GENE：MCM8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MCM8 |
| FullNmae | minichromosome maintenance 8 homologous recombination repair factor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16147 |
| EnsembleID | ENSG00000125885 |
| Uniprot | Q9UJA3 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MCM8 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MCM8 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MCM8 | GO:0000724,GO:0000724,GO:0000724,GO:0003682,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005694,GO:0006974,GO:0007049,GO:0007292,GO:0016887,GO:0017116,GO:0019899,GO:0032406,GO:0032407,GO:0032408,GO:0032508,GO:0036298,GO:0042555,GO:0048232,GO:0050821,GO:0070716,GO:0071168,GO:0097362,GO:0097362 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MCM8 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | MCM8 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| MYCN | MCM8 | 17826980 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | MCM8 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | MCM8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MCM8 | 16325355 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000338542 | MCM8 | 20584899 | rna interference,inhibition | experimental interaction detection | miRSponge |
| URS00000AA464 | MCM8 | 20304954 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000338542 | MCM8 | 20584899 22473208 25416803 | mrna cleavage,inhibition | experimental interaction detection,clip | TarBase |
| URS0000157026 | MCM8 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000285DCB | MCM8 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | MCM8 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | MCM8 | 23313552 23824327 24906430 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AF45F | MCM8 | 24906430 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000006A1CB | MCM8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171020 | MCM8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000136174 | MCM8 | 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EC1BE | MCM8 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001481F9 | MCM8 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | MCM8 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000008A99 | MCM8 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000221168 | MCM8 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | MCM8 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | MCM8 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | MCM8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AF715 | MCM8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C1E1 | MCM8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032835F | MCM8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | MCM8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006BE7D | MCM8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000521626 | MCM8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | MCM8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003380CC | MCM8 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | MCM8 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000043C1C3 | MCM8 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E92A8 | MCM8 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BCD9C | MCM8 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AFAD1 | MCM8 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A4ABF | MCM8 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TUBB | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| MCM6 | MCM8 | 12771218 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| SKAP1 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| CDC6 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| F9 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| ORC2 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| SKP2 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| RAD50 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| MCM4 | MCM8 | 12771218 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MLH1 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| IL17RA | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
| MCM7 | MCM8 | 12771218 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MCM8 | MCMBP | 22540012 24234451 24299456 25036637 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MCM8 | KLK5 | 25348397 | N/A | physical interaction | ComPPI |
| MCM8 | AVIL | 25348397 | N/A | physical interaction | ComPPI |
| MCM8 | MSH2 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA5 | MCM8 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| MYCN | MCM8 | 17826980 27898060 | stimulant | N/A | OmniPath |