GENE：MEIS2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MEIS2 |
| FullNmae | Meis homeobox 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7001 |
| EnsembleID | ENSG00000134138 |
| Uniprot | O14770 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MEIS2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MEIS2 | GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0001228,GO:0001228,GO:0001228,GO:0001654,GO:0003677,GO:0005515,GO:0005634,GO:0007420,GO:0008134,GO:0008284,GO:0008542,GO:0009612,GO:0009880,GO:0009887,GO:0031016,GO:0045638,GO:0045931,GO:0045944,GO:0045944,GO:0048471,GO:0070848,GO:0110024,GO:1990837 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MEIS2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MEIS2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MEIS2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MEIS2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | MEIS2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | MEIS2 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | MEIS2 | 12747840 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | MEIS2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | MEIS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000029D9F1 | MEIS2 | 20713703 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS000029D9F1 | MEIS2 | 20713703 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00000F31F4 | MEIS2 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | MEIS2 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RBPMS | MEIS2 | 25348397 | N/A | barcode fusion genetics two hybrid | ComPPI |
| MAB21L2 | MEIS2 | 25348397 | N/A | physical interaction | ComPPI |
| OIP5 | MEIS2 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | ANXA1 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| MEIS2 | HOXA13 | 14525934 15617687 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| MEIS2 | HOXA9 | 14525934 15161102 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MEIS2 | PBX1 | 11279116 20211142 25348397 26186194 27898060 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI,OmniPath |
| MEIS2 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | ZNHIT3 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | SP1 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | APP | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | SOX2 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | SQSTM1 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | ARNT2 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | DGCR6 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | CRBN | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | OSGIN1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| MEIS2 | C1ORF94 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| MEIS2 | LMX1B | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | MAB21L1 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | MEIS3 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | MEIS1 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | PBX2 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | PBX4 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| MEIS2 | PBX3 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | GNB4 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | PIGL | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | FAM222A | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | CCDC120 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | DNAAF8 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | TMOD3 | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | ACTB | 25348397 | N/A | physical interaction | ComPPI |
| MEIS2 | UBB | 25348397 | N/A | physical interaction,comigration in sds page | ComPPI |
| MEIS2 | UBC | 25348397 | N/A | physical interaction,comigration in sds page | ComPPI |
| MEIS2 | RPS27A | 25348397 | N/A | physical interaction,comigration in sds page | ComPPI |
| MEIS2 | UBA52 | 25348397 | N/A | physical interaction,comigration in sds page | ComPPI |
| MEIS2 | IGFBP6 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | ITGB3BP | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | TIMM10B | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | BPIFA1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | FAM136A | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | CARTPT | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | POU2AF1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | NUP58 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | GUSBP1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | TBX2 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | TRIM42 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | CTAG1A | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | KRTAP11-1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | PTK6 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | KRTAP10-8 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | MCCD1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | SERHL | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | ADRA2C | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | SMRP1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | NDUFB7 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | VGLL1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | KRTAP19-2 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | KRTAP6-2 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | SCT | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | POU6F2 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | KRTAP19-6 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | NOTO | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | ANTKMT | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | KRTAP6-1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | RUSC1 | 25348397 | N/A | two hybrid | ComPPI |
| MEIS2 | MEIS2 | 24234451 25416956 | physical association | two hybrid array | IntAct |
| MEIS2 | PAX6 | 12183364 27898060 | stimulant | N/A | OmniPath |