Gene Information gene info

  1. Home

GENE：CBLB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CBLB
FullNmae Cbl proto-oncogene B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1542
EnsembleID ENSG00000114423
Uniprot Q13191

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CBLB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CBLB autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CBLB GO:0001784,GO:0002669,GO:0002870,GO:0005509,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006607,GO:0006955,GO:0007165,GO:0007175,GO:0008270,GO:0016567,GO:0017124,GO:0030163,GO:0030971,GO:0031398,GO:0035556,GO:0035739,GO:0045121,GO:0045732,GO:0050852,GO:0050860,GO:0061630,GO:2000562,GO:2000583

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CBLB hsa:868 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
CBLB hsa:868 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
CBLB hsa:868 path:hsa04144 Endocytosis - Homo sapiens (human)
CBLB hsa:868 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
CBLB hsa:868 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CBLB hsa:868 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
CBLB hsa:868 path:hsa05162 Measles - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CBLB VAV1 10426994 10646608 11526404 11907067 15536084 16713974 19592273 26192618 interaction type N/A ACSN
PIK3R1 CBLB 11087752 11526404 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,ubiquitination reaction InnateDB
CBLB CD33 18062779 23180781 physical association pull down InnateDB
CBLB UBC 19285159 23180781 physical association protein array InnateDB
CBLB CBLB 11375397 16503409 26467481 8626404 ubiquitination reaction,bind,up-regulates activity,down-regulates activity N/A Signor
ZAP70 CBLB 10074432 23109003 8798643 chemical activation reaction N/A SignaLink
CBLB PIK3R1 10488096 11526404 15032589 21780115 22880054 23109003 inhibition N/A SignaLink
CTLA4 CBLB 16860761 23109003 chemical activation reaction N/A SignaLink
CD28 CBLB 12193687 23109003 inhibition N/A SignaLink
CBLB PTEN 22763434 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BLNK CBLB 20005715 interaction type N/A PSP
CD2AP CBLB 20005715 interaction type N/A PSP
FYB1 CBLB 20005715 interaction type N/A PSP
GRB2 CBLB 20005715 interaction type N/A PSP
NCK1 CBLB 20005715 interaction type N/A PSP,SignaLink
NCK2 CBLB 20005715 interaction type N/A PSP
PIK3R1 CBLB 10022120 20005715 21071413 9614102 interaction type N/A PSP,SignaLink
SHC1 CBLB 20005715 interaction type N/A PSP
SORBS3 CBLB 20005715 interaction type N/A PSP
SPRY2 CBLB 20005715 interaction type N/A PSP
CBLB EGFR 10086340 10086340 16702950 16729043 18316398 18988627 19531499 20542890 21071413 stimulation N/A SignaLink
NCK2 CBLB 16189514 20005715 21071413 N/A N/A SignaLink
SHC1 CBLB 20005715 21071413 9614102 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR CBLB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 CBLB 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 CBLB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CBLB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CBLB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 CBLB 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CBLB 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CBLB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CBLB 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CBLB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000235862 CBLB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 CBLB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC CBLB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6479 CBLB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000016C318 CBLB 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCQ CBLB 22135298 phosphorylation N/A PhosphoSite
CBLB ZAP70 25361965 interaction type N/A PTMCode2
ZAP70 CBLB 25361965 interaction type N/A PTMCode2
CBLB PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R1 CBLB 25361965 interaction type N/A PTMCode2
CBLB EGFR 25361965 interaction type N/A PTMCode2
EGFR CBLB 25361965 interaction type N/A PTMCode2
CBLB KIT 25361965 interaction type N/A PTMCode2
KIT CBLB 25361965 interaction type N/A PTMCode2
CBLB CRK 25361965 interaction type N/A PTMCode2
CRK CBLB 25361965 interaction type N/A PTMCode2
CBLB YES1 25361965 interaction type N/A PTMCode2
YES1 CBLB 25361965 interaction type N/A PTMCode2
CBLB GRB2 25361965 interaction type N/A PTMCode2
GRB2 CBLB 25361965 interaction type N/A PTMCode2
CBLB ERBB4 25361965 interaction type N/A PTMCode2
ERBB4 CBLB 25361965 interaction type N/A PTMCode2
CBLB SPRY1 25361965 interaction type N/A PTMCode2
SPRY1 CBLB 25361965 interaction type N/A PTMCode2
CBLB NEDD4 25361965 interaction type N/A PTMCode2
NEDD4 CBLB 25361965 interaction type N/A PTMCode2
CBLB CRKL 25361965 interaction type N/A PTMCode2
CRKL CBLB 25361965 interaction type N/A PTMCode2
CBLB RET 25361965 interaction type N/A PTMCode2
RET CBLB 25361965 interaction type N/A PTMCode2
CBLB CD2AP 25361965 interaction type N/A PTMCode2
CD2AP CBLB 25361965 interaction type N/A PTMCode2
CBLB FYN 25361965 interaction type N/A PTMCode2
FYN CBLB 25361965 interaction type N/A PTMCode2
CBLB ARHGEF7 25361965 interaction type N/A PTMCode2
ARHGEF7 CBLB 25361965 interaction type N/A PTMCode2
CBLB SYK 25361965 interaction type N/A PTMCode2
SYK CBLB 25361965 interaction type N/A PTMCode2
CBLB CARD11 25361965 interaction type N/A PTMCode2
CARD11 CBLB 25361965 interaction type N/A PTMCode2
CBLB SH3KBP1 25361965 interaction type N/A PTMCode2
SH3KBP1 CBLB 25361965 interaction type N/A PTMCode2
CBLB JAK3 25361965 interaction type N/A PTMCode2
JAK3 CBLB 25361965 interaction type N/A PTMCode2
LCP2 CBLB 25361965 interaction type N/A PTMCode2
CBLB LCP2 25361965 interaction type N/A PTMCode2
PIK3R2 CBLB 25361965 interaction type N/A PTMCode2
CBLB PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 CBLB 14525934 16189514 24234451 25348397 25416956 26871637 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
HNRNPK CBLB 25348397 N/A physical interaction ComPPI
PIK3R2 CBLB 25348397 N/A physical interaction ComPPI
YES1 CBLB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRY2 CBLB 11053437 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SPRY1 CBLB 25348397 N/A physical interaction ComPPI
UBASH3A CBLB 25348397 N/A two hybrid ComPPI
UBASH3B CBLB 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SH3KBP1 CBLB 12177062 12218189 12829691 14525934 18680311 19268472 23663663 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,isothermal titration calorimetry,nuclear magnetic resonance,x-ray crystallography,physical interaction,two hybrid array,competition binding,enzyme linked immunosorbent assay,in vivo,x ray scattering,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
SORBS3 CBLB 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GLRX3 CBLB 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
WAS CBLB 25348397 N/A physical interaction ComPPI
TRAF6 CBLB 25348397 N/A physical interaction ComPPI
CRK CBLB 19380743 24234451 25348397 25814554 association,physical association physical interaction,two hybrid array,tandem affinity purification,validated two hybrid ComPPI,IntAct
APPL1 CBLB 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
CBL CBLB 25348397 N/A physical interaction ComPPI
VAV1 CBLB 11857085 14525934 25348397 27898060 9399639 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
BTK CBLB 25348397 N/A physical interaction ComPPI
SYK CBLB 10022120 12771181 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTK2B CBLB 25348397 N/A physical interaction ComPPI
CBLB ZAP70 10074432 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CBLB GRB2 10086340 12577067 14525934 20936779 21706016 21900206 24234451 25348397 25416956 27107012 29997244 association,physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,luminescence based mammalian interactome mapping,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CBLB PLCG2 25348397 N/A physical interaction,in vitro ComPPI
CBLB SHC1 14525934 25348397 9614102 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CBLB CRKL 10022120 14525934 24234451 25348397 25814554 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,validated two hybrid ComPPI,HPRD,IntAct
CBLB NEDD4 12907674 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CBLB BLNK 12093870 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CBLB PIK3R1 10086340 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CBLB GORASP2 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CBLB CRY1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CBLB RET 14525934 16525057 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CBLB NCK1 14525934 16503409 24234451 25218436 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CBLB FYB1 14525934 16503409 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CBLB FYN 14525934 16503409 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CBLB KIT 14525934 15315962 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CBLB TNFRSF11A 11406619 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CBLB ARHGEF7 12935897 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
CBLB EGFR 10086340 14525934 15657067 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CBLB FLT3 14525934 25348397 9614102 N/A experimental interaction detection,in vivo ComPPI,HPRD
CBLB RNF11 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CBLB IRS1 25348397 N/A physical interaction ComPPI
CBLB UBC 25348397 N/A pull down,physical interaction,physical interaction,comigration in sds page ComPPI
CBLB CARD11 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
CBLB ASAP1 17255943 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CBLB CD2AP 17020880 23663663 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,isothermal titration calorimetry,nuclear magnetic resonance,pull down,x-ray crystallography,physical interaction ComPPI,IntAct
CBLB ITSN1 25348397 N/A physical interaction ComPPI
CBLB MS4A2 25348397 N/A physical interaction ComPPI
CBLB MYD88 17618294 20639876 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CBLB TICAM1 25348397 N/A physical interaction ComPPI
CBLB PTPN11 25348397 N/A physical interaction ComPPI
CBLB TANK 25348397 N/A physical interaction ComPPI
CBLB TRAF3 25348397 N/A physical interaction ComPPI
CBLB LCK 25348397 N/A physical interaction ComPPI
CBLB ABL1 25348397 N/A physical interaction ComPPI
CBLB UBE2D2 22158902 25348397 27898060 N/A fluorescence polarization spectroscopy,nuclear magnetic resonance,physical interaction ComPPI,OmniPath
CBLB VAV2 25348397 N/A physical interaction ComPPI
CBLB TGFB1I1 25348397 N/A physical interaction ComPPI
CBLB DDR2 24234451 24631539 25348397 26826182 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
CBLB SIRT2 25348397 N/A physical interaction ComPPI
CBLB NTRK1 25348397 N/A physical interaction ComPPI
CBLB GRAP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLB IPO8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CBLB SP7 25348397 N/A physical interaction ComPPI
CBLB USP12 25348397 N/A physical interaction ComPPI
CBLB PDGFRB 25348397 N/A physical interaction ComPPI
CBLB TNFRSF10B 25348397 N/A physical interaction ComPPI
CBLB TRAF2 25348397 N/A physical interaction ComPPI
CBLB NR2C2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
CBLB UBA52 25348397 N/A pull down,physical interaction,comigration in sds page ComPPI
CBLB ASAP2 17255943 24234451 25348397 physical association pull down ComPPI,IntAct
CBLB SRC 17094785 24234451 25348397 physical association competition binding ComPPI,IntAct
CBLB ABI1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
CBLB LRRK1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CBLB UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
CBLB UBA1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
CBLB UBE2N 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
CBLB PRMT2 24234451 25348397 26871637 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CBLB PTK6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBLB VAV3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBLB VPS26C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBLB PDPK1 24234451 25348397 26593251 association coimmunoprecipitation ComPPI,IntAct
CBLB ULK1 24234451 25348397 26593251 association coimmunoprecipitation ComPPI,IntAct
CBLB LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
CBLB DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
CBLB MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
UBB CBLB 25348397 N/A pull down,physical interaction,comigration in sds page ComPPI
RPS27A CBLB 25348397 N/A pull down,physical interaction,comigration in sds page ComPPI
CFLAR CBLB 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
HMGB2 CBLB 24234451 30021884 physical association cross-linking study IntAct
SMAD7 CBLB 23709694 27898060 N/A N/A OmniPath
CBLB UBC 14661060 16007098 18596201 19285159 19880507 27898060 N/A N/A OmniPath
CBLB SRC 11448952 17094785 27898060 inhibition N/A OmniPath
CBLB LCK 11904433 27898060 8083187 inhibition N/A OmniPath
CBLB FYN 15208330 16503409 27898060 8083187 inhibition N/A OmniPath
CBLB EGFR 10086340 10542134 10635327 11375397 16702950 16729043 18271526 19531499 24797263 27898060 inhibition,stimulant N/A OmniPath
CBLB NCK1 16503409 25218436 27898060 stimulant N/A OmniPath
PRKCQ CBLB 19549985 27898060 N/A N/A OmniPath
CBLB GRB2 10022120 10086340 11375397 12577067 20936779 21706016 21900206 25416956 27898060 8626404 9614102 inhibition,stimulant N/A OmniPath
CBLB PIK3CA 11087752 27898060 inhibition N/A OmniPath
CBLB SHC1 11375397 27898060 9614102 inhibition N/A OmniPath
PIK3R1 CBLB 10022120 10086340 11087752 11526404 19190244 27898060 9614102 N/A N/A OmniPath
CBLB PIK3R1 10022120 10086340 11087752 11526404 19190244 27898060 9614102 stimulant N/A OmniPath
CBLB CRK 12697763 19380743 25814554 27898060 8626404 inhibition N/A OmniPath
CBLB VAV2 12881521 27898060 inhibition N/A OmniPath
CD33 CBLB 18062779 27898060 N/A N/A OmniPath
SPRY2 CBLB 11053437 27898060 inhibition N/A OmniPath

Visualization










  Return