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GENE：TOPORS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TOPORS
FullNmae TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21653
EnsembleID ENSG00000197579
Uniprot Q9NS56

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TOPORS parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOPORS autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOPORS apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOPORS apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TOPORS GO:0000151,GO:0000209,GO:0000209,GO:0000922,GO:0000930,GO:0003677,GO:0003823,GO:0004842,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005814,GO:0006351,GO:0006511,GO:0006513,GO:0006513,GO:0006974,GO:0008630,GO:0016605,GO:0016607,GO:0016607,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0019789,GO:0019789,GO:0019789,GO:0030496,GO:0032391,GO:0032391,GO:0034504,GO:0036064,GO:0036064,GO:0042127,GO:0042771,GO:0043161,GO:0044547,GO:0045893,GO:0046872,GO:0051443,GO:0051457,GO:0061630,GO:0061630,GO:0070936

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 TOPORS 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TOPORS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TOPORS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 TOPORS 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TOPORS 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TOPORS 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TOPORS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TOPORS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TOPORS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TOPORS N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D TOPORS 18829576 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D TOPORS 18591254 18829576 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000042E1F TOPORS 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TOPORS 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TOPORS 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TOPORS 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TOPORS 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA TOPORS 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PLK1 TOPORS 22135298 phosphorylation N/A PhosphoSite
TP53 TOPORS 25361965 interaction type N/A PTMCode2
TOPORS TP53 25361965 interaction type N/A PTMCode2
TOPORS TOP1 25361965 interaction type N/A PTMCode2
TOP1 TOPORS 25361965 interaction type N/A PTMCode2
TOPORS SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 TOPORS 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I TOPORS 14516784 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
DHX15 TOPORS 25348397 N/A physical interaction ComPPI
TP53BP1 TOPORS 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
UBE2D1 TOPORS 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SNIP1 TOPORS 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
NIFK TOPORS 25348397 N/A physical interaction ComPPI
UBE2E3 TOPORS 25348397 N/A physical interaction ComPPI
UBE2D4 TOPORS 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SUMO1 TOPORS 11842245 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SF3B1 TOPORS 25348397 N/A physical interaction ComPPI
NONO TOPORS 25348397 N/A physical interaction ComPPI
SFPQ TOPORS 25348397 N/A physical interaction ComPPI
UBE2D2 TOPORS 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GTF2I TOPORS 25348397 N/A physical interaction ComPPI
UBC TOPORS 25348397 N/A physical interaction ComPPI
UBE2N TOPORS 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PARP1 TOPORS 25348397 N/A physical interaction ComPPI
SIN3A TOPORS 25348397 N/A physical interaction ComPPI
PLK1 TOPORS 25348397 N/A physical interaction ComPPI
CASP8 TOPORS 14525934 17290218 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
EEF1A1 TOPORS 25348397 N/A physical interaction ComPPI
HNRNPL TOPORS 25348397 N/A physical interaction ComPPI
HABP4 TOPORS 14525934 16455055 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RBBP4 TOPORS 25348397 N/A physical interaction ComPPI
TOPORS TOP1 10352183 14525934 17976381 20805487 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TOPORS TP53 10415337 14525934 17290218 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
TOPORS UBE2D3 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TOPORS UBE2J1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TOPORS UBE2L6 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TOPORS UBE2W 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TOPORS SAFB2 25348397 N/A physical interaction ComPPI
TOPORS DDB2 25348397 N/A physical interaction ComPPI
TOPORS RBBP7 25348397 N/A physical interaction ComPPI
TOPORS TRIM28 25348397 N/A physical interaction ComPPI
TOPORS SMARCC2 25348397 N/A physical interaction ComPPI
TOPORS RANGAP1 25348397 N/A physical interaction ComPPI
TOPORS UPF3A 25348397 N/A physical interaction ComPPI
TOPORS HNRNPM 25348397 N/A physical interaction ComPPI
TOPORS HNRNPA1 25348397 N/A physical interaction ComPPI
TOPORS EEF1A1P5 25348397 N/A physical interaction ComPPI
TOPORS S100A9 25348397 N/A physical interaction ComPPI
TOPORS SATB1 18408014 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TOPORS NKX3-1 25348397 N/A physical interaction ComPPI
TOPORS UBXN7 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOPORS IKBKE 25348397 N/A physical interaction ComPPI
TOPORS PML 25348397 N/A physical interaction ComPPI
TOPORS SERBP1 25348397 N/A physical interaction ComPPI
TOPORS H2AX 25348397 N/A physical interaction ComPPI
TOPORS UBE2E1 25348397 N/A physical interaction ComPPI
TOPORS SUMO2 25348397 N/A physical interaction ComPPI
TOPORS MTDH 24529480 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TOPORS SPIN2B 25348397 N/A physical interaction ComPPI
TOPORS SPIN1 25348397 N/A physical interaction ComPPI
TOPORS EPM2A 25348397 N/A physical interaction ComPPI
TOPORS PSMC1 25348397 26872363 27898060 N/A physical interaction ComPPI,OmniPath
TOPORS LLGL2 25348397 N/A physical interaction ComPPI
TOPORS ZC3H18 25348397 N/A physical interaction ComPPI
TOPORS ZNF786 25348397 N/A physical interaction ComPPI
TOPORS ZNF214 25348397 N/A physical interaction ComPPI
TOPORS ZNF324B 25348397 N/A physical interaction ComPPI
TOPORS ZNF816 25348397 N/A physical interaction ComPPI
TOPORS NKAP 25348397 N/A physical interaction ComPPI
TOPORS PNN 25348397 N/A physical interaction ComPPI
TOPORS CLK3 25348397 N/A physical interaction ComPPI
TOPORS SETX 24234451 24244371 25348397 physical association two hybrid ComPPI,IntAct
ZNF263 TOPORS 25348397 N/A physical interaction ComPPI
MAM TOPORS 15710747 24234451 25348397 physical association physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
TOPORS TOPORS 11842245 14525934 N/A experimental interaction detection,two hybrid HPRD
SDC1 TOPORS 22912899 27898060 N/A N/A OmniPath
PLK1 TOPORS 19053840 19473992 19821153 22972498 27898060 inhibition,stimulant N/A OmniPath
TOPORS TP53 10415337 11842245 15247280 16122737 17290218 17803295 19473992 27898060 inhibition,stimulant N/A OmniPath

Visualization










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