GENE：FRS2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FRS2 |
| FullNmae | fibroblast growth factor receptor substrate 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16971 |
| EnsembleID | ENSG00000166225 |
| Uniprot | Q8WU20 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FRS2 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FRS2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FRS2 | GO:0001702,GO:0001759,GO:0003281,GO:0005068,GO:0005068,GO:0005104,GO:0005104,GO:0005168,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0007185,GO:0007186,GO:0007405,GO:0008543,GO:0008543,GO:0008543,GO:0008595,GO:0012505,GO:0016020,GO:0019211,GO:0030900,GO:0042981,GO:0043410,GO:0046619,GO:0050678,GO:0060527,GO:0070307,GO:0070372,GO:1904707,GO:2000726 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FRS2 | hsa:10818 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| FRS2 | hsa:10818 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| FRS2 | hsa:10818 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FRS2 | PTPN11 | 11447289 17673906 23331499 25772309 26192618 9632781 | interaction type,stimulation | N/A | ACSN,SignaLink |
| FGFR1 | FRS2 | 12767520 17496910 17673906 23331499 25467007 26192618 9660748 | interaction type,stimulation | N/A | ACSN,SignaLink,SignaLink |
| FGFR2 | FRS2 | 17496910 26192618 | interaction type | N/A | ACSN |
| FGFR3 | FRS2 | 12767520 17496910 17673906 26192618 | interaction type | N/A | ACSN |
| GRB2 | FRS2 | 10086337 10567412 10811803 10982827 11274345 11447289 11777939 11997436 12040186 12175651 12640133 14585353 15173823 15567848 15574420 15863030 16102570 16488589 16582911 16887996 17496910 17673906 19449109 19568798 24027568 25772309 26192618 26552706 6321473 7510700 8551221 | interaction type | N/A | ACSN |
| SPRY2 | FRS2 | 11447289 11997436 15173823 17496910 26192618 | interaction type | N/A | ACSN |
| SPRY1 | FRS2 | 11447289 11997436 15173823 17496910 26192618 | interaction type | N/A | ACSN |
| NTRK1 | FRS2 | 10092678 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| RET | FRS2 | 11360177 11390647 23331499 | stimulation | N/A | SignaLink |
| FRS2 | GRAP | 11997436 23331499 | stimulation | N/A | SignaLink |
| FRS2 | CBL | 11997436 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FRS2 | NTRK1 | 10092678 18988627 20005715 | interaction type | N/A | PSP,SignaLink |
| FRS2 | INSR | 20005715 | interaction type | N/A | PSP |
| FRS2 | RET | 20005715 | interaction type | N/A | PSP |
| FRS2 | PTPRF | 10822386 18988627 20005715 | interaction type | N/A | PSP,SignaLink |
| FRS2 | FGFR1 | 20005715 | interaction type | N/A | PSP |
| FRS2 | SRC | 20005715 | interaction type | N/A | PSP |
| FRS2 | CBL | 20005715 | interaction type | N/A | PSP,SignaLink |
| FRS2 | MAPK1 | 20005715 | interaction type | N/A | PSP |
| FRS2 | KDR | 12154000 18988627 20005715 | interaction type | N/A | PSP,SignaLink |
| FRS2 | PRKCI | 20005715 | interaction type | N/A | PSP |
| FRS2 | PRKCZ | 20005715 | interaction type | N/A | PSP |
| FRS2 | PTPN11 | 20005715 | interaction type | N/A | PSP |
| FRS2 | PAK1 | 20005715 | interaction type | N/A | PSP,SignaLink |
| FRS2 | NTRK3 | 20005715 | interaction type | N/A | PSP,SignaLink |
| FRS2 | NTRK2 | 20005715 | interaction type | N/A | PSP |
| FRS2 | RND1 | 15738000 18988627 20005715 | interaction type | N/A | PSP,SignaLink |
| FRS2 | PRKCZ | 10383403 18988627 20005715 | N/A | N/A | SignaLink |
| FRS2 | SRC | 20005715 | N/A | N/A | SignaLink |
| FRS2 | FGFR1 | 10629055 11090629 11090629 11877385 20005715 20005715 21071413 9660748 9660748 | N/A | N/A | SignaLink |
| FRS2 | INSR | 10650943 10650943 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| FRS2 | MAPK1 | 20005715 20005715 | N/A | N/A | SignaLink |
| FRS2 | NTRK2 | 20005715 20005715 | N/A | N/A | SignaLink |
| FRS2 | PRKCI | 10383403 10383403 10383403 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| FRS2 | PTPN11 | 20005715 20005715 | N/A | N/A | SignaLink |
| FRS2 | RET | 11360177 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | FRS2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | FRS2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | FRS2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | FRS2 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | FRS2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | FRS2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FRS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FRS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FRS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FRS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FRS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FRS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | FRS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000039A25B | FRS2 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS000021D7C8 | FRS2 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS000016FF9C | FRS2 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000DDD35 | FRS2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS000032FC1A | FRS2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000034B6F5 | FRS2 | 24855559 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr | TarBase |
| URS0000007FBA | FRS2 | 21572407 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CCD18 | FRS2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | FRS2 | 21572407 22100165 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040828B | FRS2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | FRS2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | FRS2 | 21572407 23446348 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | FRS2 | 23446348 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | FRS2 | 21572407 23446348 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001EB3 | FRS2 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000544FF1 | FRS2 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EEE35 | FRS2 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B9F58 | FRS2 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016D2D4 | FRS2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272039 | FRS2 | 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009262D | FRS2 | 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000036B845 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070CD2 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000042619A | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003575B | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005606AA | FRS2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C4762 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | FRS2 | 21572407 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F9A0F | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012A1DD | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000055BBE5 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171525 | FRS2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075994C | FRS2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NCK1 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | NCK1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK1 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | MAPK1 | 25361965 | interaction type | N/A | PTMCode2 |
| KDR | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | KDR | 25361965 | interaction type | N/A | PTMCode2 |
| CBL | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | CBL | 25361965 | interaction type | N/A | PTMCode2 |
| GAB1 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | GAB1 | 25361965 | interaction type | N/A | PTMCode2 |
| NTRK2 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | NTRK2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | CRK | 25361965 | interaction type | N/A | PTMCode2 |
| CRK | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | RND1 | 25361965 | interaction type | N/A | PTMCode2 |
| RND1 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | RET | 25361965 | interaction type | N/A | PTMCode2 |
| RET | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | SRC | 25361965 | interaction type | N/A | PTMCode2 |
| SRC | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | NTRK3 | 25361965 | interaction type | N/A | PTMCode2 |
| NTRK3 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | FGFR1 | 25361965 | interaction type | N/A | PTMCode2 |
| FGFR1 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| FRS2 | SOS1 | 25361965 | interaction type | N/A | PTMCode2 |
| SOS1 | FRS2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SPRY2 | FRS2 | 25348397 | N/A | physical interaction | ComPPI |
| CRK | FRS2 | 10092678 12154000 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PAK1 | FRS2 | 25348397 | N/A | in vitro | ComPPI |
| CBL | FRS2 | 11997436 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| MAPK1 | FRS2 | 12419216 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| LYN | FRS2 | 25348397 | N/A | physical interaction | ComPPI |
| PTPN11 | FRS2 | 11447289 14525934 24234451 25348397 29997244 9632781 | association,physical association | bioluminescence resonance energy transfer,coimmunoprecipitation,experimental interaction detection,far western blotting,physical interaction,in vitro,in vivo,luminescence based mammalian interactome mapping | ComPPI,HPRD,IntAct |
| SRC | FRS2 | 10092678 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| KDR | FRS2 | 12154000 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SOS1 | FRS2 | 14525934 25348397 9182757 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| NCK1 | FRS2 | 12154000 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GAB2 | FRS2 | 25348397 | N/A | physical interaction | ComPPI |
| GRB2 | FRS2 | 11997436 12402043 14525934 21706016 24234451 25348397 8780727 9182757 | association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| FGFR2 | FRS2 | 25348397 | N/A | physical interaction | ComPPI |
| SORBS1 | FRS2 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | PRKCZ | 10383403 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| FRS2 | PTPRF | 10822386 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| FRS2 | NTRK1 | 10092678 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| FRS2 | DDR1 | 10783152 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| FRS2 | RND1 | 14525934 15738000 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| FRS2 | FGFR1 | 21765395 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| FRS2 | INSR | 10650943 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| FRS2 | RET | 11360177 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| FRS2 | NTRK2 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | NTRK3 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | FLOT1 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | BECN1 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| FRS2 | RPS6 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| FRS2 | TMEM17 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| FRS2 | CDH1 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | SH2B1 | 24234451 24396070 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| GAB1 | FRS2 | 11353842 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| PRKCI | FRS2 | 10383403 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| NTRK1 | FRS2 | 10092678 27898060 | stimulant | N/A | OmniPath |
| FGFR1 | FRS2 | 10629055 11090629 11877385 21765395 27898060 9632781 9660748 | stimulant | N/A | OmniPath |
| RET | FRS2 | 11360177 1136018 11390647 27898060 | stimulant | N/A | OmniPath |
| CBL | FRS2 | 11997436 17944804 27898060 | inhibition | N/A | OmniPath |
| FRS2 | CBL | 11997436 17944804 27898060 | stimulant | N/A | OmniPath |
| PTPN11 | FRS2 | 10650943 11360177 11447289 22974441 27898060 9632781 | stimulant | N/A | OmniPath |
| FRS2 | PTPN11 | 10650943 11360177 11447289 22974441 27898060 9632781 | stimulant | N/A | OmniPath |
| FRS2 | GRAP | 11997436 27898060 | stimulant | N/A | OmniPath |