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GENE：NEK11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NEK11
FullNmae NIMA related kinase 11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18593
EnsembleID ENSG00000114670
Uniprot Q8NG66

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NEK11 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NEK11 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NEK11 GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0006468,GO:0031573,GO:0031573,GO:0035556,GO:0046872,GO:0106310,GO:1901990,GO:1901990

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR NEK11 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F6 NEK11 12909625 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 NEK11 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NEK11 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A NEK11 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 NEK11 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CHEK1 NEK11 22135298 phosphorylation N/A PhosphoSite
NEK11 CDC25A 22135298 phosphorylation N/A PhosphoSite
NEK11 BLM 22135298 phosphorylation N/A PhosphoSite
NEK2 NEK11 25361965 interaction type N/A PTMCode2
NEK11 NEK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSP90AB1 NEK11 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSP90AA1 NEK11 25348397 N/A physical interaction ComPPI
MYC NEK11 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NEK2 NEK11 14525934 15161910 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,fluorescence microscopy,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
BLM NEK11 25348397 N/A physical interaction ComPPI
NEK11 APP 25348397 N/A physical interaction ComPPI
NEK11 HSP90AA2P 25348397 N/A physical interaction ComPPI
NEK11 HERC2 25348397 N/A physical interaction ComPPI
NEK11 HERC2P3 25348397 N/A physical interaction ComPPI
NEK11 FKBP5 25348397 N/A physical interaction ComPPI
NEK11 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
NEK11 NEK11 14525934 15161910 24234451 phosphorylation reaction anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
HMGN2 NEK11 24234451 30021884 physical association cross-linking study IntAct
NEK11 CDC25A 14603323 14681206 14752276 15021892 15798217 19734889 20090422 21252624 27898060 inhibition N/A OmniPath
CHEK1 NEK11 19734889 20090422 27898060 stimulant N/A OmniPath
NEK11 BLM 24239288 25794620 27898060 N/A N/A OmniPath
NEK2 NEK11 15161910 27898060 stimulant N/A OmniPath

Visualization










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