070083,GO:0098691,GO:0098700,GO:0099123,GO:1902600,GO:1903427 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC18A2 | hsa:6571 | path:hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
| SLC18A2 | hsa:6571 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| SLC18A2 | hsa:6571 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| SLC18A2 | hsa:6571 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| SLC18A2 | hsa:6571 | path:hsa05030 | Cocaine addiction - Homo sapiens (human) |
| SLC18A2 | hsa:6571 | path:hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| SLC18A2 | hsa:6571 | path:hsa05034 | Alcoholism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | SLC18A2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLC18A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC18A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC18A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC18A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC18A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKCA | SLC18A2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SLC7A1 | SLC18A2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CSNK2A1 | SLC18A2 | 14525934 25348397 9045708 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CXCR2 | SLC18A2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CSNK2A2 | SLC18A2 | 14525934 25348397 9045708 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SLC18A2 | PARK7 | 22554508 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| SLC18A2 | TMEM109 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLC18A2 | CFHR5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLC18A2 | TOMM6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLC18A2 | MFSD5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKG7 | SLC18A2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CSNK1A1 | SLC18A2 | 14525934 9045708 | N/A | experimental interaction detection | HPRD |
| PRKCA | SLC18A2 | 24321511 27898060 | N/A | N/A | OmniPath |
| CSNK1A1 | SLC18A2 | 18088087 27898060 9045708 | N/A | N/A | OmniPath |
| MAPK3 | SLC18A2 | 27898060 9045708 | N/A | N/A | OmniPath |
| CSNK2A1 | SLC18A2 | 18088087 27898060 9045708 | N/A | N/A | OmniPath |
| CSNK2A2 | SLC18A2 | 18088087 27898060 9045708 | N/A | N/A | OmniPath |