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GENE：HEXIM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HEXIM1
FullNmae HEXIM P-TEFb complex subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24953
EnsembleID ENSG00000186834
Uniprot O94992

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HEXIM1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HEXIM1 GO:0000122,GO:0000122,GO:0000122,GO:0002218,GO:0004860,GO:0004861,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0007507,GO:0017069,GO:0032897,GO:0034244,GO:0042802,GO:0043231,GO:0045087,GO:0045736,GO:0045736,GO:0045892,GO:0097322,GO:0097322,GO:0106140,GO:0120259,GO:1901798

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HEXIM1 PARP12 23180781 24623795 physical association anti tag coimmunoprecipitation InnateDB
HEXIM1 EPSTI1 23180781 24623795 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 HEXIM1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HEXIM1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HEXIM1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HEXIM1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 HEXIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC HEXIM1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F6E49 HEXIM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D HEXIM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 HEXIM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F HEXIM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA HEXIM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000B7E30 HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000049704B HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED HEXIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA HEXIM1 22135298 phosphorylation N/A PhosphoSite
BRD2 HEXIM1 25361965 interaction type N/A PTMCode2
HEXIM1 BRD2 25361965 interaction type N/A PTMCode2
HEXIM1 CDK9 25361965 interaction type N/A PTMCode2
CDK9 HEXIM1 25361965 interaction type N/A PTMCode2
LARP7 HEXIM1 25361965 interaction type N/A PTMCode2
HEXIM1 LARP7 25361965 interaction type N/A PTMCode2
MEPCE HEXIM1 25361965 interaction type N/A PTMCode2
HEXIM1 MEPCE 25361965 interaction type N/A PTMCode2
HEXIM1 HEXIM1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HEXIM2 HEXIM1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDX21 HEXIM1 24234451 25348397 25470060 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP1 HEXIM1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
EGLN3 HEXIM1 25348397 N/A physical interaction ComPPI
DHX9 HEXIM1 25348397 N/A physical interaction ComPPI
HIF1A HEXIM1 25348397 N/A physical interaction ComPPI
FHL2 HEXIM1 25348397 N/A physical interaction ComPPI
AP1M1 HEXIM1 25348397 N/A physical interaction ComPPI
EPHA2 HEXIM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK2A1 HEXIM1 25348397 N/A physical interaction ComPPI
NSMAF HEXIM1 25348397 N/A physical interaction ComPPI
RELA HEXIM1 12581153 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
AFF1 HEXIM1 25348397 N/A physical interaction ComPPI
CCNT2 HEXIM1 12832472 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CSNK2A2 HEXIM1 25348397 N/A physical interaction ComPPI
MDM2 HEXIM1 25348397 N/A physical interaction ComPPI
EGFR HEXIM1 20029029 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
CTTN HEXIM1 25348397 N/A physical interaction ComPPI
TCEA1 HEXIM1 20562857 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
CCNT1 HEXIM1 12832472 14525934 14580347 15169877 15201869 15940264 16109377 17724342 18281698 18483487 19387490 24234451 24367103 25348397 26186194 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,classical fluorescence spectroscopy,two hybrid,experimental interaction detection,nuclear magnetic resonance,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
SRSF11 HEXIM1 25348397 N/A physical interaction ComPPI
CDK9 HEXIM1 12832472 14525934 14580347 15169877 15201869 18483487 20562857 21533037 23455922 24234451 24360279 25348397 25470060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
DYNC1H1 HEXIM1 25348397 N/A physical interaction ComPPI
DDX1 HEXIM1 25348397 N/A physical interaction ComPPI
TERF1 HEXIM1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ESR1 HEXIM1 14525934 15940264 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BRD4 HEXIM1 25348397 N/A physical interaction ComPPI
TERF2 HEXIM1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
COPS7B HEXIM1 25348397 N/A physical interaction ComPPI
AFF4 HEXIM1 25348397 N/A physical interaction ComPPI
HEXIM1 MEPCE 25348397 N/A physical interaction ComPPI
HEXIM1 TP53 25348397 N/A physical interaction ComPPI
HEXIM1 HSPD1 25348397 N/A physical interaction ComPPI
HEXIM1 LARP7 18281698 18483487 24234451 25348397 25470060 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
HEXIM1 HDAC1 25348397 N/A physical interaction ComPPI
HEXIM1 POLA2 25348397 N/A physical interaction ComPPI
HEXIM1 SHMT2 25348397 N/A physical interaction ComPPI
HEXIM1 MOV10 25348397 N/A physical interaction ComPPI
HEXIM1 NXF1 25348397 N/A physical interaction ComPPI
HEXIM1 SURF2 25348397 N/A physical interaction ComPPI
HEXIM1 OSBPL1A 25348397 N/A physical interaction ComPPI
HEXIM1 UBE2O 25348397 N/A physical interaction ComPPI
HEXIM1 CSNK2B 25348397 N/A physical interaction ComPPI
HEXIM1 TWNK 25348397 N/A physical interaction ComPPI
HEXIM1 RTN4IP1 25348397 N/A physical interaction ComPPI
HEXIM1 NUCKS1 25348397 N/A physical interaction ComPPI
HEXIM1 NCAPH 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HEXIM1 HAUS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HEXIM1 ACTR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HEXIM1 SH3BP5L 25348397 N/A physical interaction ComPPI
HEXIM1 MACROH2A2 25348397 N/A physical interaction ComPPI
HEXIM1 CLEC14A 25348397 N/A physical interaction ComPPI
EEF1A2 HEXIM1 25348397 N/A physical interaction ComPPI
HEXIM1 HEXIM1 17724342 24234451 N/A nuclear magnetic resonance IntAct
PRKCA HEXIM1 22821562 27898060 N/A N/A OmniPath

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