Gene Information gene info

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GENE：FECH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FECH
FullNmae ferrochelatase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3647
EnsembleID ENSG00000066926
Uniprot P22830

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FECH autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FECH GO:0004325,GO:0004325,GO:0005515,GO:0005739,GO:0005743,GO:0005759,GO:0006091,GO:0006783,GO:0006783,GO:0008198,GO:0008203,GO:0009410,GO:0009416,GO:0009589,GO:0010288,GO:0010999,GO:0017085,GO:0020037,GO:0030218,GO:0030350,GO:0034379,GO:0042803,GO:0045471,GO:0046501,GO:0046685,GO:0046984,GO:0051537,GO:0051597,GO:0060586,GO:0070541,GO:0071549

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FECH hsa:2235 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)
FECH hsa:2235 path:hsa01100 Metabolic pathways - Homo sapiens (human)
FECH hsa:2235 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR2 FECH 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 FECH 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FECH 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FECH 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC FECH 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 FECH 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FECH 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000FC8EB FECH 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 FECH 23622248 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS0000065FDF FECH 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 FECH 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 FECH 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 FECH 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
USP20 FECH 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATPAF2 FECH 25348397 N/A physical interaction ComPPI
PPP2R1A FECH 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CALM1 FECH 25348397 N/A physical interaction,inference by socio-affinity scoring ComPPI
COPS5 FECH 25348397 N/A physical interaction ComPPI
NELFB FECH 25348397 N/A physical interaction ComPPI
CUL3 FECH 25348397 N/A physical interaction ComPPI
PPP2CB FECH 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NELFCD FECH 25348397 N/A physical interaction ComPPI
HNRNPL FECH 25348397 N/A physical interaction ComPPI
PPP2CA FECH 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FECH MME 17342744 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FECH ELAVL1 25348397 N/A physical interaction ComPPI
FECH COPS6 25348397 N/A physical interaction ComPPI
FECH FBXO6 25348397 N/A physical interaction ComPPI
FECH TIMP2 25348397 N/A physical interaction ComPPI
FECH ATM 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FECH POU5F1 25348397 N/A physical interaction ComPPI
FECH HSPD1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FECH NELFE 25348397 N/A physical interaction ComPPI
FECH TMOD3 25348397 N/A physical interaction ComPPI
FECH PDK2 25348397 N/A physical interaction ComPPI
FECH GNA15 25348397 N/A physical interaction ComPPI
FECH PGRMC1 24234451 25348397 27599036 enzymatic reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,enzymatic study ComPPI,IntAct
FECH SIRT3 25348397 N/A physical interaction ComPPI
FECH MCCC1 25348397 N/A physical interaction ComPPI
FECH RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
FECH CLPP 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
FECH COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
FECH CALM2 24234451 physical association inference by socio-affinity scoring IntAct

Visualization










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