Gene Information gene info

  1. Home

GENE：HSPA6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HSPA6
FullNmae heat shock protein family A (Hsp70) member 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5239
EnsembleID ENSG00000173110
Uniprot P17066

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HSPA6 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HSPA6 GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005737,GO:0005814,GO:0005829,GO:0006986,GO:0016887,GO:0016887,GO:0019899,GO:0031072,GO:0031072,GO:0031625,GO:0034605,GO:0034605,GO:0034774,GO:0042026,GO:0042026,GO:0044183,GO:0051082,GO:0051085,GO:0070062,GO:0072562,GO:0140662,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HSPA6 hsa:3310 path:hsa03040 Spliceosome - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa04144 Endocytosis - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa05020 Prion disease - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa05134 Legionellosis - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa05162 Measles - Homo sapiens (human)
HSPA6 hsa:3310 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PGLYRP1 HSPA6 17551095 23180781 physical association cross-linking study InnateDB
IL7R HSPA6 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 HSPA6 21827211 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 HSPA6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HSPA6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HSPA6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HSPA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HSPA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HSPA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HSPA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HSPA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F4AC3 HSPA6 20371350 21572407 22012620 22927820 23313552 23446348 23592263 23706177 24398324 24906430 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000001EB3 HSPA6 20371350 21572407 22012620 22927820 23313552 23446348 23592263 23706177 24398324 24906430 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075ABF4 HSPA6 20371350 21572407 22012620 22927820 23313552 23446348 23592263 23706177 24398324 24906430 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000041E780 HSPA6 20371350 21572407 22012620 22927820 23313552 23446348 23592263 23706177 24398324 24906430 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 HSPA6 23592263 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 HSPA6 23592263 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 HSPA6 23592263 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BD1DE HSPA6 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 HSPA6 23592263 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032835F HSPA6 23592263 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000243FF1 HSPA6 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 HSPA6 23592263 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000237AF9 HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D2333 HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 HSPA6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 HSPA6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF HSPA6 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 HSPA6 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIK3R2 HSPA6 25348397 N/A physical interaction ComPPI
CDC5L HSPA6 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA8 HSPA6 24234451 25348397 29568061 association pull down,physical interaction ComPPI,IntAct
PPIB HSPA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGTB HSPA6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPBP1 HSPA6 25348397 N/A physical interaction ComPPI
UBL4A HSPA6 25348397 N/A physical interaction ComPPI
MCM5 HSPA6 25348397 N/A physical interaction ComPPI
GABARAPL2 HSPA6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KEAP1 HSPA6 25348397 N/A physical interaction ComPPI
MCM2 HSPA6 25348397 N/A physical interaction ComPPI
MAP1LC3B HSPA6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CRK HSPA6 25348397 N/A physical interaction ComPPI
INSIG2 HSPA6 25348397 N/A physical interaction ComPPI
CBL HSPA6 25348397 N/A physical interaction ComPPI
REL HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SHC1 HSPA6 25348397 N/A physical interaction ComPPI
JUN HSPA6 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 HSPA6 18850735 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
COP1 HSPA6 25348397 N/A physical interaction ComPPI
INPPL1 HSPA6 25348397 N/A physical interaction ComPPI
HSP90AA1 HSPA6 25348397 N/A physical interaction ComPPI
NTRK1 HSPA6 25348397 N/A physical interaction ComPPI
ILK HSPA6 25348397 N/A physical interaction ComPPI
HSPA5 HSPA6 25348397 N/A physical interaction ComPPI
HSPA1A HSPA6 25348397 N/A physical interaction ComPPI
HSPA1B HSPA6 25348397 N/A physical interaction ComPPI
RPA1 HSPA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CISH HSPA6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TNFRSF1A HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CFTR HSPA6 25348397 N/A physical interaction ComPPI
PARD3 HSPA6 25348397 N/A physical interaction ComPPI
NEDD8 HSPA6 25348397 N/A physical interaction ComPPI
ARRB2 HSPA6 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL1 HSPA6 25348397 N/A physical interaction ComPPI
TUBA1A HSPA6 24234451 25348397 27291054 association pull down ComPPI,IntAct
GABARAP HSPA6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HDAC6 HSPA6 25348397 N/A physical interaction ComPPI
MAP1LC3A HSPA6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NOS2 HSPA6 25348397 N/A physical interaction ComPPI
PTEN HSPA6 25348397 N/A physical interaction ComPPI
STK4 HSPA6 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
RIPK2 HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BAG4 HSPA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNFRSF1B HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K14 HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NXF5 HSPA6 25348397 N/A physical interaction ComPPI
CDK9 HSPA6 25348397 N/A physical interaction ComPPI
NFKB1 HSPA6 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
AP2M1 HSPA6 25348397 N/A physical interaction ComPPI
PPP5C HSPA6 25348397 N/A physical interaction ComPPI
TERF1 HSPA6 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ESR1 HSPA6 25348397 N/A physical interaction ComPPI
DNAJB1 HSPA6 25348397 N/A physical interaction ComPPI
HNRNPD HSPA6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ESR2 HSPA6 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
RPS6KB2 HSPA6 25348397 N/A physical interaction ComPPI
STUB1 HSPA6 16293251 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
MAP3K3 HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DYRK2 HSPA6 25348397 N/A physical interaction ComPPI
TRAF3IP1 HSPA6 20391533 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SKI HSPA6 25348397 N/A physical interaction ComPPI
DNAJA1 HSPA6 25348397 N/A physical interaction ComPPI
IQCB1 HSPA6 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DNAJB6 HSPA6 25348397 N/A physical interaction ComPPI
SCFD1 HSPA6 25348397 N/A physical interaction ComPPI
MOCS3 HSPA6 25348397 N/A physical interaction ComPPI
NPHP4 HSPA6 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
STYX HSPA6 25348397 N/A physical interaction ComPPI
KNSTRN HSPA6 25348397 N/A physical interaction ComPPI
NTNG1 HSPA6 25348397 N/A physical interaction ComPPI
NEK8 HSPA6 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RELB HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CYLD HSPA6 25348397 N/A physical interaction ComPPI
TUBB3 HSPA6 24234451 25348397 27291054 association pull down ComPPI,IntAct
GABARAPL1 HSPA6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
IFT27 HSPA6 24234451 25348397 27173435 association anti tag coimmunoprecipitation ComPPI,IntAct
RPAP3 HSPA6 25348397 N/A physical interaction ComPPI
DNAJB4 HSPA6 21231916 21988832 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
LGALS7 HSPA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KIAA1191 HSPA6 25348397 N/A physical interaction ComPPI
COMMD6 HSPA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP3K1 HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DNAJA2 HSPA6 25348397 N/A physical interaction ComPPI
AHCYL1 HSPA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TP53 HSPA6 25348397 N/A physical interaction ComPPI
MLF2 HSPA6 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAB1 HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSP90AA2P HSPA6 25348397 N/A physical interaction ComPPI
GAN HSPA6 25348397 N/A physical interaction ComPPI
IKBKG HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
OTUB1 HSPA6 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F3 HSPA6 22157815 24234451 25348397 association pull down ComPPI,IntAct
RIPK4 HSPA6 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MEPCE HSPA6 25348397 N/A physical interaction ComPPI
HSPA6 HSPA1L 25348397 N/A physical interaction ComPPI
HSPA6 CYP4F12 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSPA6 DNAJA4 25348397 N/A physical interaction ComPPI
HSPA6 DNAJB5 25348397 N/A physical interaction ComPPI
HSPA6 DNAJB7 25348397 N/A physical interaction ComPPI
HSPA6 DNAJB8 25348397 N/A physical interaction ComPPI
HSPA6 CCNI2 25348397 N/A physical interaction ComPPI
HSPA6 LRRC28 25348397 N/A physical interaction ComPPI
HSPA6 POC1A 25348397 N/A physical interaction ComPPI
HSPA6 VASH1 25348397 N/A physical interaction ComPPI
HSPA6 RC3H1 25348397 N/A physical interaction ComPPI
HSPA6 PRODH 25348397 N/A physical interaction ComPPI
HSPA6 TTC30B 25348397 N/A physical interaction ComPPI
HSPA6 KLHL34 25348397 N/A physical interaction ComPPI
HSPA6 ABHD15 25348397 N/A physical interaction ComPPI
HSPA6 VILL 25348397 N/A physical interaction ComPPI
HSPA6 PRAP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPA6 KRT222 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSSK1B HSPA6 25348397 N/A physical interaction ComPPI
ADCK5 HSPA6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSPA6 SNIP1 24234451 30021884 physical association cross-linking study IntAct
TPT1 HSPA6 24234451 27607350 association anti bait coimmunoprecipitation IntAct
IL7R HSPA6 20167604 27898060 N/A N/A OmniPath
PGLYRP1 HSPA6 17551095 27898060 N/A N/A OmniPath

Visualization










  Return